N-Acetylcysteine 用于 病毒感染后疲劳
C 证据 来自小型研究的证据有限，但存在一些积极信号。Ongoing clinical trials are investigating NAC for long COVID and post-viral fatigue. NAC supplementation is associated with lower inflammation markers and may support glutathione replenishment in individuals with persistent oxidative stress following viral infection.
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C
结论
Ongoing clinical trials are investigating NAC for long COVID and post-viral fatigue. NAC supplementation is associated with lower inflammation markers and may support glutathione replenishment in individuals with persistent oxidative stress following viral infection.
Key Study Findings
Other
n=270
8 weeks
N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …
Dose: 0.2% supplementation
vs: Control diet at LSD and HSD
Outcome: Growth, immune and antioxidant response in shrimp
效果: None
None
研究人群: Pacific white shrimp (L. vannamei) at high stocking density
In Vitro
Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …
Dose: None
vs: GK15 induction without NAC
Outcome: hPGCLC induction efficiency
效果: None
None
研究人群: Human iPSCs (in vitro)
Review
Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.
Dose: Cannabidiol (CBD)
vs: None
Outcome: Pain and inflammation in rheumatic diseases
效果: None
None
研究人群: Patients with rheumatic diseases
animal study (controlled experiment)
n=120
3 weeks
Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …
Dose: 1 g/kg NAC in basal diet
vs: Placebo
效果: None
None
Randomized Controlled Trial
Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among …
Dose: None
vs: None
Outcome: Phosphatidylethanol (PEth) levels
效果: None
None
研究人群: None
randomized controlled trial (veterinary)
n=120
3 weeks
Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens.
Dose: 1000 mg/kg in basal diet
vs: Placebo
效果: None
None
Key Statistics
5
研究数量
400
受试者
↑
Positive
C
等级
Referenced Papers
PloS one
2025
5 次引用
Journal of biomedical …
2025
Arthritis care & …
2023
36 次引用
Poultry science
2023
13 次引用
Alcoholism, clinical and …
2022
4 次引用
Journal of thermal …
2021
24 次引用
N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
Other
Canadian journal of …
2018
37 次引用
Molecular neurobiology
2017
90 次引用
Molecular neurobiology
2014
190 次引用
Cardiovascular research
2006
42 次引用
Alternative medicine review …
2001
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 600-1,200 mg/day
- respiratorysupport:
- 600 mg 2-3x/day
上限： No established UL; doses up to 1,800 mg/day widely studied
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| 0.2% supplementation | 8 weeks | Positive | 270 |
| None | -- | Positive | -- |
| Cannabidiol (CBD) | -- | Mixed | -- |
| 1 g/kg NAC in basal diet | 3 weeks | Positive | 120 |
| None | -- | Mixed | -- |
| 1000 mg/kg in basal diet | 3 weeks | Positive | 120 |
| NAC 100 mg/kg body weight orally daily for 14 days | 2 weeks | Positive | 24 |
| None | -- | Mixed | -- |
最佳服用时间： Between meals on empty stomach for optimal absorption
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Unpleasant sulfur taste/smell
- ⚠ Headache
- ⚠ Rare: bronchospasm (in asthma patients, inhaled form)
已知相互作用
- ● Nitroglycerin (may enhance vasodilatory and headache effects)
- ● Activated charcoal (reduces NAC absorption)
- ● Anticoagulants (theoretical effect on platelet function)
可耐受最高摄入量： No established UL; doses up to 1,800 mg/day widely studied
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does N-Acetylcysteine help with 病毒感染后疲劳?
Based on 5 studies with 400 participants, there is limited but promising evidence that N-Acetylcysteine may support 病毒感染后疲劳 management. Our evidence grade is C (Some Evidence).
How much N-Acetylcysteine should I take for 病毒感染后疲劳?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetylcysteine?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetylcysteine and 病毒感染后疲劳?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 病毒感染后疲劳
N-Acetylcysteine 用于其他健康状况
References
- [1] Shafaq Fatima. PLoS One. 2025. N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … doi:10.1371/journal.pone.0315819 PubMed
- [2] Gege Yuan et al.. J Biomed Res. 2025. Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. doi:10.7555/JBR.38.20240433 PubMed
- [3] Mary-Ann Fitzcharles et al.. Arthritis Care Res (Hoboken). 2023. Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. doi:10.1002/acr.24176 PubMed
- [4] Xianhong Cao et al.. Poult Sci. 2023. Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. doi:10.1016/j.psj.2022.102274 PubMed
- [5] Matthew F McLaughlin et al.. Alcohol Clin Exp Res. 2022. Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … doi:10.1111/acer.14891 PubMed
- [6] Yulan Zhao et al.. J Therm Biol. 2021. Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. doi:10.1016/j.jtherbio.2021.102927 PubMed
- [7] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
- [8] Gerwyn Morris et al.. Mol Neurobiol. 2017. Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. doi:10.1007/s12035-016-9975-2 PubMed
- [9] Gerwyn Morris et al.. Mol Neurobiol. 2014. The glutathione system: a new drug target in neuroimmune disorders. doi:10.1007/s12035-014-8705-x PubMed
- [10] Yao Sun et al.. Cardiovasc Res. 2006. Oxidative stress in aldosteronism. doi:10.1016/j.cardiores.2006.03.007 PubMed
- [11] A C Logan et al.. Altern Med Rev. 2001. Chronic fatigue syndrome: oxidative stress and dietary modifications. PubMed
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