Glutathione ： Post-Viral Fatigue

Q: Does Glutathione help with Post-Viral Fatigue?

Based on 3 studies with 100 participants, there is preliminary evidence that needs more research that Glutathione may support Post-Viral Fatigue management. Our evidence grade is D (Very Early Research).

Q: How much Glutathione should I take for Post-Viral Fatigue?

Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Glutathione?

Reported side effects may include Generally well tolerated, Bloating and cramping (oral form), Allergic reactions (rare), Zinc depletion with chronic high-dose use (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Glutathione and Post-Viral Fatigue?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.

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結論

Key Study Findings

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp 効果: None None

対象集団: Pacific white shrimp (L. vannamei) at high stocking density

Controlled Clinical Trial 8 weeks

Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating …

Dose: 400 mg/kg/day vs: Aged mice without MSM Outcome: Trabecular bone volume and resorption markers 効果: None None

対象集団: Aged C57BL/6J mice (73 weeks old)

Controlled Clinical Trial n=10 4 weeks

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Dose: 21 g/day for 30 days vs: Control diet (no MSM), crossover design Outcome: Skeletal muscle inflammatory gene expression 効果: 630 exercise-responsive genes (MSM) vs 237 (CON) p<0.05

対象集団: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)

Observational Study n=72

Oxidative stress is a shared characteristic of ME/CFS and Long COVID.

Dose: None vs: Healthy controls (n=25) Outcome: Oxidative stress markers in lymphocytes 効果: None None

対象集団: ME/CFS (n=27) and Long COVID (n=20) vs healthy controls

Randomized Controlled Trial n=106

Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune …

Dose: Qiye Shen'an Pian + glutathione + vitamin B1 vs: Glutathione + vitamin B1 alone Outcome: Fatigue status, immune function, QoL 効果: None None

対象集団: CFS patients (106, 2021-2023)

Observational Study n=46

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID.

Dose: None vs: Healthy controls Outcome: Oxidative stress markers in ME/CFS and Long COVID 効果: None None

対象集団: 16 healthy, 15 ME/CFS, 15 Long COVID donors

Key Statistics

研究数

100

参加者数

↑

Positive

グレード

Referenced Papers

Oxidative stress is a shared characteristic of ME/CFS and Long COVID. Other

Proceedings of the … 2025 19 件の引用

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 件の引用

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. Other

Animals : an … 2025

Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating Oxidative Stress-Mediated Bone Resorption. Other

Antioxidants (Basel, Switzerland) 2025

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID. Other

bioRxiv : the … 2024 19 件の引用

Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota and metabolites in broilers. Other

Poultry science 2024 12 件の引用

Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life … Other

Alternative therapies in … 2024

Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone. Other

Redox biology 2023 24 件の引用

Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome. Other

Biomedical chromatography : … 2022 9 件の引用

Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious … Other

Molecular omics 2022 7 件の引用

Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla. Other

Psychopharmacology 2022 4 件の引用

COVID-19: A methyl-group assault? Other

Medical hypotheses 2021 24 件の引用

Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora. Other

Pharmaceutical biology 2021 15 件の引用

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome]. Review

Zhen ci yan … 2021 2 件の引用

International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients … Other

The World Allergy … 2020 135 件の引用

Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans? Other

Journal of the … 2020 43 件の引用

l-Cysteine and Vitamin D Co-Supplementation Alleviates Markers of Musculoskeletal Disorders in Vitamin D-Deficient High-Fat Diet-Fed Mice. Other

Nutrients 2020 12 件の引用

Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … Other

Biological trace element … 2020 10 件の引用

Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters. Other

Neurotoxicity research 2020 5 件の引用

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative … Other

Oxidative medicine and … 2018 45 件の引用

Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats. Other

BMC complementary and … 2018 27 件の引用

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. Review

Molecular neurobiology 2017 90 件の引用

Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity. Other

Journal of the … 2017 16 件の引用

Investigation of the effects of vanilloids in chronic fatigue syndrome. Other

Brain research bulletin 2016 6 件の引用

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. Other

BMC medicine 2015 230 件の引用

Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats. Other

Carbohydrate polymers 2015 75 件の引用

The glutathione system: a new drug target in neuroimmune disorders. Review

Molecular neurobiology 2014 190 件の引用

Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice. Other

Pharmacological reports : … 2014 21 件の引用

Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. Review

Journal of immunological … 2014 13 件の引用

The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome. Other

Archives of pharmacal … 2014

Role of reactive oxygen species and antioxidants in atopic dermatitis. Other

Journal of clinical … 2013 178 件の引用

Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder … Other

NMR in biomedicine 2012 175 件の引用

The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive … RCT

Journal of animal … 2012 8 件の引用

[Effect of acupuncture on serum malonaldehyde content, superoxide dismutase and glutathione peroxidase activity in chronic fatigue syndrome rats]. Other

Zhen ci yan … 2012 8 件の引用

The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. Review

International journal of … 2011 73 件の引用

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other

Indian journal of … 2011 11 件の引用

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway … Other

Neuro endocrinology letters 2011

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive … Other

Journal of neuroimmunology 2010 26 件の引用

[Effect of Tuina on oxygen free radicals metabolism in patients with chronic fatigue syndrome]. RCT

Zhongguo zhen jiu … 2010 15 件の引用

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations. Other

Fundamental & clinical … 2009 31 件の引用

Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence. Other

Behavioural brain research 2009 22 件の引用

An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome). CCT

Prostaglandins, leukotrienes, and … 2009 9 件の引用

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other

Pharmacological reports : … 2008

Erythrocyte oxidative damage in chronic fatigue syndrome. Other

Archives of medical … 2007 84 件の引用

Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. Other

Journal of internal … 2005 197 件の引用

Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice. Other

Journal of medicinal … 2005 40 件の引用

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis. Other

The International journal … 2003 39 件の引用

Isoprenoid pathway dysfunction in chronic fatigue syndrome. Other

Acta neuropsychiatrica 2003 15 件の引用

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. Other

Journal of medicinal … 2002 135 件の引用

Role of antioxidants in chronic fatigue syndrome in mice. Other

Indian journal of … 2002

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability. Review

Medical hypotheses 2001 34 件の引用

Chronic fatigue syndrome: oxidative stress and dietary modifications. Review

Alternative medicine review … 2001

Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome. Other

Free radical biology … 2000 187 件の引用

Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. Other

Journal of the … 2000 111 件の引用

Free radicals in chronic fatigue syndrome: cause or effect? Other

Redox report : … 2000 25 件の引用

Vitamin B status in patients with chronic fatigue syndrome. Other

Journal of the … 1999 36 件の引用

Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome. Other

Medical hypotheses 1999 33 件の引用

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. Review

FASEB journal : … 1997 170 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 250-500 mg/day
immunesupport:: 500-1,000 mg/day (liposomal preferred)

上限量： No established UL

研究で検討された用量

用量	期間	効果	N
0.2% supplementation	8 weeks	Positive	270
400 mg/kg/day	8 weeks	Positive	--
21 g/day for 30 days	4 weeks	Positive	10
None	--	Positive	72
Qiye Shen'an Pian + glutathione + vitamin B1	--	Positive	106
None	--	Negative	46
34 g	--	Positive	--
SELENOP autoantibodies (measured)	--	Positive	--

推奨摂取タイミング： On empty stomach; liposomal forms have superior absorption

Safety & Side Effects

報告されている副作用

⚠ Generally well tolerated
⚠ Bloating and cramping (oral form)
⚠ Allergic reactions (rare)
⚠ Zinc depletion with chronic high-dose use (theoretical)

既知の相互作用

● Chemotherapy agents (may modify oxidative mechanisms; consult oncologist)
● Nitroglycerin (may enhance hypotensive effects)

耐容上限摂取量： No established UL

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Glutathione help with Post-Viral Fatigue?

Based on 3 studies with 100 participants, there is preliminary evidence that needs more research that Glutathione may support Post-Viral Fatigue management. Our evidence grade is D (Very Early Research).

How much Glutathione should I take for Post-Viral Fatigue?

Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Glutathione?

Reported side effects may include Generally well tolerated, Bloating and cramping (oral form), Allergic reactions (rare), Zinc depletion with chronic high-dose use (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Glutathione and Post-Viral Fatigue?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Post-Viral Fatigue

N-Acetylcysteine C

総合評価

Evidence Strength30%

Low confidence

研究の内訳

RCT (2)Meta (0)Other (1)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Post-Viral Fatigue

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。