Conjugated Linoleic Acid para Chronic Inflammation

Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.

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Conclusión

Key Study Findings

Review

A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and …

Dose: None vs: None Outcome: None Efecto: None None

Población: Review of curcumin derivatives in cancer treatment

Review

Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.

Dose: None vs: None Outcome: None Efecto: None None

Población: review of dietary polyphenols in type 2 diabetes mellitus management

Review

Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects …

Dose: None vs: None Outcome: Musculoskeletal aging and cellular senescence Efecto: None None

Población: Aging adults with musculoskeletal decline (review)

Review

Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes.

Dose: 1% zinc chloride solution vs: None Outcome: Chronic epipharyngitis symptom improvement Efecto: None None

Población: Patients with chronic epipharyngitis (retracted publication)

Systematic Review

Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.

Dose: None vs: None Outcome: None Efecto: None None

Población: Review of TCM compounds in autoimmune skin diseases

Other

The omega effect: Harnessing fish oil for health.

Dose: None vs: None Outcome: None Efecto: None None

Población: None

Key Statistics

Estudios

150

Participantes

↔

Mixed

Calificación

Referenced Papers

Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. Review

Nutrients 2025 32 citas

Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise. Review

International journal of … 2025 5 citas

A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and analogs in cancer treatment (Review). Review

International journal of … 2025 2 citas

Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. Systematic Review

Frontiers in immunology 2025 1 citas

The omega effect: Harnessing fish oil for health. Other

Atherosclerosis 2025

Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes. Review

JMA journal 2025

Oral Lichen Planus: A Narrative Review Navigating Etiologies, Clinical Manifestations, Diagnostics, and Therapeutic Approaches. Review

Journal of clinical … 2024 29 citas

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. Other

Molecular nutrition & … 2024 15 citas

Milk Fat Globules: 2024 Updates. Other

Newborn (Clarksville, Md.) 2024 9 citas

From Structure to Function: How Prebiotic Diversity Shapes Gut Integrity and Immune Balance. Review

Nutrients 2024 7 citas

Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. RCT

Advances in rheumatology … 2024

Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage Polarization in Inflammatory Diseases. Review

Current molecular pharmacology 2023 72 citas

Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model. Other

Immunological investigations 2023 13 citas

Maresin1: A multifunctional regulator in inflammatory bone diseases. Review

International immunopharmacology 2023 8 citas

Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass. Review

International journal of … 2022 26 citas

Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials. Meta-Analysis

Biomolecular concepts 2022 18 citas

Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile. Other

Foods (Basel, Switzerland) 2022 9 citas

Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role? Review

Nutrients 2021 36 citas

Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. Other

Frontiers in medicine 2021 6 citas

Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. Other

Naunyn-Schmiedeberg's archives of … 2020 37 citas

Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. Other

Toxicology mechanisms and … 2019 33 citas

Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. RCT

Prostaglandins, leukotrienes, and … 2018 38 citas

MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol. Review

Medicines (Basel, Switzerland) 2018 23 citas

Curcumin: An Effective Inhibitor of Interleukin-6. Review

Current pharmaceutical design 2017 168 citas

A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model. Other

Lipids 2017 21 citas

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. Other

BMC medicine 2015 230 citas

Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with … RCT

Blood cells, molecules … 2015 53 citas

Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes. Other

Lipids 2012 28 citas

Individual isomers of conjugated linoleic acid reduce inflammation associated with established collagen-induced arthritis in DBA/1 mice. Other

The Journal of … 2010 32 citas

In vitro study of the effect of diesterified alkoxyglycerols with conjugated linoleic acid on adipocyte inflammatory mediators. Other

Lipids in health … 2010 7 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 1.5-3 g/day

Límite superior: No established UL

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
1% zinc chloride solution	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
200 mg	5 weeks	Positive	--
None	--	Positive	--

Mejor momento para tomar: With meals

Safety & Side Effects

Efectos secundarios reportados

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Fatigue
⚠ May worsen insulin sensitivity in some individuals
⚠ Liver fat accumulation (some formulations)

Interacciones conocidas

● Diabetes medications (may affect insulin sensitivity)
● Anticoagulants (may have additive effects)

Ingesta máxima tolerable: No established UL

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Conjugated Linoleic Acid help with Chronic Inflammation?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that Conjugated Linoleic Acid may support Chronic Inflammation management. Our evidence grade is D (Very Early Research).

How much Conjugated Linoleic Acid should I take for Chronic Inflammation?

Studies have used various dosages. A commonly studied range is 1.5-3 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Conjugated Linoleic Acid?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Conjugated Linoleic Acid and Chronic Inflammation?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

Related Evidence

Otros ingredientes para Chronic Inflammation

Omega-3 Fatty Acids (EPA/DHA) A Curcumin A Resveratrol C Chaga Mushroom D

Veredicto rápido

Evidence Strength30%

Low confidence

Desglose de estudios

RCT (3)Meta (1)Other (0)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Chronic Inflammation

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.