N-Acetylcysteine के लिए Acute Bronchitis
B संबंधित साक्ष्य कम से कम एक यादृच्छिक परीक्षण इसका समर्थन करता है, जिसके परिणाम अधिकतर सुसंगत हैं।Meta-analyses associate NAC supplementation with lower inflammatory markers and improved oxygenation in respiratory patients. Its well-established mucolytic properties support airway clearance in acute bronchitis. NAC is an FDA-approved mucolytic agent with a long safety record.
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B
निष्कर्ष
Meta-analyses associate NAC supplementation with lower inflammatory markers and improved oxygenation in respiratory patients. Its well-established mucolytic properties support airway clearance in acute bronchitis. NAC is an FDA-approved mucolytic agent with a long safety record.
Key Study Findings
Review
N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care.
Dose: 20 mg/kg/day acute; 200 mg TID chronic
बनाम: None
Outcome: Efficacy in pediatric respiratory diseases
प्रभाव: None
None
जनसंख्या: Children with acute/chronic respiratory diseases
Other
n=270
8 weeks
N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …
Dose: 0.2% supplementation
बनाम: Control diet at LSD and HSD
Outcome: Growth, immune and antioxidant response in shrimp
प्रभाव: None
None
जनसंख्या: Pacific white shrimp (L. vannamei) at high stocking density
In Vitro
Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …
Dose: None
बनाम: GK15 induction without NAC
Outcome: hPGCLC induction efficiency
प्रभाव: None
None
जनसंख्या: Human iPSCs (in vitro)
Review
Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.
Dose: Cannabidiol (CBD)
बनाम: None
Outcome: Pain and inflammation in rheumatic diseases
प्रभाव: None
None
जनसंख्या: Patients with rheumatic diseases
Randomized Controlled Trial
n=333
1.0 weeks
Double-blind
Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion.
Dose: 600 mg
बनाम: placebo and ambroxol
Outcome: Sputum viscosity and expectoration difficulty
प्रभाव: None
p<0.001
जनसंख्या: Patients with respiratory disease and abnormal mucus
animal study (controlled experiment)
n=120
3 weeks
Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …
Dose: 1 g/kg NAC in basal diet
बनाम: Placebo
प्रभाव: None
None
Key Statistics
10
अध्ययन
1500
प्रतिभागी
↑
Positive
B
ग्रेड
Referenced Papers
PloS one
2025
5 उद्धरण
Drugs in context
2025
1 उद्धरण
Journal of biomedical …
2025
Arthritis care & …
2023
36 उद्धरण
Poultry science
2023
13 उद्धरण
European review for …
2023
2 उद्धरण
Alcoholism, clinical and …
2022
4 उद्धरण
Journal of thermal …
2021
24 उद्धरण
N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
Other
Canadian journal of …
2018
37 उद्धरण
Natural product communications
2011
7 उद्धरण
Phytomedicine : international …
2008
100 उद्धरण
Cardiovascular research
2006
42 उद्धरण
Primary care
2002
56 उद्धरण
Polski merkuriusz lekarski …
2002
16 उद्धरण
Respirology (Carlton, Vic.)
1998
14 उद्धरण
Fortschritte der Medizin
1992
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
सामान्य रूप से उपयोग की जाने वाली खुराकें
- general:
- 600-1,200 mg/day
- respiratorysupport:
- 600 mg 2-3x/day
अधिकतम सीमा: No established UL; doses up to 1,800 mg/day widely studied
अनुसंधान में अध्ययन की गई खुराकें
| खुराक | अवधि | प्रभाव | N |
|---|---|---|---|
| 20 mg/kg/day acute; 200 mg TID chronic | -- | Positive | -- |
| 0.2% supplementation | 8 weeks | Positive | 270 |
| None | -- | Positive | -- |
| Cannabidiol (CBD) | -- | Mixed | -- |
| 600 mg | 1.0 weeks | Mixed | 333 |
| 1 g/kg NAC in basal diet | 3 weeks | Positive | 120 |
| None | -- | Mixed | -- |
| 1000 mg/kg in basal diet | 3 weeks | Positive | 120 |
सेवन का सर्वोत्तम समय: Between meals on empty stomach for optimal absorption
Safety & Side Effects
रिपोर्ट किए गए दुष्प्रभाव
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Unpleasant sulfur taste/smell
- ⚠ Headache
- ⚠ Rare: bronchospasm (in asthma patients, inhaled form)
ज्ञात अंतःक्रियाएँ
- ● Nitroglycerin (may enhance vasodilatory and headache effects)
- ● Activated charcoal (reduces NAC absorption)
- ● Anticoagulants (theoretical effect on platelet function)
सहनीय अधिकतम सेवन: No established UL; doses up to 1,800 mg/day widely studied
कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।
Frequently Asked Questions
Does N-Acetylcysteine help with Acute Bronchitis?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).
How much N-Acetylcysteine should I take for Acute Bronchitis?
Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetylcysteine?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
इसके लिए अन्य सामग्री Acute Bronchitis
N-Acetylcysteine अन्य स्वास्थ्य स्थितियों के लिए
References
- [1] Shafaq Fatima. PLoS One. 2025. N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … doi:10.1371/journal.pone.0315819 PubMed
- [2] Francesca Benedetti et al.. Drugs Context. 2025. N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. doi:10.7573/dic.2025-7-7 PubMed
- [3] Gege Yuan et al.. J Biomed Res. 2025. Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. doi:10.7555/JBR.38.20240433 PubMed
- [4] Mary-Ann Fitzcharles et al.. Arthritis Care Res (Hoboken). 2023. Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. doi:10.1002/acr.24176 PubMed
- [5] Xianhong Cao et al.. Poult Sci. 2023. Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. doi:10.1016/j.psj.2022.102274 PubMed
- [6] W Tang et al.. Eur Rev Med Pharmacol Sci. 2023. Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion. doi:10.26355/eurrev_202306_32628 PubMed
- [7] Matthew F McLaughlin et al.. Alcohol Clin Exp Res. 2022. Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … doi:10.1111/acer.14891 PubMed
- [8] Yulan Zhao et al.. J Therm Biol. 2021. Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. doi:10.1016/j.jtherbio.2021.102927 PubMed
- [9] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
- [10] Jie Ma et al.. Nat Prod Commun. 2011. Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. PubMed
- [11] Taofikat B Agbabiaka et al.. Phytomedicine. 2008. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. doi:10.1016/j.phymed.2007.11.023 PubMed
- [12] Yao Sun et al.. Cardiovasc Res. 2006. Oxidative stress in aldosteronism. doi:10.1016/j.cardiores.2006.03.007 PubMed
- [13] Raja Jaber. Prim Care. 2002. Respiratory and allergic diseases: from upper respiratory tract infections to asthma. doi:10.1016/s0095-4543(01)00008-2 PubMed
- [14] Maciej Kupczyk et al.. Pol Merkur Lekarski. 2002. [Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. PubMed
- [15] P Soepandi et al.. Respirology. 1998. The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. doi:10.1111/j.1440-1843.1998.tb00108.x PubMed
- [16] K P Völkl et al.. Fortschr Med. 1992. [Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]. PubMed
- [17] H H Gerards et al.. Fortschr Med. 1991. [Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. PubMed
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