Vitamin D cho Autoimmune Conditions
A Bằng chứng Nhiều thử nghiệm lâm sàng lớn liên tục cho thấy những lợi ích đáng kể.The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
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Kết luận
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
so với: None
Outcome: rheumatoid arthritis disease activity modulation through diet
Hiệu quả: None
None
Đối tượng nghiên cứu: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
so với: None
Outcome: RA risk and disease activity
Hiệu quả: None
None
Đối tượng nghiên cứu: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
so với: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
Hiệu quả: None
None
Đối tượng nghiên cứu: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
so với: None
Outcome: Neuroprotection
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Key Statistics
3
Nghiên cứu
25871
Người tham gia
↑
Positive
A
Xếp hạng
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 trích dẫn
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 trích dẫn
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 trích dẫn
Immunity & ageing …
2024
12 trích dẫn
Frontiers in immunology
2024
9 trích dẫn
Autoimmunity reviews
2024
6 trích dẫn
Biochemical pharmacology
2024
6 trích dẫn
Indian dermatology online …
2024
3 trích dẫn
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 trích dẫn
Biomolecules
2023
70 trích dẫn
Autoimmunity reviews
2023
65 trích dẫn
The American journal …
2023
37 trích dẫn
Frontiers in immunology
2023
33 trích dẫn
Nutrients
2023
24 trích dẫn
Seminars in arthritis …
2023
17 trích dẫn
Mini reviews in …
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9 trích dẫn
Journal of cosmetic …
2023
4 trích dẫn
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 trích dẫn
International journal of …
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102 trích dẫn
Endocrine connections
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50 trích dẫn
Nutrients
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29 trích dẫn
Pathophysiology : the …
2022
24 trích dẫn
Frontiers in bioscience …
2022
17 trích dẫn
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
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11 trích dẫn
BMJ (Clinical research …
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9 trích dẫn
Nederlands tijdschrift voor …
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International journal of …
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JAAD international
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Nutrients
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Nutrients
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Acta biochimica Polonica
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Advances in experimental …
2020
8 trích dẫn
Journal of autoimmunity
2019
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International journal of …
2019
109 trích dẫn
The genetics of vitamin D.
Review
Bone
2019
62 trích dẫn
Therapeutics and clinical …
2019
4 trích dẫn
Journal of research …
2018
48 trích dẫn
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 trích dẫn
Thyroid : official …
2017
170 trích dẫn
The Israel Medical …
2017
117 trích dẫn
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 trích dẫn
Clinical reviews in …
2017
46 trích dẫn
Postepy dermatologii i …
2017
31 trích dẫn
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 trích dẫn
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 trích dẫn
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 trích dẫn
Postepy dermatologii i …
2016
59 trích dẫn
Indian dermatology online …
2016
51 trích dẫn
Current gastroenterology reports
2016
22 trích dẫn
Nutrients
2015
210 trích dẫn
Frontiers in immunology
2015
102 trích dẫn
Journal of drugs …
2015
50 trích dẫn
The Proceedings of …
2015
46 trích dẫn
Clinica chimica acta; …
2015
43 trích dẫn
Healthcare (Basel, Switzerland)
2015
7 trích dẫn
Vitamin D and immunity.
Review
F1000prime reports
2014
79 trích dẫn
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 trích dẫn
Clinical reviews in …
2013
259 trích dẫn
British journal of …
2013
156 trích dẫn
Dermato-endocrinology
2013
62 trích dẫn
Clinics and research …
2013
56 trích dẫn
Multiple sclerosis.
Review
Global advances in …
2013
19 trích dẫn
Presse medicale (Paris, …
2013
4 trích dẫn
Journal of investigative …
2011
563 trích dẫn
Vitamins and hormones
2011
25 trích dẫn
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 trích dẫn
Acta medica Indonesiana
2007
4 trích dẫn
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 trích dẫn
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Giới hạn trên: 4,000 IU/day (100 mcg)
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
Thời điểm dùng tốt nhất: With a meal containing fat for better absorption
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Tương tác đã biết
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Mức hấp thụ tối đa cho phép: 4,000 IU/day (100 mcg)
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Autoimmune Conditions
Vitamin D cho các tình trạng khác
References
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