N-Acetylcysteine cho Acute Bronchitis

Q: Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

Q: How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

B Bằng chứng Ít nhất một thử nghiệm ngẫu nhiên ủng hộ điều này, với các kết quả phần lớn nhất quán.

Meta-analyses associate NAC supplementation with lower inflammatory markers and improved oxygenation in respiratory patients. Its well-established mucolytic properties support airway clearance in acute bronchitis. NAC is an FDA-approved mucolytic agent with a long safety record.

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Kết luận

Key Study Findings

Review

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care.

Dose: 20 mg/kg/day acute; 200 mg TID chronic so với: None Outcome: Efficacy in pediatric respiratory diseases Hiệu quả: None None

Đối tượng nghiên cứu: Children with acute/chronic respiratory diseases

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation so với: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Hiệu quả: None None

Đối tượng nghiên cứu: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None so với: GK15 induction without NAC Outcome: hPGCLC induction efficiency Hiệu quả: None None

Đối tượng nghiên cứu: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) so với: None Outcome: Pain and inflammation in rheumatic diseases Hiệu quả: None None

Đối tượng nghiên cứu: Patients with rheumatic diseases

Randomized Controlled Trial n=333 1.0 weeks Double-blind

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion.

Dose: 600 mg so với: placebo and ambroxol Outcome: Sputum viscosity and expectoration difficulty Hiệu quả: None p<0.001

Đối tượng nghiên cứu: Patients with respiratory disease and abnormal mucus

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet so với: Placebo Hiệu quả: None None

Key Statistics

Nghiên cứu

1500

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 trích dẫn

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. Review

Drugs in context 2025 1 trích dẫn

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 trích dẫn

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 trích dẫn

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion. RCT

European review for … 2023 2 trích dẫn

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 trích dẫn

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 trích dẫn

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 trích dẫn

Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. Other

Natural product communications 2011 7 trích dẫn

Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Meta-Analysis

Phytomedicine : international … 2008 100 trích dẫn

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 trích dẫn

Respiratory and allergic diseases: from upper respiratory tract infections to asthma. Review

Primary care 2002 56 trích dẫn

[Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. Review

Polski merkuriusz lekarski … 2002 16 trích dẫn

The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. RCT

Respirology (Carlton, Vic.) 1998 14 trích dẫn

[Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]. Other

Fortschritte der Medizin 1992

[Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. Other

Fortschritte der Medizin 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

Giới hạn trên: No established UL; doses up to 1,800 mg/day widely studied

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
20 mg/kg/day acute; 200 mg TID chronic	--	Positive	--
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
600 mg	1.0 weeks	Mixed	333
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120

Thời điểm dùng tốt nhất: Between meals on empty stomach for optimal absorption

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

Tương tác đã biết

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

Mức hấp thụ tối đa cho phép: No established UL; doses up to 1,800 mg/day widely studied

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Các thành phần khác cho Acute Bronchitis

Pelargonium sidoides A

N-Acetylcysteine cho các tình trạng khác

Post-Viral Fatigue C

Đánh giá nhanh

Evidence Strength72%

High confidence

Phân tích nghiên cứu

RCT (4)Meta (1)Other (5)

So sánh lựa chọn thay thế

Xem các thành phần khác so sánh như thế nào cho tình trạng này.

Xem tất cả thành phần cho Acute Bronchitis

Tìm hiểu thêm

References

[1] Shafaq Fatima. PLoS One. 2025. N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … doi:10.1371/journal.pone.0315819 PubMed
[2] Francesca Benedetti et al.. Drugs Context. 2025. N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. doi:10.7573/dic.2025-7-7 PubMed
[3] Gege Yuan et al.. J Biomed Res. 2025. Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. doi:10.7555/JBR.38.20240433 PubMed
[4] Mary-Ann Fitzcharles et al.. Arthritis Care Res (Hoboken). 2023. Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. doi:10.1002/acr.24176 PubMed
[5] Xianhong Cao et al.. Poult Sci. 2023. Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. doi:10.1016/j.psj.2022.102274 PubMed
[6] W Tang et al.. Eur Rev Med Pharmacol Sci. 2023. Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion. doi:10.26355/eurrev_202306_32628 PubMed
[7] Matthew F McLaughlin et al.. Alcohol Clin Exp Res. 2022. Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … doi:10.1111/acer.14891 PubMed
[8] Yulan Zhao et al.. J Therm Biol. 2021. Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. doi:10.1016/j.jtherbio.2021.102927 PubMed
[9] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
[10] Jie Ma et al.. Nat Prod Commun. 2011. Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. PubMed
[11] Taofikat B Agbabiaka et al.. Phytomedicine. 2008. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. doi:10.1016/j.phymed.2007.11.023 PubMed
[12] Yao Sun et al.. Cardiovasc Res. 2006. Oxidative stress in aldosteronism. doi:10.1016/j.cardiores.2006.03.007 PubMed
[13] Raja Jaber. Prim Care. 2002. Respiratory and allergic diseases: from upper respiratory tract infections to asthma. doi:10.1016/s0095-4543(01)00008-2 PubMed
[14] Maciej Kupczyk et al.. Pol Merkur Lekarski. 2002. [Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. PubMed
[15] P Soepandi et al.. Respirology. 1998. The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. doi:10.1111/j.1440-1843.1998.tb00108.x PubMed
[16] K P Völkl et al.. Fortschr Med. 1992. [Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]. PubMed
[17] H H Gerards et al.. Fortschr Med. 1991. [Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. PubMed

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