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Glutathione para Post-Viral Fatigue

D Investigación Solo existe investigación preliminar (estudios de laboratorio, informes de casos).

Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.

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D

Conclusión

Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.

Key Study Findings

Other n=270 8 weeks
N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …
Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Efecto: None None

Población: Pacific white shrimp (L. vannamei) at high stocking density

Controlled Clinical Trial 8 weeks
Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating …
Dose: 400 mg/kg/day vs: Aged mice without MSM Outcome: Trabecular bone volume and resorption markers Efecto: None None

Población: Aged C57BL/6J mice (73 weeks old)

Controlled Clinical Trial n=10 4 weeks
Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.
Dose: 21 g/day for 30 days vs: Control diet (no MSM), crossover design Outcome: Skeletal muscle inflammatory gene expression Efecto: 630 exercise-responsive genes (MSM) vs 237 (CON) p<0.05

Población: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)

Observational Study n=72
Oxidative stress is a shared characteristic of ME/CFS and Long COVID.
Dose: None vs: Healthy controls (n=25) Outcome: Oxidative stress markers in lymphocytes Efecto: None None

Población: ME/CFS (n=27) and Long COVID (n=20) vs healthy controls

Randomized Controlled Trial n=106
Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune …
Dose: Qiye Shen'an Pian + glutathione + vitamin B1 vs: Glutathione + vitamin B1 alone Outcome: Fatigue status, immune function, QoL Efecto: None None

Población: CFS patients (106, 2021-2023)

Observational Study n=46
Oxidative Stress is a shared characteristic of ME/CFS and Long COVID.
Dose: None vs: Healthy controls Outcome: Oxidative stress markers in ME/CFS and Long COVID Efecto: None None

Población: 16 healthy, 15 ME/CFS, 15 Long COVID donors

Key Statistics

3

Estudios

100

Participantes

Positive

D

Calificación

Referenced Papers

Medical hypotheses 2021 24 citas
Archives of medical … 2007 84 citas
Acta neuropsychiatrica 2003 15 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:
250-500 mg/day
immunesupport:
500-1,000 mg/day (liposomal preferred)

Límite superior: No established UL

Dosificaciones estudiadas en la investigación

Dosificación Duración Efecto N
0.2% supplementation 8 weeks Positive 270
400 mg/kg/day 8 weeks Positive --
21 g/day for 30 days 4 weeks Positive 10
None -- Positive 72
Qiye Shen'an Pian + glutathione + vitamin B1 -- Positive 106
None -- Negative 46
34 g -- Positive --
SELENOP autoantibodies (measured) -- Positive --

Mejor momento para tomar: On empty stomach; liposomal forms have superior absorption

Safety & Side Effects

Efectos secundarios reportados

  • Generally well tolerated
  • Bloating and cramping (oral form)
  • Allergic reactions (rare)
  • Zinc depletion with chronic high-dose use (theoretical)

Interacciones conocidas

  • Chemotherapy agents (may modify oxidative mechanisms; consult oncologist)
  • Nitroglycerin (may enhance hypotensive effects)

Ingesta máxima tolerable: No established UL

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Glutathione help with Post-Viral Fatigue?
Based on 3 studies with 100 participants, there is preliminary evidence that needs more research that Glutathione may support Post-Viral Fatigue management. Our evidence grade is D (Very Early Research).
How much Glutathione should I take for Post-Viral Fatigue?
Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Glutathione?
Reported side effects may include Generally well tolerated, Bloating and cramping (oral form), Allergic reactions (rare), Zinc depletion with chronic high-dose use (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Glutathione and Post-Viral Fatigue?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Otros ingredientes para Post-Viral Fatigue

References

  1. [1] Vishnu Shankar et al.. Proc Natl Acad Sci U S A. 2025. Oxidative stress is a shared characteristic of ME/CFS and Long COVID. doi:10.1073/pnas.2426564122 PubMed
  2. [2] Shafaq Fatima. PLoS One. 2025. N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … doi:10.1371/journal.pone.0315819 PubMed
  3. [3] Madison R Barshick et al.. Animals (Basel). 2025. Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. doi:10.3390/ani15020215 PubMed
  4. [4] Duo Zhang et al.. Antioxidants (Basel). 2025. Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating Oxidative Stress-Mediated Bone Resorption. doi:10.3390/antiox14020216 PubMed
  5. [5] Vishnu Shankar et al.. bioRxiv. 2024. Oxidative Stress is a shared characteristic of ME/CFS and Long COVID. doi:10.1101/2024.05.04.592477 PubMed
  6. [6] Jingxin Ouyang et al.. Poult Sci. 2024. Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota and metabolites in broilers. doi:10.1016/j.psj.2024.104202 PubMed
  7. [7] Jun Liu et al.. Altern Ther Health Med. 2024. Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life … PubMed
  8. [8] Qian Sun et al.. Redox Biol. 2023. Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone. doi:10.1016/j.redox.2023.102796 PubMed
  9. [9] Xiaoyao Miao et al.. Biomed Chromatogr. 2022. Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome. doi:10.1002/bmc.5379 PubMed
  10. [10] Leonard A Jason et al.. Mol Omics. 2022. Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious … doi:10.1039/d2mo00124a PubMed
  11. [11] Beata R Godlewska et al.. Psychopharmacology (Berl). 2022. Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla. doi:10.1007/s00213-021-05986-6 PubMed
  12. [12] Andrew McCaddon et al.. Med Hypotheses. 2021. COVID-19: A methyl-group assault? doi:10.1016/j.mehy.2021.110543 PubMed
  13. [13] Da-Ae Kwon et al.. Pharm Biol. 2021. Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora. doi:10.1080/13880209.2021.1900878 PubMed
  14. [14] Yan-Hui Li et al.. Zhen Ci Yan Jiu. 2021. [Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome]. doi:10.13702/j.1000-0607.200998 PubMed
  15. [15] Robert Naclerio et al.. World Allergy Organ J. 2020. International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients … doi:10.1016/j.waojou.2020.100106 PubMed
  16. [16] Sushil K Jain et al.. J Am Coll Nutr. 2020. Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans? doi:10.1080/07315724.2020.1789518 PubMed
  17. [17] Rajesh Parsanathan et al.. Nutrients. 2020. l-Cysteine and Vitamin D Co-Supplementation Alleviates Markers of Musculoskeletal Disorders in Vitamin D-Deficient High-Fat Diet-Fed Mice. doi:10.3390/nu12113406 PubMed
  18. [18] Akram Zarbalizadeh-Saed et al.. Biol Trace Elem Res. 2020. Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … doi:10.1007/s12011-019-01853-w PubMed
  19. [19] Vandana Thakur et al.. Neurotox Res. 2020. Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters. doi:10.1007/s12640-020-00231-y PubMed
  20. [20] Xue Wang et al.. Oxid Med Cell Longev. 2018. Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative … doi:10.1155/2018/9140896 PubMed
  21. [21] Hyun-Jung Park et al.. BMC Complement Altern Med. 2018. Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats. doi:10.1186/s12906-018-2193-x PubMed
  22. [22] Gerwyn Morris et al.. Mol Neurobiol. 2017. Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. doi:10.1007/s12035-016-9975-2 PubMed
  23. [23] Benjamin H Natelson et al.. J Neurol Sci. 2017. Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity. doi:10.1016/j.jns.2017.02.046 PubMed
  24. [24] Kuldeep Sarvaiya et al.. Brain Res Bull. 2016. Investigation of the effects of vanilloids in chronic fatigue syndrome. doi:10.1016/j.brainresbull.2016.09.015 PubMed
  25. [25] Gerwyn Morris et al.. BMC Med. 2015. The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. doi:10.1186/s12916-015-0310-y PubMed
  26. [26] Aiping Chi et al.. Carbohydr Polym. 2015. Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats. doi:10.1016/j.carbpol.2014.12.082 PubMed
  27. [27] Gerwyn Morris et al.. Mol Neurobiol. 2014. The glutathione system: a new drug target in neuroimmune disorders. doi:10.1007/s12035-014-8705-x PubMed
  28. [28] Mamta Sachdeva Dhingra et al.. Pharmacol Rep. 2014. Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice. doi:10.1016/j.pharep.2014.01.004 PubMed
  29. [29] Robert E Click. J Immunol Methods. 2014. Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. doi:10.1016/j.jim.2013.11.007 PubMed
  30. [30] Jia Wang et al.. Arch Pharm Res. 2014. The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome. doi:10.1007/s12272-013-0235-y PubMed
  31. [31] N Sivaranjani et al.. J Clin Diagn Res. 2013. Role of reactive oxygen species and antioxidants in atopic dermatitis. doi:10.7860/JCDR/2013/6635.3732 PubMed
  32. [32] Dikoma C Shungu et al.. NMR Biomed. 2012. Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder … doi:10.1002/nbm.2772 PubMed
  33. [33] D Lackeyram et al.. J Anim Sci. 2012. The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive … doi:10.2527/jas.54011 PubMed
  34. [34] Chang-Zheng Liu et al.. Zhen Ci Yan Jiu. 2012. [Effect of acupuncture on serum malonaldehyde content, superoxide dismutase and glutathione peroxidase activity in chronic fatigue syndrome rats]. PubMed
  35. [35] Chiara De Luca et al.. Int J Environ Res Public Health. 2011. The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. doi:10.3390/ijerph8072770 PubMed
  36. [36] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
  37. [37] Michael Maes et al.. Neuro Endocrinol Lett. 2011. Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway … PubMed
  38. [38] Amit Gupta et al.. J Neuroimmunol. 2010. Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive … doi:10.1016/j.jneuroim.2010.05.021 PubMed
  39. [39] Chang-Zheng Liu et al.. Zhongguo Zhen Jiu. 2010. [Effect of Tuina on oxygen free radicals metabolism in patients with chronic fatigue syndrome]. PubMed
  40. [40] Anil Kumar et al.. Fundam Clin Pharmacol. 2009. Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations. doi:10.1111/j.1472-8206.2008.00638.x PubMed
  41. [41] Anand Kamal Sachdeva et al.. Behav Brain Res. 2009. Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence. doi:10.1016/j.bbr.2009.07.020 PubMed
  42. [42] B K Puri et al.. Prostaglandins Leukot Essent Fatty Acids. 2009. An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome). doi:10.1016/j.plefa.2009.10.002 PubMed
  43. [43] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
  44. [44] Ross S Richards et al.. Arch Med Res. 2007. Erythrocyte oxidative damage in chronic fatigue syndrome. doi:10.1016/j.arcmed.2006.06.008 PubMed
  45. [45] Y Jammes et al.. J Intern Med. 2005. Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. doi:10.1111/j.1365-2796.2005.01452.x PubMed
  46. [46] Anjali Singal et al.. J Med Food. 2005. Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice. doi:10.1089/jmf.2005.8.47 PubMed
  47. [47] Ravi Kumar Kurup et al.. Int J Neurosci. 2003. Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis. doi:10.1080/00207450390200026 PubMed
  48. [48] Ravi Kumar Kurup et al.. Acta Neuropsychiatr. 2003. Isoprenoid pathway dysfunction in chronic fatigue syndrome. doi:10.1034/j.1601-5215.2003.00045.x PubMed
  49. [49] Amanpreet Singh et al.. J Med Food. 2002. Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. doi:10.1089/109662002763003366 PubMed
  50. [50] Amanpreet Singh et al.. Indian J Exp Biol. 2002. Role of antioxidants in chronic fatigue syndrome in mice. PubMed
  51. [51] A C Bested et al.. Med Hypotheses. 2001. Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability. doi:10.1054/mehy.2001.1306 PubMed
  52. [52] A C Logan et al.. Altern Med Rev. 2001. Chronic fatigue syndrome: oxidative stress and dietary modifications. PubMed
  53. [53] S Fulle et al.. Free Radic Biol Med. 2000. Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome. doi:10.1016/s0891-5849(00)00419-6 PubMed
  54. [54] B Manuel y Keenoy et al.. J Am Coll Nutr. 2000. Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. doi:10.1080/07315724.2000.10718934 PubMed
  55. [55] R S Richards et al.. Redox Rep. 2000. Free radicals in chronic fatigue syndrome: cause or effect? doi:10.1179/135100000101535519 PubMed
  56. [56] L C Heap et al.. J R Soc Med. 1999. Vitamin B status in patients with chronic fatigue syndrome. doi:10.1177/014107689909200405 PubMed
  57. [57] G Bounous et al.. Med Hypotheses. 1999. Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome. doi:10.1054/mehy.1998.0780 PubMed
  58. [58] W Dröge et al.. FASEB J. 1997. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. doi:10.1096/fasebj.11.13.9367343 PubMed

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.