Vitamin D für Autoimmune Conditions
A Evidenz Mehrere große klinische Studien zeigen übereinstimmend signifikante Vorteile.The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Fazit
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Population: patients with rheumatoid arthritis
Population: Patients with rheumatoid arthritis
Population: None
Population: Systematic review of nutraceuticals in rheumatoid arthritis
Population: SLE patients (EULAR/ACR 2019 criteria)
Population: None
Key Statistics
3
Studien
25871
Teilnehmer
Positive
Bewertung
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Übliche Dosierungen
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Obergrenze: 4,000 IU/day (100 mcg)
In der Forschung untersuchte Dosierungen
| Dosierung | Dauer | Wirkung | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
Beste Einnahmezeit: With a meal containing fat for better absorption
Safety & Side Effects
Gemeldete Nebenwirkungen
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Bekannte Wechselwirkungen
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Tolerierbare Höchstaufnahmemenge: 4,000 IU/day (100 mcg)
Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
How much Vitamin D should I take for Autoimmune Conditions?
Are there side effects of Vitamin D?
How strong is the evidence for Vitamin D and Autoimmune Conditions?
Related Evidence
Andere Inhaltsstoffe für Autoimmune Conditions
Vitamin D für andere Beschwerden
References
- [1] Elena Deseatnicova et al.. Nutrients. 2026. Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity. doi:10.3390/nu18030517 PubMed
- [2] Sarah Khan et al.. Nat Rev Endocrinol. 2025. Hypoparathyroidism: diagnosis, management and emerging therapies. doi:10.1038/s41574-024-01075-8 PubMed
- [3] Camila Leiva-Castro et al.. Inflammopharmacology. 2025. Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions. doi:10.1007/s10787-025-01976-8 PubMed
- [4] Maria Polyzou et al.. Nutrients. 2025. The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review. doi:10.3390/nu17243826 PubMed
- [5] Oana Raluca Predescu et al.. Cureus. 2025. Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus. doi:10.7759/cureus.78830 PubMed
- [6] Karen H Costenbader et al.. Arthritis Rheumatol. 2024. Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled … doi:10.1002/art.42811 PubMed
- [7] Bhavani Sowndharya Balamurugan et al.. Immun Ageing. 2024. Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity. doi:10.1186/s12979-024-00492-7 PubMed
- [8] Atia Rasheed et al.. Front Immunol. 2024. Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. doi:10.3389/fimmu.2024.1503808 PubMed
- [9] Gunnar Houen. Autoimmun Rev. 2024. Auto-immuno-deficiency syndromes. doi:10.1016/j.autrev.2024.103610 PubMed
- [10] Ling-Jun Ho et al.. Biochem Pharmacol. 2024. Vitamin D and systemic lupus erythematosus: Causality and association with disease activity and therapeutics. doi:10.1016/j.bcp.2024.116417 PubMed
- [11] Siddhi B Chikhalkar et al.. Indian Dermatol Online J. 2024. Efficacy and Safety of Topical Tofacitinib for the Treatment of Alopecia Areata. doi:10.4103/idoj.idoj_535_23 PubMed
- [12] Savino Sciascia et al.. Nutrients. 2024. The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study. doi:10.3390/nu16234132 PubMed
- [13] Lambros Athanassiou et al.. Biomolecules. 2023. Vitamin D and Autoimmune Rheumatic Diseases. doi:10.3390/biom13040709 PubMed
- [14] Elena Nikiphorou et al.. Autoimmun Rev. 2023. Nutrition and its role in prevention and management of rheumatoid arthritis. doi:10.1016/j.autrev.2023.103333 PubMed
- [15] Ioanna Aggeletopoulou et al.. Am J Pathol. 2023. Vitamin D and Microbiome: Molecular Interaction in Inflammatory Bowel Disease Pathogenesis. doi:10.1016/j.ajpath.2023.02.004 PubMed
- [16] Hanane Touil et al.. Front Immunol. 2023. Differential impact of environmental factors on systemic and localized autoimmunity. doi:10.3389/fimmu.2023.1147447 PubMed
- [17] Filip Lebiedziński et al.. Nutrients. 2023. Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice. doi:10.3390/nu15143174 PubMed
- [18] Sizheng Steven Zhao et al.. Semin Arthritis Rheum. 2023. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. doi:10.1016/j.semarthrit.2023.152238 PubMed
- [19] Yilan Zeng et al.. Mini Rev Med Chem. 2023. The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases. doi:10.2174/1389557523666221124123206 PubMed
- [20] Fatemeh Mokhtari et al.. J Cosmet Dermatol. 2023. Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study. doi:10.1111/jocd.15994 PubMed
- [21] Manisha Singh Basukala et al.. J Nepal Health Res Counc. 2023. Determination of Serum 25-Hydroxyvitamin D Levels in Patients with Alopecia Areata. doi:10.33314/jnhrc.v20i3.4408 PubMed
- [22] Jill Hahn et al.. BMJ. 2022. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. doi:10.1136/bmj-2021-066452 PubMed
- [23] Aniceta A Mikulska et al.. Int J Mol Sci. 2022. Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. doi:10.3390/ijms23126580 PubMed
- [24] Jane Fletcher et al.. Endocr Connect. 2022. Autoimmune disease and interconnections with vitamin D. doi:10.1530/EC-21-0554 PubMed
- [25] Yanbin Dong et al.. Nutrients. 2022. Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL … doi:10.3390/nu14245307 PubMed
- [26] Irina V Belyaeva et al.. Pathophysiology. 2022. Tuberculosis and Autoimmunity. doi:10.3390/pathophysiology29020022 PubMed
- [27] Valeria Dipasquale et al.. Front Biosci (Landmark Ed). 2022. Vitamin D in Prevention of Autoimmune Diseases. doi:10.31083/j.fbl2710288 PubMed
- [28] Yamei Gao et al.. J Cosmet Dermatol. 2022. Evaluation of several immune and inflammatory indicators and their association with alopecia areata. doi:10.1111/jocd.14504 PubMed
- [29] Karen H Costenbader. BMJ. 2022. Vitamin D and fish oil supplements and risk of autoimmune disease. doi:10.1136/bmj.o243 PubMed
- [30] E Lubberts. Ned Tijdschr Geneeskd. 2022. [Vitamin D like one of few prevention possibilities for autoimmune diseases?]. PubMed
- [31] Krishna C Thandra et al.. Med Sci (Basel). 2021. Epidemiology of Non-Hodgkin's Lymphoma. doi:10.3390/medsci9010005 PubMed
- [32] Giovanna Borriello et al.. Int J Environ Res Public Health. 2021. Alopecia Universalis Occurring after Alemtuzumab Treatment for Multiple Sclerosis. A Two-Year Follow-Up of Two Patients. doi:10.3390/ijerph18147338 PubMed
- [33] Felix Paolo J Lizarondo et al.. JAAD Int. 2021. Determination of serum 25-hydroxyvitamin D levels in patients with alopecia areata and their comparison with levels in healthy controls: A … doi:10.1016/j.jdin.2021.07.008 PubMed
- [34] Chiara Gioia et al.. Nutrients. 2020. Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations? doi:10.3390/nu12051456 PubMed
- [35] Stephanie R Harrison et al.. Calcif Tissue Int. 2020. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. doi:10.1007/s00223-019-00577-2 PubMed
- [36] Inês Henriques Vieira et al.. Nutrients. 2020. Vitamin D and Autoimmune Thyroid Disease-Cause, Consequence, or a Vicious Cycle? doi:10.3390/nu12092791 PubMed
- [37] Stefan Tukaj. Acta Biochim Pol. 2020. Vitamin D in autoimmune bullous disease. doi:10.18388/abp.2020_2905 PubMed
- [38] Vera Sau-Fong Chan. Adv Exp Med Biol. 2020. Epigenetics in Multiple Sclerosis. doi:10.1007/978-981-15-3449-2_12 PubMed
- [39] Andrea Fava et al.. J Autoimmun. 2019. Systemic lupus erythematosus: Diagnosis and clinical management. doi:10.1016/j.jaut.2018.11.001 PubMed
- [40] Michal A Zmijewski. Int J Mol Sci. 2019. Vitamin D and Human Health. doi:10.3390/ijms20010145 PubMed
- [41] Xia Jiang et al.. Bone. 2019. The genetics of vitamin D. doi:10.1016/j.bone.2018.10.006 PubMed
- [42] Hans-Klaus Goischke. Ther Clin Risk Manag. 2019. Vitamin D supplementation for the prevention or depletion of side effects of therapy with alemtuzumab in multiple sclerosis. doi:10.2147/TCRM.S188941 PubMed
- [43] Seyed-Amir Tabatabaeizadeh et al.. J Res Med Sci. 2018. Vitamin D, the gut microbiome and inflammatory bowel disease. doi:10.4103/jrms.JRMS_606_17 PubMed
- [44] Katarzyna Kolarz et al.. Wiad Lek. 2018. [Early reumatoid arthritis]. PubMed
- [45] Shiqian Hu et al.. Thyroid. 2017. Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis. doi:10.1089/thy.2016.0635 PubMed
- [46] Giorgia Bizzaro et al.. Isr Med Assoc J. 2017. Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? PubMed
- [47] William J Griffiths et al.. Anal Biochem. 2017. Cholesterolomics: An update. doi:10.1016/j.ab.2017.01.009 PubMed
- [48] Larissa Lumi Watanabe Ishikawa et al.. Clin Rev Allergy Immunol. 2017. Vitamin D Deficiency and Rheumatoid Arthritis. doi:10.1007/s12016-016-8577-0 PubMed
- [49] Seval Erpolat et al.. Postepy Dermatol Alergol. 2017. 25-hydroxyvitamin D status in patients with alopecia areata. doi:10.5114/ada.2017.67847 PubMed
- [50] Ichiro Takada et al.. Curr Med Chem. 2017. Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands. doi:10.2174/0929867323666161202145509 PubMed
- [51] Jin Lin et al.. PLoS One. 2016. Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis. doi:10.1371/journal.pone.0146351 PubMed
- [52] Y Rosen et al.. Scand J Rheumatol. 2016. Vitamin D and autoimmunity. doi:10.3109/03009742.2016.1151072 PubMed
- [53] Ebru Karagün et al.. Postepy Dermatol Alergol. 2016. The role of serum vitamin D levels in vitiligo. doi:10.5114/pdia.2016.59507 PubMed
- [54] Ola Ahmed Bakry et al.. Indian Dermatol Online J. 2016. Serum Vitamin D in patients with alopecia areata. doi:10.4103/2229-5178.190504 PubMed
- [55] Berkeley N Limketkai et al.. Curr Gastroenterol Rep. 2016. Vitamin D and the Pathogenesis of Inflammatory Bowel Disease. doi:10.1007/s11894-016-0526-9 PubMed
- [56] Jiying Wang et al.. Nutrients. 2015. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. doi:10.3390/nu7042485 PubMed
- [57] Colleen Elizabeth Hayes et al.. Front Immunol. 2015. Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease. doi:10.3389/fimmu.2015.00100 PubMed
- [58] Aslı Aksu Çerman et al.. J Drugs Dermatol. 2015. Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study. PubMed
- [59] Maria O'Sullivan. Proc Nutr Soc. 2015. Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn? doi:10.1017/S0029665114001621 PubMed
- [60] Wen-Chih Liu et al.. Clin Chim Acta. 2015. Vitamin D and immune function in chronic kidney disease. doi:10.1016/j.cca.2015.08.011 PubMed
- [61] Aaron S Bancil et al.. Healthcare (Basel). 2015. The Role of Vitamin D in Inflammatory Bowel Disease. doi:10.3390/healthcare3020338 PubMed
- [62] Robyn M Lucas et al.. F1000Prime Rep. 2014. Vitamin D and immunity. doi:10.12703/P6-118 PubMed
- [63] Nanette B Silverberg. Pediatr Clin North Am. 2014. Pediatric vitiligo. doi:10.1016/j.pcl.2013.11.008 PubMed
- [64] Nancy Agmon-Levin et al.. Clin Rev Allergy Immunol. 2013. Vitamin D in systemic and organ-specific autoimmune diseases. doi:10.1007/s12016-012-8342-y PubMed
- [65] S Basit. Br J Biomed Sci. 2013. Vitamin D in health and disease: a literature review. doi:10.1080/09674845.2013.11669951 PubMed
- [66] Roberto d'Ovidio et al.. Dermatoendocrinol. 2013. Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata. doi:10.4161/derm.24411 PubMed
- [67] Daniel S Smyk et al.. Clin Res Hepatol Gastroenterol. 2013. Vitamin D in autoimmune liver disease. doi:10.1016/j.clinre.2013.05.016 PubMed
- [68] Alan Gaby. Glob Adv Health Med. 2013. Multiple sclerosis. doi:10.7453/gahmj.2013.2.1.009 PubMed
- [69] Yoland Schoindre et al.. Presse Med. 2013. [Vitamin D and autoimmunity]. doi:10.1016/j.lpm.2013.06.014 PubMed
- [70] Cynthia Aranow. J Investig Med. 2011. Vitamin D and the immune system. doi:10.2310/JIM.0b013e31821b8755 PubMed
- [71] Sandro Ardizzone et al.. Vitam Horm. 2011. Vitamin D and inflammatory bowel disease. doi:10.1016/B978-0-12-386960-9.00016-2 PubMed
- [72] Sinead Field et al.. Mol Oncol. 2011. Melanoma and vitamin D. doi:10.1016/j.molonc.2011.01.007 PubMed
- [73] Netta Shoenfeld et al.. Nat Clin Pract Rheumatol. 2009. The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. doi:10.1038/ncprheum0989 PubMed
- [74] Eka Ginanjar et al.. Acta Med Indones. 2007. Vitamin D and autoimmune disease. PubMed
- [75] Barbara L Mark et al.. J Am Diet Assoc. 2006. Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature. doi:10.1016/j.jada.2005.12.009 PubMed
- [76] Kelly M Luba et al.. Am Fam Physician. 2006. Chronic plaque psoriasis. PubMed
- [77] M T Cantorna. Proc Soc Exp Biol Med. 2000. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? doi:10.1046/j.1525-1373.2000.22333.x PubMed
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