Glutathione for Post-Viral Fatigue
DIntracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.
The Bottom Line
Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.
Key Study Findings
Population: Aged C57BL/6J mice (73 weeks old)
Population: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)
Population: ME/CFS (n=27) and Long COVID (n=20) vs healthy controls
Population: Pacific white shrimp (L. vannamei) at high stocking density
Population: 16 healthy, 15 ME/CFS, 15 Long COVID donors
Population: Rat model
Key Statistics
3
Studies
100
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 250-500 mg/day
- immunesupport:
- 500-1,000 mg/day (liposomal preferred)
Upper limit: No established UL
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| 400 mg/kg/day | 8 weeks | Positive | -- |
| 21 g/day for 30 days | 4 weeks | Positive | 10 |
| None | -- | Positive | 72 |
| 0.2% supplementation | 8 weeks | Positive | 270 |
| None | -- | Negative | 46 |
| 34 g | -- | Positive | -- |
| Qiye Shen'an Pian + glutathione + vitamin B1 | -- | Positive | 106 |
| SELENOP autoantibodies (measured) | -- | Positive | -- |
Best taken: On empty stomach; liposomal forms have superior absorption
Safety & Side Effects
Reported Side Effects
- ⚠ Generally well tolerated
- ⚠ Bloating and cramping (oral form)
- ⚠ Allergic reactions (rare)
- ⚠ Zinc depletion with chronic high-dose use (theoretical)
Known Interactions
- ● Chemotherapy agents (may modify oxidative mechanisms; consult oncologist)
- ● Nitroglycerin (may enhance hypotensive effects)
Tolerable upper intake: No established UL
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Glutathione help with Post-Viral Fatigue?
How much Glutathione should I take for Post-Viral Fatigue?
Are there side effects of Glutathione?
How strong is the evidence for Glutathione and Post-Viral Fatigue?
Related Evidence
Other ingredients for Post-Viral Fatigue
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.