N-Acetylcysteine untuk Post-Viral Fatigue

Ongoing clinical trials are investigating NAC for long COVID and post-viral fatigue. NAC supplementation is associated with lower inflammation markers and may support glutathione replenishment in individuals with persistent oxidative stress following viral infection.

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Kesimpulan

Key Study Findings

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Efek: None None

Populasi: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None vs: GK15 induction without NAC Outcome: hPGCLC induction efficiency Efek: None None

Populasi: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) vs: None Outcome: Pain and inflammation in rheumatic diseases Efek: None None

Populasi: Patients with rheumatic diseases

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet vs: Placebo Efek: None None

Randomized Controlled Trial

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among …

Dose: None vs: None Outcome: Phosphatidylethanol (PEth) levels Efek: None None

Populasi: None

randomized controlled trial (veterinary) n=120 3 weeks

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens.

Dose: 1000 mg/kg in basal diet vs: Placebo Efek: None None

Key Statistics

Studi

400

Peserta

↑

Positive

Peringkat

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 sitasi

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 sitasi

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 sitasi

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 sitasi

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 sitasi

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 sitasi

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. Review

Molecular neurobiology 2017 90 sitasi

The glutathione system: a new drug target in neuroimmune disorders. Review

Molecular neurobiology 2014 190 sitasi

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 sitasi

Chronic fatigue syndrome: oxidative stress and dietary modifications. Review

Alternative medicine review … 2001

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

Batas atas: No established UL; doses up to 1,800 mg/day widely studied

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120
NAC 100 mg/kg body weight orally daily for 14 days	2 weeks	Positive	24
None	--	Mixed	--

Waktu terbaik diminum: Between meals on empty stomach for optimal absorption

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

Interaksi yang Diketahui

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

Asupan atas yang dapat ditoleransi: No established UL; doses up to 1,800 mg/day widely studied

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does N-Acetylcysteine help with Post-Viral Fatigue?

Based on 5 studies with 400 participants, there is limited but promising evidence that N-Acetylcysteine may support Post-Viral Fatigue management. Our evidence grade is C (Some Evidence).

How much N-Acetylcysteine should I take for Post-Viral Fatigue?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Post-Viral Fatigue?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Post-Viral Fatigue

Glutathione D

N-Acetylcysteine untuk kondisi lain

Acute Bronchitis B

Kesimpulan Singkat

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (2)Meta (0)Other (3)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Post-Viral Fatigue

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.