N-Acetylcysteine für Post-Viral Fatigue

C Evidenz Begrenzte Evidenz aus kleinen Studien, aber es gibt einige positive Signale.

Ongoing clinical trials are investigating NAC for long COVID and post-viral fatigue. NAC supplementation is associated with lower inflammation markers and may support glutathione replenishment in individuals with persistent oxidative stress following viral infection.

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Fazit

Key Study Findings

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs.: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Wirkung: None None

Population: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None vs.: GK15 induction without NAC Outcome: hPGCLC induction efficiency Wirkung: None None

Population: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) vs.: None Outcome: Pain and inflammation in rheumatic diseases Wirkung: None None

Population: Patients with rheumatic diseases

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet vs.: Placebo Wirkung: None None

Randomized Controlled Trial

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among …

Dose: None vs.: None Outcome: Phosphatidylethanol (PEth) levels Wirkung: None None

Population: None

randomized controlled trial (veterinary) n=120 3 weeks

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens.

Dose: 1000 mg/kg in basal diet vs.: Placebo Wirkung: None None

Key Statistics

Studien

400

Teilnehmer

↑

Positive

Bewertung

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 Zitierungen

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 Zitierungen

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 Zitierungen

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 Zitierungen

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 Zitierungen

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 Zitierungen

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. Review

Molecular neurobiology 2017 90 Zitierungen

The glutathione system: a new drug target in neuroimmune disorders. Review

Molecular neurobiology 2014 190 Zitierungen

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 Zitierungen

Chronic fatigue syndrome: oxidative stress and dietary modifications. Review

Alternative medicine review … 2001

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

Obergrenze: No established UL; doses up to 1,800 mg/day widely studied

In der Forschung untersuchte Dosierungen

Dosierung	Dauer	Wirkung	N
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120
NAC 100 mg/kg body weight orally daily for 14 days	2 weeks	Positive	24
None	--	Mixed	--

Beste Einnahmezeit: Between meals on empty stomach for optimal absorption

Safety & Side Effects

Gemeldete Nebenwirkungen

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

Bekannte Wechselwirkungen

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

Tolerierbare Höchstaufnahmemenge: No established UL; doses up to 1,800 mg/day widely studied

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does N-Acetylcysteine help with Post-Viral Fatigue?

Based on 5 studies with 400 participants, there is limited but promising evidence that N-Acetylcysteine may support Post-Viral Fatigue management. Our evidence grade is C (Some Evidence).

How much N-Acetylcysteine should I take for Post-Viral Fatigue?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Post-Viral Fatigue?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Andere Inhaltsstoffe für Post-Viral Fatigue

Glutathione D

N-Acetylcysteine für andere Beschwerden

Acute Bronchitis B

Kurzfazit

Evidence Strength52%

Moderate confidence

Studienübersicht

RCT (2)Meta (0)Other (3)

Alternativen vergleichen

Sehen Sie, wie andere Inhaltsstoffe bei dieser Beschwerde abschneiden.

Alle Inhaltsstoffe ansehen für Post-Viral Fatigue

Mehr erfahren

References

[1] Shafaq Fatima. PLoS One. 2025. N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … doi:10.1371/journal.pone.0315819 PubMed
[2] Gege Yuan et al.. J Biomed Res. 2025. Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. doi:10.7555/JBR.38.20240433 PubMed
[3] Mary-Ann Fitzcharles et al.. Arthritis Care Res (Hoboken). 2023. Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. doi:10.1002/acr.24176 PubMed
[4] Xianhong Cao et al.. Poult Sci. 2023. Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. doi:10.1016/j.psj.2022.102274 PubMed
[5] Matthew F McLaughlin et al.. Alcohol Clin Exp Res. 2022. Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … doi:10.1111/acer.14891 PubMed
[6] Yulan Zhao et al.. J Therm Biol. 2021. Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. doi:10.1016/j.jtherbio.2021.102927 PubMed
[7] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
[8] Gerwyn Morris et al.. Mol Neurobiol. 2017. Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. doi:10.1007/s12035-016-9975-2 PubMed
[9] Gerwyn Morris et al.. Mol Neurobiol. 2014. The glutathione system: a new drug target in neuroimmune disorders. doi:10.1007/s12035-014-8705-x PubMed
[10] Yao Sun et al.. Cardiovasc Res. 2006. Oxidative stress in aldosteronism. doi:10.1016/j.cardiores.2006.03.007 PubMed
[11] A C Logan et al.. Altern Med Rev. 2001. Chronic fatigue syndrome: oxidative stress and dietary modifications. PubMed

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