Glutathione para Post-Viral Fatigue

Q: Does Glutathione help with Post-Viral Fatigue?

Based on 3 studies with 100 participants, there is preliminary evidence that needs more research that Glutathione may support Post-Viral Fatigue management. Our evidence grade is D (Very Early Research).

Q: How much Glutathione should I take for Post-Viral Fatigue?

Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Glutathione?

Reported side effects may include Generally well tolerated, Bloating and cramping (oral form), Allergic reactions (rare), Zinc depletion with chronic high-dose use (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Glutathione and Post-Viral Fatigue?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.

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Conclusión

Key Study Findings

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Efecto: None None

Población: Pacific white shrimp (L. vannamei) at high stocking density

Controlled Clinical Trial 8 weeks

Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating …

Dose: 400 mg/kg/day vs: Aged mice without MSM Outcome: Trabecular bone volume and resorption markers Efecto: None None

Población: Aged C57BL/6J mice (73 weeks old)

Controlled Clinical Trial n=10 4 weeks

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

Dose: 21 g/day for 30 days vs: Control diet (no MSM), crossover design Outcome: Skeletal muscle inflammatory gene expression Efecto: 630 exercise-responsive genes (MSM) vs 237 (CON) p<0.05

Población: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)

Observational Study n=72

Oxidative stress is a shared characteristic of ME/CFS and Long COVID.

Dose: None vs: Healthy controls (n=25) Outcome: Oxidative stress markers in lymphocytes Efecto: None None

Población: ME/CFS (n=27) and Long COVID (n=20) vs healthy controls

Randomized Controlled Trial n=106

Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune …

Dose: Qiye Shen'an Pian + glutathione + vitamin B1 vs: Glutathione + vitamin B1 alone Outcome: Fatigue status, immune function, QoL Efecto: None None

Población: CFS patients (106, 2021-2023)

Observational Study n=46

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID.

Dose: None vs: Healthy controls Outcome: Oxidative stress markers in ME/CFS and Long COVID Efecto: None None

Población: 16 healthy, 15 ME/CFS, 15 Long COVID donors

Key Statistics

Estudios

100

Participantes

↑

Positive

Calificación

Referenced Papers

Oxidative stress is a shared characteristic of ME/CFS and Long COVID. Other

Proceedings of the … 2025 19 citas

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 citas

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. Other

Animals : an … 2025

Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating Oxidative Stress-Mediated Bone Resorption. Other

Antioxidants (Basel, Switzerland) 2025

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID. Other

bioRxiv : the … 2024 19 citas

Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota and metabolites in broilers. Other

Poultry science 2024 12 citas

Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life … Other

Alternative therapies in … 2024

Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone. Other

Redox biology 2023 24 citas

Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome. Other

Biomedical chromatography : … 2022 9 citas

Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious … Other

Molecular omics 2022 7 citas

Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla. Other

Psychopharmacology 2022 4 citas

COVID-19: A methyl-group assault? Other

Medical hypotheses 2021 24 citas

Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora. Other

Pharmaceutical biology 2021 15 citas

[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome]. Review

Zhen ci yan … 2021 2 citas

International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients … Other

The World Allergy … 2020 135 citas

Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans? Other

Journal of the … 2020 43 citas

l-Cysteine and Vitamin D Co-Supplementation Alleviates Markers of Musculoskeletal Disorders in Vitamin D-Deficient High-Fat Diet-Fed Mice. Other

Nutrients 2020 12 citas

Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … Other

Biological trace element … 2020 10 citas

Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters. Other

Neurotoxicity research 2020 5 citas

Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative … Other

Oxidative medicine and … 2018 45 citas

Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats. Other

BMC complementary and … 2018 27 citas

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. Review

Molecular neurobiology 2017 90 citas

Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity. Other

Journal of the … 2017 16 citas

Investigation of the effects of vanilloids in chronic fatigue syndrome. Other

Brain research bulletin 2016 6 citas

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. Other

BMC medicine 2015 230 citas

Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats. Other

Carbohydrate polymers 2015 75 citas

The glutathione system: a new drug target in neuroimmune disorders. Review

Molecular neurobiology 2014 190 citas

Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice. Other

Pharmacological reports : … 2014 21 citas

Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. Review

Journal of immunological … 2014 13 citas

The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome. Other

Archives of pharmacal … 2014

Role of reactive oxygen species and antioxidants in atopic dermatitis. Other

Journal of clinical … 2013 178 citas

Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder … Other

NMR in biomedicine 2012 175 citas

The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive … RCT

Journal of animal … 2012 8 citas

[Effect of acupuncture on serum malonaldehyde content, superoxide dismutase and glutathione peroxidase activity in chronic fatigue syndrome rats]. Other

Zhen ci yan … 2012 8 citas

The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. Review

International journal of … 2011 73 citas

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other

Indian journal of … 2011 11 citas

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway … Other

Neuro endocrinology letters 2011

Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive … Other

Journal of neuroimmunology 2010 26 citas

[Effect of Tuina on oxygen free radicals metabolism in patients with chronic fatigue syndrome]. RCT

Zhongguo zhen jiu … 2010 15 citas

Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations. Other

Fundamental & clinical … 2009 31 citas

Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence. Other

Behavioural brain research 2009 22 citas

An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome). CCT

Prostaglandins, leukotrienes, and … 2009 9 citas

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other

Pharmacological reports : … 2008

Erythrocyte oxidative damage in chronic fatigue syndrome. Other

Archives of medical … 2007 84 citas

Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. Other

Journal of internal … 2005 197 citas

Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice. Other

Journal of medicinal … 2005 40 citas

Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis. Other

The International journal … 2003 39 citas

Isoprenoid pathway dysfunction in chronic fatigue syndrome. Other

Acta neuropsychiatrica 2003 15 citas

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. Other

Journal of medicinal … 2002 135 citas

Role of antioxidants in chronic fatigue syndrome in mice. Other

Indian journal of … 2002

Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability. Review

Medical hypotheses 2001 34 citas

Chronic fatigue syndrome: oxidative stress and dietary modifications. Review

Alternative medicine review … 2001

Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome. Other

Free radical biology … 2000 187 citas

Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. Other

Journal of the … 2000 111 citas

Free radicals in chronic fatigue syndrome: cause or effect? Other

Redox report : … 2000 25 citas

Vitamin B status in patients with chronic fatigue syndrome. Other

Journal of the … 1999 36 citas

Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome. Other

Medical hypotheses 1999 33 citas

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. Review

FASEB journal : … 1997 170 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 250-500 mg/day
immunesupport:: 500-1,000 mg/day (liposomal preferred)

Límite superior: No established UL

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
0.2% supplementation	8 weeks	Positive	270
400 mg/kg/day	8 weeks	Positive	--
21 g/day for 30 days	4 weeks	Positive	10
None	--	Positive	72
Qiye Shen'an Pian + glutathione + vitamin B1	--	Positive	106
None	--	Negative	46
34 g	--	Positive	--
SELENOP autoantibodies (measured)	--	Positive	--

Mejor momento para tomar: On empty stomach; liposomal forms have superior absorption

Safety & Side Effects

Efectos secundarios reportados

⚠ Generally well tolerated
⚠ Bloating and cramping (oral form)
⚠ Allergic reactions (rare)
⚠ Zinc depletion with chronic high-dose use (theoretical)

Interacciones conocidas

● Chemotherapy agents (may modify oxidative mechanisms; consult oncologist)
● Nitroglycerin (may enhance hypotensive effects)

Ingesta máxima tolerable: No established UL

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Glutathione help with Post-Viral Fatigue?

Based on 3 studies with 100 participants, there is preliminary evidence that needs more research that Glutathione may support Post-Viral Fatigue management. Our evidence grade is D (Very Early Research).

How much Glutathione should I take for Post-Viral Fatigue?

Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Glutathione?

Reported side effects may include Generally well tolerated, Bloating and cramping (oral form), Allergic reactions (rare), Zinc depletion with chronic high-dose use (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Glutathione and Post-Viral Fatigue?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Post-Viral Fatigue

N-Acetylcysteine C

Veredicto rápido

Evidence Strength30%

Low confidence

Desglose de estudios

RCT (2)Meta (0)Other (1)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Post-Viral Fatigue

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.