Pelargonium sidoides untuk Acute Bronchitis

Meta-analyses demonstrate Pelargonium sidoides (EPs 7630) may significantly reduce bronchitis symptom severity and working inability. Approved as a medicine for respiratory infections in multiple countries. RCT showed working inability decreased to 16% vs 43% in placebo group after 7 days.

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Kesimpulan

Key Study Findings

Other

Research Landscape and Emerging Trends in Herbal Medicine for Pediatric Respiratory Tract Infections: A CiteSpace-Based …

Dose: None vs: None Outcome: research landscape of herbal medicine for pediatric RTIs Efek: None None

Populasi: pediatric patients with respiratory tract infections

Systematic Review

Pelargonium sidoides - from ethnopharmacology to evidence-based medicine: a systematic review.

Dose: None vs: None Outcome: clinical efficacy of Pelargonium sidoides for respiratory tract … Efek: None None

Populasi: patients with acute bronchitis, rhinosinusitis, and tonsillopharyngitis

Randomized Controlled Trial n=240 1 weeks Double-blind

Efficacy and Safety of YJP-40 in Patients with Acute Bronchitis: A Randomized, Double-Blind, Parallel Group …

Dose: None vs: Umckamin syrup (P. sidoides extract alone) Outcome: Change in bronchitis severity score (BSS) at day … Efek: BSS change: -4.31 vs -4.36 non-inferiority demonstrated

Populasi: Patients with acute bronchitis from 7 hospitals

Randomized Controlled Trial 1 weeks Double-blind

Efficacy and safety of mixture of ivy leaf extract and coptidis rhizome in the treatment …

Dose: Ivy leaf extract + Coptidis rhizome vs: Pelargonium sidoides extract Outcome: Bronchitis severity score (BSS) Efek: None None

Populasi: Adults with acute bronchitis

Review

Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases …

Dose: None vs: None Outcome: inflammation markers Efek: None None

Populasi: Covid-19

Randomized Controlled Trial n=591 1.0 weeks Open-label

Safety of Pelargonium extract EPs 7630 in young children with acute bronchitis.

Dose: 7.2% vs: None Outcome: None Efek: None None

Populasi: Ab received eps 7630 syrup or solution for 7 days

Key Statistics

Studi

2000

Peserta

↑

Positive

Peringkat

Referenced Papers

Research Landscape and Emerging Trends in Herbal Medicine for Pediatric Respiratory Tract Infections: A CiteSpace-Based Bibliometric Analysis. Other

Health science reports 2026

Pelargonium sidoides - from ethnopharmacology to evidence-based medicine: a systematic review. Systematic Review

Phytomedicine : international … 2026

Efficacy and Safety of YJP-40 in Patients with Acute Bronchitis: A Randomized, Double-Blind, Parallel Group Study. Other

Tuberculosis and respiratory … 2025

Efficacy and safety of mixture of ivy leaf extract and coptidis rhizome in the treatment of acute bronchitis: multicenter, randomized, … RCT

Current medical research … 2024 2 sitasi

Safety of Pelargonium extract EPs 7630 in young children with acute bronchitis. Other

Frontiers in pediatrics 2023 7 sitasi

Effects of EPs 7630 on the duration of inability to work in acute bronchitis - a meta-analysis. Other

Multidisciplinary respiratory medicine 2023 4 sitasi

Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach. Review

Advances in experimental … 2023 2 sitasi

Chemical characterisation of Pelargonium sidoides root based on LC-QToF-MS non-target screening strategies. Other

Phytochemical analysis : … 2022 14 sitasi

Effects of Pelargonium sidoides extract EPs 7630 on acute cough and quality of life - a meta-analysis of randomized, placebo-controlled … Other

Multidisciplinary respiratory medicine 2022 13 sitasi

The efficacy and safety of DW1601 in patients with acute bronchitis: a multi-center, randomized, double-blind, phase III clinical trial. RCT

The Korean journal … 2022 3 sitasi

Pelargonium sidoides root extract for the treatment of acute cough due to lower respiratory tract infection in adults: a feasibility … RCT

BMC complementary medicine … 2021 16 sitasi

Complementary and alternative medicine in the treatment of acute bronchitis in children: A systematic review. Systematic Review

Complementary therapies in … 2020 36 sitasi

Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells. Other

PloS one 2019 50 sitasi

Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections. Meta-Analysis

BMC pediatrics 2019 27 sitasi

Treatment with EPs 7630, a Pelargonium Sidoides Root Extract, Is Effective and Safe in Patients with the Common Cold: Results … Other

Integrative medicine (Encinitas, … 2019 17 sitasi

HATRIC: a study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for the treatment of acute cough due to lower respiratory … Other

Pilot and feasibility … 2019 8 sitasi

Pelargonium sidoides extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in … Review

International journal of … 2018 55 sitasi

EPs 7630 is effective and safe in children under 6 years with acute respiratory tract infections: clinical studies revisited. Review

Current medical research … 2018 28 sitasi

Evaluation of pharmacodynamic activities of EPs® 7630, a special extract from roots of Pelargonium sidoides, in animals models of cough, … Other

Phytomedicine : international … 2015 35 sitasi

Reproduction of the Medicinal Plant Pelargonium sidoides via Somatic Embryogenesis. Other

Planta medica 2015 9 sitasi

Pelargonium sidoides extract for treating acute respiratory tract infections. Meta-Analysis

The Cochrane database … 2013 125 sitasi

Positioning of the Bronchitis Severity Score (BSS) for standardised use in clinical studies. Review

Current medical research … 2013 25 sitasi

EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo. Other

Antiviral research 2012 107 sitasi

Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents. RCT

Pediatrics international : … 2012 56 sitasi

Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvement. Other

Annals of hepatology 2012

African Geranium (EPs 7630), part 2: the efficacy of Pelargonium sidoides (EPs 7630) in the treatment of acute bronchitis in … Other

Holistic nursing practice 2012

Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel … Other

Phytomedicine : international … 2011 139 sitasi

Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis - a randomized, double-blind, placebo-controlled multicenter trial … RCT

International journal of … 2010 64 sitasi

Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitis. RCT

Acta paediatrica (Oslo, … 2010 63 sitasi

Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a … RCT

Current medical research … 2010 54 sitasi

[Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment]. RCT

Wiener medizinische Wochenschrift … 2010 6 sitasi

A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae). Review

Journal of ethnopharmacology 2008 165 sitasi

Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Meta-Analysis

Phytomedicine : international … 2008 100 sitasi

Pelargonium sidoides extract for acute respiratory tract infections. Systematic Review

The Cochrane database … 2008 71 sitasi

EPs 7630 improves acute bronchitic symptoms and shortens time to remission. Results of a randomised, double-blind, placebo-controlled, multicentre trial. RCT

Planta medica 2008 40 sitasi

Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre … RCT

Current medical research … 2007 81 sitasi

Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children. Other

Phytomedicine : international … 2007 71 sitasi

EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. Other

Phytomedicine : international … 2007 54 sitasi

EPs 7630-solution--an effective therapeutic option in acute and exacerbating bronchitis. Other

Phytomedicine : international … 2007 39 sitasi

[Pelargonium sidoides-extract (EPs 7630): registration confirms efficacy and safety]. Review

Wiener medizinische Wochenschrift … 2007 23 sitasi

Liquid herbal drug preparation from the root of Pelargonium sidoides is effective against acute bronchitis: results of a double-blind study … RCT

Phytomedicine : international … 2007 12 sitasi

Treatment of acute bronchitis in adults with a pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo-controlled trial. RCT

Explore (New York, … 2005 100 sitasi

Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled … RCT

Phytomedicine : international … 2003 104 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 30 drops (1.5 mL) liquid extract 3x/day or 20 mg EPs 7630 tablets 3x/day
duration:: 7-14 days

Batas atas: No established UL

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	--
None	--	Positive	--
None	1 weeks	Neutral	240
Ivy leaf extract + Coptidis rhizome	1 weeks	Positive	--
None	--	Mixed	--
7.2%	1.0 weeks	Positive	591
83.6%	10.4 weeks	Mixed	505
None	--	Positive	2195

Waktu terbaik diminum: At onset of respiratory symptoms; 3x daily for up to 14 days

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Gastrointestinal discomfort (rare)
⚠ Allergic skin reactions (rare)
⚠ Nosebleeds (rare)
⚠ Hepatotoxicity (very rare, case reports)

Interaksi yang Diketahui

● Anticoagulants (theoretical increased bleeding risk due to coumarin content)
● Immunosuppressant medications (may modulate immune function)

Asupan atas yang dapat ditoleransi: No established UL

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Frequently Asked Questions

Does Pelargonium sidoides help with Acute Bronchitis?

Based on 8 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Pelargonium sidoides may support Acute Bronchitis management. Our evidence grade is A (Strong Evidence).

How much Pelargonium sidoides should I take for Acute Bronchitis?

Studies have used various dosages. A commonly studied range is 30 drops (1.5 mL) liquid extract 3x/day or 20 mg EPs 7630 tablets 3x/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Pelargonium sidoides?

Reported side effects may include Gastrointestinal discomfort (rare), Allergic skin reactions (rare), Nosebleeds (rare), Hepatotoxicity (very rare, case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Pelargonium sidoides and Acute Bronchitis?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Acute Bronchitis

N-Acetylcysteine B

Kesimpulan Singkat

Evidence Strength92%

High confidence

Rincian Studi

RCT (13)Meta (3)Other (0)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Acute Bronchitis

Pelajari Lebih Lanjut

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