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Glutathione für Post-Viral Fatigue

D

Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.

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D

Fazit

Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.

Key Study Findings

Other n=270 8 weeks
N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …
Dose: 0.2% supplementation vs.: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Wirkung: None None

Population: Pacific white shrimp (L. vannamei) at high stocking density

Controlled Clinical Trial 8 weeks
Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating …
Dose: 400 mg/kg/day vs.: Aged mice without MSM Outcome: Trabecular bone volume and resorption markers Wirkung: None None

Population: Aged C57BL/6J mice (73 weeks old)

Controlled Clinical Trial n=10 4 weeks
Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.
Dose: 21 g/day for 30 days vs.: Control diet (no MSM), crossover design Outcome: Skeletal muscle inflammatory gene expression Wirkung: 630 exercise-responsive genes (MSM) vs 237 (CON) p<0.05

Population: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)

Observational Study n=72
Oxidative stress is a shared characteristic of ME/CFS and Long COVID.
Dose: None vs.: Healthy controls (n=25) Outcome: Oxidative stress markers in lymphocytes Wirkung: None None

Population: ME/CFS (n=27) and Long COVID (n=20) vs healthy controls

Randomized Controlled Trial n=106
Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune …
Dose: Qiye Shen'an Pian + glutathione + vitamin B1 vs.: Glutathione + vitamin B1 alone Outcome: Fatigue status, immune function, QoL Wirkung: None None

Population: CFS patients (106, 2021-2023)

Observational Study n=46
Oxidative Stress is a shared characteristic of ME/CFS and Long COVID.
Dose: None vs.: Healthy controls Outcome: Oxidative stress markers in ME/CFS and Long COVID Wirkung: None None

Population: 16 healthy, 15 ME/CFS, 15 Long COVID donors

Key Statistics

3

Studien

100

Teilnehmer

Positive

D

Bewertung

Referenced Papers

Proceedings of the … 2025 19 Zitierungen
Medical hypotheses 2021 24 Zitierungen
Brain research bulletin 2016 6 Zitierungen
Molecular neurobiology 2014 190 Zitierungen
Journal of clinical … 2013 178 Zitierungen
Archives of medical … 2007 84 Zitierungen
The International journal … 2003 39 Zitierungen
Acta neuropsychiatrica 2003 15 Zitierungen
Redox report : … 2000 25 Zitierungen
Journal of the … 1999 36 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
250-500 mg/day
immunesupport:
500-1,000 mg/day (liposomal preferred)

Obergrenze: No established UL

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
0.2% supplementation 8 weeks Positive 270
400 mg/kg/day 8 weeks Positive --
21 g/day for 30 days 4 weeks Positive 10
None -- Positive 72
Qiye Shen'an Pian + glutathione + vitamin B1 -- Positive 106
None -- Negative 46
34 g -- Positive --
SELENOP autoantibodies (measured) -- Positive --

Beste Einnahmezeit: On empty stomach; liposomal forms have superior absorption

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Generally well tolerated
  • Bloating and cramping (oral form)
  • Allergic reactions (rare)
  • Zinc depletion with chronic high-dose use (theoretical)

Bekannte Wechselwirkungen

  • Chemotherapy agents (may modify oxidative mechanisms; consult oncologist)
  • Nitroglycerin (may enhance hypotensive effects)

Tolerierbare Höchstaufnahmemenge: No established UL

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Glutathione help with Post-Viral Fatigue?
Based on 3 studies with 100 participants, there is preliminary evidence that needs more research that Glutathione may support Post-Viral Fatigue management. Our evidence grade is D (Very Early Research).
How much Glutathione should I take for Post-Viral Fatigue?
Studies have used various dosages. A commonly studied range is 250-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Glutathione?
Reported side effects may include Generally well tolerated, Bloating and cramping (oral form), Allergic reactions (rare), Zinc depletion with chronic high-dose use (theoretical). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Glutathione and Post-Viral Fatigue?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.

Related Evidence

Andere Inhaltsstoffe für Post-Viral Fatigue

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