N-Acetylcysteine لـ Post-Viral Fatigue

Ongoing clinical trials are investigating NAC for long COVID and post-viral fatigue. NAC supplementation is associated with lower inflammation markers and may support glutathione replenishment in individuals with persistent oxidative stress following viral infection.

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الخلاصة

Key Study Findings

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation مقابل: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp التأثير: None None

المجتمع المدروس: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None مقابل: GK15 induction without NAC Outcome: hPGCLC induction efficiency التأثير: None None

المجتمع المدروس: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) مقابل: None Outcome: Pain and inflammation in rheumatic diseases التأثير: None None

المجتمع المدروس: Patients with rheumatic diseases

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet مقابل: Placebo التأثير: None None

Randomized Controlled Trial

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among …

Dose: None مقابل: None Outcome: Phosphatidylethanol (PEth) levels التأثير: None None

المجتمع المدروس: None

randomized controlled trial (veterinary) n=120 3 weeks

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens.

Dose: 1000 mg/kg in basal diet مقابل: Placebo التأثير: None None

Key Statistics

الدراسات

400

المشاركون

↑

Positive

التقييم

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 اقتباسات

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 اقتباسات

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 اقتباسات

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 اقتباسات

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 اقتباسات

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 اقتباسات

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. Review

Molecular neurobiology 2017 90 اقتباسات

The glutathione system: a new drug target in neuroimmune disorders. Review

Molecular neurobiology 2014 190 اقتباسات

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 اقتباسات

Chronic fatigue syndrome: oxidative stress and dietary modifications. Review

Alternative medicine review … 2001

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

الحد الأعلى: No established UL; doses up to 1,800 mg/day widely studied

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120
NAC 100 mg/kg body weight orally daily for 14 days	2 weeks	Positive	24
None	--	Mixed	--

أفضل وقت للتناول: Between meals on empty stomach for optimal absorption

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

التفاعلات المعروفة

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

الحد الأقصى المسموح به: No established UL; doses up to 1,800 mg/day widely studied

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does N-Acetylcysteine help with Post-Viral Fatigue?

Based on 5 studies with 400 participants, there is limited but promising evidence that N-Acetylcysteine may support Post-Viral Fatigue management. Our evidence grade is C (Some Evidence).

How much N-Acetylcysteine should I take for Post-Viral Fatigue?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Post-Viral Fatigue?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Post-Viral Fatigue

Glutathione D

N-Acetylcysteine لحالات أخرى

Acute Bronchitis B

الخلاصة السريعة

Evidence Strength52%

Moderate confidence

تفصيل الدراسات

RCT (2)Meta (0)Other (3)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Post-Viral Fatigue

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.