N-Acetylcysteine لـ Acute Bronchitis

Q: Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

Q: How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Meta-analyses associate NAC supplementation with lower inflammatory markers and improved oxygenation in respiratory patients. Its well-established mucolytic properties support airway clearance in acute bronchitis. NAC is an FDA-approved mucolytic agent with a long safety record.

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الخلاصة

Key Study Findings

Review

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care.

Dose: 20 mg/kg/day acute; 200 mg TID chronic مقابل: None Outcome: Efficacy in pediatric respiratory diseases التأثير: None None

المجتمع المدروس: Children with acute/chronic respiratory diseases

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation مقابل: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp التأثير: None None

المجتمع المدروس: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None مقابل: GK15 induction without NAC Outcome: hPGCLC induction efficiency التأثير: None None

المجتمع المدروس: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) مقابل: None Outcome: Pain and inflammation in rheumatic diseases التأثير: None None

المجتمع المدروس: Patients with rheumatic diseases

Randomized Controlled Trial n=333 1.0 weeks Double-blind

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion.

Dose: 600 mg مقابل: placebo and ambroxol Outcome: Sputum viscosity and expectoration difficulty التأثير: None p<0.001

المجتمع المدروس: Patients with respiratory disease and abnormal mucus

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet مقابل: Placebo التأثير: None None

Key Statistics

الدراسات

1500

المشاركون

↑

Positive

التقييم

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 اقتباسات

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. Review

Drugs in context 2025 1 اقتباسات

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 اقتباسات

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 اقتباسات

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion. RCT

European review for … 2023 2 اقتباسات

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 اقتباسات

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 اقتباسات

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 اقتباسات

Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. Other

Natural product communications 2011 7 اقتباسات

Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Meta-Analysis

Phytomedicine : international … 2008 100 اقتباسات

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 اقتباسات

Respiratory and allergic diseases: from upper respiratory tract infections to asthma. Review

Primary care 2002 56 اقتباسات

[Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. Review

Polski merkuriusz lekarski … 2002 16 اقتباسات

The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. RCT

Respirology (Carlton, Vic.) 1998 14 اقتباسات

[Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]. Other

Fortschritte der Medizin 1992

[Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. Other

Fortschritte der Medizin 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

الحد الأعلى: No established UL; doses up to 1,800 mg/day widely studied

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
20 mg/kg/day acute; 200 mg TID chronic	--	Positive	--
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
600 mg	1.0 weeks	Mixed	333
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120

أفضل وقت للتناول: Between meals on empty stomach for optimal absorption

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

التفاعلات المعروفة

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

الحد الأقصى المسموح به: No established UL; doses up to 1,800 mg/day widely studied

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Acute Bronchitis

Pelargonium sidoides A

N-Acetylcysteine لحالات أخرى

Post-Viral Fatigue C

الخلاصة السريعة

Evidence Strength72%

High confidence

تفصيل الدراسات

RCT (4)Meta (1)Other (5)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Acute Bronchitis

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.