N-Acetylcysteine ： Post-Viral Fatigue

Ongoing clinical trials are investigating NAC for long COVID and post-viral fatigue. NAC supplementation is associated with lower inflammation markers and may support glutathione replenishment in individuals with persistent oxidative stress following viral infection.

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結論

Key Study Findings

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp 効果: None None

対象集団: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None vs: GK15 induction without NAC Outcome: hPGCLC induction efficiency 効果: None None

対象集団: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) vs: None Outcome: Pain and inflammation in rheumatic diseases 効果: None None

対象集団: Patients with rheumatic diseases

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet vs: Placebo 効果: None None

Randomized Controlled Trial

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among …

Dose: None vs: None Outcome: Phosphatidylethanol (PEth) levels 効果: None None

対象集団: None

randomized controlled trial (veterinary) n=120 3 weeks

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens.

Dose: 1000 mg/kg in basal diet vs: Placebo 効果: None None

Key Statistics

研究数

400

参加者数

↑

Positive

グレード

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 件の引用

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 件の引用

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 件の引用

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 件の引用

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 件の引用

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 件の引用

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. Review

Molecular neurobiology 2017 90 件の引用

The glutathione system: a new drug target in neuroimmune disorders. Review

Molecular neurobiology 2014 190 件の引用

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 件の引用

Chronic fatigue syndrome: oxidative stress and dietary modifications. Review

Alternative medicine review … 2001

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

上限量： No established UL; doses up to 1,800 mg/day widely studied

研究で検討された用量

用量	期間	効果	N
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120
NAC 100 mg/kg body weight orally daily for 14 days	2 weeks	Positive	24
None	--	Mixed	--

推奨摂取タイミング： Between meals on empty stomach for optimal absorption

Safety & Side Effects

報告されている副作用

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

既知の相互作用

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

耐容上限摂取量： No established UL; doses up to 1,800 mg/day widely studied

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does N-Acetylcysteine help with Post-Viral Fatigue?

Based on 5 studies with 400 participants, there is limited but promising evidence that N-Acetylcysteine may support Post-Viral Fatigue management. Our evidence grade is C (Some Evidence).

How much N-Acetylcysteine should I take for Post-Viral Fatigue?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Post-Viral Fatigue?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Post-Viral Fatigue

Glutathione D

N-Acetylcysteine 他の症状・状態について

Acute Bronchitis B

総合評価

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (2)Meta (0)Other (3)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Post-Viral Fatigue

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。