N-Acetylcysteine para Acute Bronchitis

Q: Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

Q: How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Meta-analyses associate NAC supplementation with lower inflammatory markers and improved oxygenation in respiratory patients. Its well-established mucolytic properties support airway clearance in acute bronchitis. NAC is an FDA-approved mucolytic agent with a long safety record.

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Conclusão

Key Study Findings

Review

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care.

Dose: 20 mg/kg/day acute; 200 mg TID chronic vs: None Outcome: Efficacy in pediatric respiratory diseases Efeito: None None

População: Children with acute/chronic respiratory diseases

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Efeito: None None

População: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None vs: GK15 induction without NAC Outcome: hPGCLC induction efficiency Efeito: None None

População: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) vs: None Outcome: Pain and inflammation in rheumatic diseases Efeito: None None

População: Patients with rheumatic diseases

Randomized Controlled Trial n=333 1.0 weeks Double-blind

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion.

Dose: 600 mg vs: placebo and ambroxol Outcome: Sputum viscosity and expectoration difficulty Efeito: None p<0.001

População: Patients with respiratory disease and abnormal mucus

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet vs: Placebo Efeito: None None

Key Statistics

Estudos

1500

Participantes

↑

Positive

Nota

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 citações

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. Review

Drugs in context 2025 1 citações

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 citações

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 citações

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion. RCT

European review for … 2023 2 citações

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 citações

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 citações

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 citações

Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. Other

Natural product communications 2011 7 citações

Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Meta-Analysis

Phytomedicine : international … 2008 100 citações

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 citações

Respiratory and allergic diseases: from upper respiratory tract infections to asthma. Review

Primary care 2002 56 citações

[Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. Review

Polski merkuriusz lekarski … 2002 16 citações

The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. RCT

Respirology (Carlton, Vic.) 1998 14 citações

[Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]. Other

Fortschritte der Medizin 1992

[Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. Other

Fortschritte der Medizin 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

Limite superior: No established UL; doses up to 1,800 mg/day widely studied

Dosagens Estudadas em Pesquisas

Dosagem	Duração	Efeito	N
20 mg/kg/day acute; 200 mg TID chronic	--	Positive	--
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
600 mg	1.0 weeks	Mixed	333
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120

Melhor horário: Between meals on empty stomach for optimal absorption

Safety & Side Effects

Efeitos Colaterais Relatados

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

Interações Conhecidas

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

Ingestão máxima tolerável: No established UL; doses up to 1,800 mg/day widely studied

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Acute Bronchitis

Pelargonium sidoides A

N-Acetylcysteine para outras condições

Post-Viral Fatigue C

Veredito Rápido

Evidence Strength72%

High confidence

Detalhamento dos Estudos

RCT (4)Meta (1)Other (5)

Comparar Alternativas

Veja como outros ingredientes se comparam para esta condição.

Ver todos os ingredientes para Acute Bronchitis

Saiba Mais

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.