N-Acetylcysteine untuk Acute Bronchitis

Q: Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

Q: How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

B Bukti Setidaknya satu uji coba acak mendukung hal ini, dengan hasil yang sebagian besar konsisten.

Meta-analyses associate NAC supplementation with lower inflammatory markers and improved oxygenation in respiratory patients. Its well-established mucolytic properties support airway clearance in acute bronchitis. NAC is an FDA-approved mucolytic agent with a long safety record.

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Kesimpulan

Key Study Findings

Review

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care.

Dose: 20 mg/kg/day acute; 200 mg TID chronic vs: None Outcome: Efficacy in pediatric respiratory diseases Efek: None None

Populasi: Children with acute/chronic respiratory diseases

Other n=270 8 weeks

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp …

Dose: 0.2% supplementation vs: Control diet at LSD and HSD Outcome: Growth, immune and antioxidant response in shrimp Efek: None None

Populasi: Pacific white shrimp (L. vannamei) at high stocking density

In Vitro

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based …

Dose: None vs: GK15 induction without NAC Outcome: hPGCLC induction efficiency Efek: None None

Populasi: Human iPSCs (in vitro)

Review

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care.

Dose: Cannabidiol (CBD) vs: None Outcome: Pain and inflammation in rheumatic diseases Efek: None None

Populasi: Patients with rheumatic diseases

Randomized Controlled Trial n=333 1.0 weeks Double-blind

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion.

Dose: 600 mg vs: placebo and ambroxol Outcome: Sputum viscosity and expectoration difficulty Efek: None p<0.001

Populasi: Patients with respiratory disease and abnormal mucus

animal study (controlled experiment) n=120 3 weeks

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of …

Dose: 1 g/kg NAC in basal diet vs: Placebo Efek: None None

Key Statistics

Studi

1500

Peserta

↑

Positive

Peringkat

Referenced Papers

N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … Other

PloS one 2025 5 sitasi

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. Review

Drugs in context 2025 1 sitasi

Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. Other

Journal of biomedical … 2025

Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. Review

Arthritis care & … 2023 36 sitasi

Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. Other

Poultry science 2023 13 sitasi

Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion. RCT

European review for … 2023 2 sitasi

Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … RCT

Alcoholism, clinical and … 2022 4 sitasi

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. RCT

Journal of thermal … 2021 24 sitasi

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 sitasi

Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. Other

Natural product communications 2011 7 sitasi

Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Meta-Analysis

Phytomedicine : international … 2008 100 sitasi

Oxidative stress in aldosteronism. Review

Cardiovascular research 2006 42 sitasi

Respiratory and allergic diseases: from upper respiratory tract infections to asthma. Review

Primary care 2002 56 sitasi

[Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. Review

Polski merkuriusz lekarski … 2002 16 sitasi

The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. RCT

Respirology (Carlton, Vic.) 1998 14 sitasi

[Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]. Other

Fortschritte der Medizin 1992

[Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. Other

Fortschritte der Medizin 1991

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 600-1,200 mg/day
respiratorysupport:: 600 mg 2-3x/day

Batas atas: No established UL; doses up to 1,800 mg/day widely studied

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
20 mg/kg/day acute; 200 mg TID chronic	--	Positive	--
0.2% supplementation	8 weeks	Positive	270
None	--	Positive	--
Cannabidiol (CBD)	--	Mixed	--
600 mg	1.0 weeks	Mixed	333
1 g/kg NAC in basal diet	3 weeks	Positive	120
None	--	Mixed	--
1000 mg/kg in basal diet	3 weeks	Positive	120

Waktu terbaik diminum: Between meals on empty stomach for optimal absorption

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Unpleasant sulfur taste/smell
⚠ Headache
⚠ Rare: bronchospasm (in asthma patients, inhaled form)

Interaksi yang Diketahui

● Nitroglycerin (may enhance vasodilatory and headache effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical effect on platelet function)

Asupan atas yang dapat ditoleransi: No established UL; doses up to 1,800 mg/day widely studied

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does N-Acetylcysteine help with Acute Bronchitis?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that N-Acetylcysteine may support Acute Bronchitis management. Our evidence grade is B (Good Evidence).

How much N-Acetylcysteine should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 600-1,200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetylcysteine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Unpleasant sulfur taste/smell, Headache, Rare: bronchospasm (in asthma patients, inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetylcysteine and Acute Bronchitis?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Bahan lain untuk Acute Bronchitis

Pelargonium sidoides A

N-Acetylcysteine untuk kondisi lain

Post-Viral Fatigue C

Kesimpulan Singkat

Evidence Strength72%

High confidence

Rincian Studi

RCT (4)Meta (1)Other (5)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Acute Bronchitis

Pelajari Lebih Lanjut

References

[1] Shafaq Fatima. PLoS One. 2025. N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … doi:10.1371/journal.pone.0315819 PubMed
[2] Francesca Benedetti et al.. Drugs Context. 2025. N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. doi:10.7573/dic.2025-7-7 PubMed
[3] Gege Yuan et al.. J Biomed Res. 2025. Improving in vitro induction efficiency of human primordial germ cell-like cells using N2B27 or NAC-based medium. doi:10.7555/JBR.38.20240433 PubMed
[4] Mary-Ann Fitzcharles et al.. Arthritis Care Res (Hoboken). 2023. Cautious Hope for Cannabidiol (CBD) in Rheumatology Care. doi:10.1002/acr.24176 PubMed
[5] Xianhong Cao et al.. Poult Sci. 2023. Effects of N-acetyl-l-cysteine on chronic heat stress-induced oxidative stress and inflammation in the ovaries of growing pullets. doi:10.1016/j.psj.2022.102274 PubMed
[6] W Tang et al.. Eur Rev Med Pharmacol Sci. 2023. Intravenous N-acetylcysteine in respiratory disease with abnormal mucus secretion. doi:10.26355/eurrev_202306_32628 PubMed
[7] Matthew F McLaughlin et al.. Alcohol Clin Exp Res. 2022. Correlates of high phosphatidylethanol (PEth) levels and their concordance with self-reported heavy alcohol consumption among men who have sex with … doi:10.1111/acer.14891 PubMed
[8] Yulan Zhao et al.. J Therm Biol. 2021. Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens. doi:10.1016/j.jtherbio.2021.102927 PubMed
[9] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
[10] Jie Ma et al.. Nat Prod Commun. 2011. Simultaneous quantification of Echinacea species, Flos Lonicerae, Radix Scutellaria and Fructus Forsythiae combinations by rapid resolution liquid chromatography. PubMed
[11] Taofikat B Agbabiaka et al.. Phytomedicine. 2008. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. doi:10.1016/j.phymed.2007.11.023 PubMed
[12] Yao Sun et al.. Cardiovasc Res. 2006. Oxidative stress in aldosteronism. doi:10.1016/j.cardiores.2006.03.007 PubMed
[13] Raja Jaber. Prim Care. 2002. Respiratory and allergic diseases: from upper respiratory tract infections to asthma. doi:10.1016/s0095-4543(01)00008-2 PubMed
[14] Maciej Kupczyk et al.. Pol Merkur Lekarski. 2002. [Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]. PubMed
[15] P Soepandi et al.. Respirology. 1998. The pattern of micro-organisms and the efficacy of new macrolide in acute lower respiratory tract infections. doi:10.1111/j.1440-1843.1998.tb00108.x PubMed
[16] K P Völkl et al.. Fortschr Med. 1992. [Therapy of respiratory tract diseases with N-acetylcysteine. An open therapeutic observation study of 2,512 patients]. PubMed
[17] H H Gerards et al.. Fortschr Med. 1991. [Therapy of bronchitis. Successful single-dosage treatment with N-acetylcysteine, results of an administration surveillance study in 3,076 patients]. PubMed

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