Glutathione ： Post-Viral Fatigue
D 研究 予備的な研究（実験室研究、症例報告）のみが存在します。Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.
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D
結論
Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.
Key Study Findings
Other
n=270
8 weeks
N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …
Dose: 0.2% supplementation
vs: Control diet at LSD and HSD
Outcome: Growth, immune and antioxidant response in shrimp
効果: None
None
対象集団: Pacific white shrimp (L. vannamei) at high stocking density
Controlled Clinical Trial
8 weeks
Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating …
Dose: 400 mg/kg/day
vs: Aged mice without MSM
Outcome: Trabecular bone volume and resorption markers
効果: None
None
対象集団: Aged C57BL/6J mice (73 weeks old)
Controlled Clinical Trial
n=10
4 weeks
Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.
Dose: 21 g/day for 30 days
vs: Control diet (no MSM), crossover design
Outcome: Skeletal muscle inflammatory gene expression
効果: 630 exercise-responsive genes (MSM) vs 237 (CON)
p<0.05
対象集団: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)
Observational Study
n=72
Oxidative stress is a shared characteristic of ME/CFS and Long COVID.
Dose: None
vs: Healthy controls (n=25)
Outcome: Oxidative stress markers in lymphocytes
効果: None
None
対象集団: ME/CFS (n=27) and Long COVID (n=20) vs healthy controls
Randomized Controlled Trial
n=106
Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune …
Dose: Qiye Shen'an Pian + glutathione + vitamin B1
vs: Glutathione + vitamin B1 alone
Outcome: Fatigue status, immune function, QoL
効果: None
None
対象集団: CFS patients (106, 2021-2023)
Observational Study
n=46
Oxidative Stress is a shared characteristic of ME/CFS and Long COVID.
Dose: None
vs: Healthy controls
Outcome: Oxidative stress markers in ME/CFS and Long COVID
効果: None
None
対象集団: 16 healthy, 15 ME/CFS, 15 Long COVID donors
Key Statistics
3
研究数
100
参加者数
↑
Positive
D
グレード
Referenced Papers
Proceedings of the …
2025
19 件の引用
PloS one
2025
5 件の引用
Animals : an …
2025
Antioxidants (Basel, Switzerland)
2025
bioRxiv : the …
2024
19 件の引用
Poultry science
2024
12 件の引用
Alternative therapies in …
2024
Redox biology
2023
24 件の引用
Biomedical chromatography : …
2022
9 件の引用
Molecular omics
2022
7 件の引用
Psychopharmacology
2022
4 件の引用
Medical hypotheses
2021
24 件の引用
Pharmaceutical biology
2021
15 件の引用
Zhen ci yan …
2021
2 件の引用
The World Allergy …
2020
135 件の引用
Journal of the …
2020
43 件の引用
Nutrients
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12 件の引用
Biological trace element …
2020
10 件の引用
Neurotoxicity research
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5 件の引用
Oxidative medicine and …
2018
45 件の引用
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27 件の引用
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2017
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Journal of the …
2017
16 件の引用
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2016
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2015
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2015
75 件の引用
Molecular neurobiology
2014
190 件の引用
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2014
21 件の引用
Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine.
Review
Journal of immunological …
2014
13 件の引用
The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome.
Other
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The International journal …
2003
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Acta neuropsychiatrica
2003
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Journal of medicinal …
2002
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Indian journal of …
2002
Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability.
Review
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2001
34 件の引用
Alternative medicine review …
2001
Free radical biology …
2000
187 件の引用
Journal of the …
2000
111 件の引用
Redox report : …
2000
25 件の引用
Journal of the …
1999
36 件の引用
Medical hypotheses
1999
33 件の引用
FASEB journal : …
1997
170 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 250-500 mg/day
- immunesupport:
- 500-1,000 mg/day (liposomal preferred)
上限量： No established UL
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| 0.2% supplementation | 8 weeks | Positive | 270 |
| 400 mg/kg/day | 8 weeks | Positive | -- |
| 21 g/day for 30 days | 4 weeks | Positive | 10 |
| None | -- | Positive | 72 |
| Qiye Shen'an Pian + glutathione + vitamin B1 | -- | Positive | 106 |
| None | -- | Negative | 46 |
| 34 g | -- | Positive | -- |
| SELENOP autoantibodies (measured) | -- | Positive | -- |
推奨摂取タイミング： On empty stomach; liposomal forms have superior absorption
Safety & Side Effects
報告されている副作用
- ⚠ Generally well tolerated
- ⚠ Bloating and cramping (oral form)
- ⚠ Allergic reactions (rare)
- ⚠ Zinc depletion with chronic high-dose use (theoretical)
既知の相互作用
- ● Chemotherapy agents (may modify oxidative mechanisms; consult oncologist)
- ● Nitroglycerin (may enhance hypotensive effects)
耐容上限摂取量： No established UL
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Glutathione help with Post-Viral Fatigue?
Based on 3 studies with 100 participants, there is preliminary evidence that needs more research that Glutathione may support Post-Viral Fatigue management. Our evidence grade is D (Very Early Research).
How much Glutathione should I take for Post-Viral Fatigue?
Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Glutathione?
Reported side effects may include Generally well tolerated, Bloating and cramping (oral form), Allergic reactions (rare), Zinc depletion with chronic high-dose use (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Glutathione and Post-Viral Fatigue?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Post-Viral Fatigue
References
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