Pelargonium sidoides ： Acute Bronchitis
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。Meta-analyses demonstrate Pelargonium sidoides (EPs 7630) may significantly reduce bronchitis symptom severity and working inability. Approved as a medicine for respiratory infections in multiple countries. RCT showed working inability decreased to 16% vs 43% in placebo group after 7 days.
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A
結論
Meta-analyses demonstrate Pelargonium sidoides (EPs 7630) may significantly reduce bronchitis symptom severity and working inability. Approved as a medicine for respiratory infections in multiple countries. RCT showed working inability decreased to 16% vs 43% in placebo group after 7 days.
Key Study Findings
Other
Research Landscape and Emerging Trends in Herbal Medicine for Pediatric Respiratory Tract Infections: A CiteSpace-Based …
Dose: None
vs: None
Outcome: research landscape of herbal medicine for pediatric RTIs
効果: None
None
対象集団: pediatric patients with respiratory tract infections
Systematic Review
Pelargonium sidoides - from ethnopharmacology to evidence-based medicine: a systematic review.
Dose: None
vs: None
Outcome: clinical efficacy of Pelargonium sidoides for respiratory tract …
効果: None
None
対象集団: patients with acute bronchitis, rhinosinusitis, and tonsillopharyngitis
Randomized Controlled Trial
n=240
1 weeks
Double-blind
Efficacy and Safety of YJP-40 in Patients with Acute Bronchitis: A Randomized, Double-Blind, Parallel Group …
Dose: None
vs: Umckamin syrup (P. sidoides extract alone)
Outcome: Change in bronchitis severity score (BSS) at day …
効果: BSS change: -4.31 vs -4.36
non-inferiority demonstrated
対象集団: Patients with acute bronchitis from 7 hospitals
Randomized Controlled Trial
1 weeks
Double-blind
Efficacy and safety of mixture of ivy leaf extract and coptidis rhizome in the treatment …
Dose: Ivy leaf extract + Coptidis rhizome
vs: Pelargonium sidoides extract
Outcome: Bronchitis severity score (BSS)
効果: None
None
対象集団: Adults with acute bronchitis
Review
Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases …
Dose: None
vs: None
Outcome: inflammation markers
効果: None
None
対象集団: Covid-19
Randomized Controlled Trial
n=591
1.0 weeks
Open-label
Safety of Pelargonium extract EPs 7630 in young children with acute bronchitis.
Dose: 7.2%
vs: None
Outcome: None
効果: None
None
対象集団: Ab received eps 7630 syrup or solution for 7 days
Key Statistics
8
研究数
2000
参加者数
↑
Positive
A
グレード
Referenced Papers
Health science reports
2026
Pelargonium sidoides - from ethnopharmacology to evidence-based medicine: a systematic review.
Systematic Review
Phytomedicine : international …
2026
Tuberculosis and respiratory …
2025
Current medical research …
2024
2 件の引用
Frontiers in pediatrics
2023
7 件の引用
Effects of EPs 7630 on the duration of inability to work in acute bronchitis - a meta-analysis.
Other
Multidisciplinary respiratory medicine
2023
4 件の引用
Advances in experimental …
2023
2 件の引用
Phytochemical analysis : …
2022
14 件の引用
Multidisciplinary respiratory medicine
2022
13 件の引用
The Korean journal …
2022
3 件の引用
BMC complementary medicine …
2021
16 件の引用
Complementary and alternative medicine in the treatment of acute bronchitis in children: A systematic review.
Systematic Review
Complementary therapies in …
2020
36 件の引用
PloS one
2019
50 件の引用
Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections.
Meta-Analysis
BMC pediatrics
2019
27 件の引用
Integrative medicine (Encinitas, …
2019
17 件の引用
Pilot and feasibility …
2019
8 件の引用
International journal of …
2018
55 件の引用
Current medical research …
2018
28 件の引用
Phytomedicine : international …
2015
35 件の引用
Planta medica
2015
9 件の引用
The Cochrane database …
2013
125 件の引用
Current medical research …
2013
25 件の引用
Antiviral research
2012
107 件の引用
Pediatrics international : …
2012
56 件の引用
Annals of hepatology
2012
Holistic nursing practice
2012
Phytomedicine : international …
2011
139 件の引用
International journal of …
2010
64 件の引用
Acta paediatrica (Oslo, …
2010
63 件の引用
Current medical research …
2010
54 件の引用
Wiener medizinische Wochenschrift …
2010
6 件の引用
Journal of ethnopharmacology
2008
165 件の引用
Phytomedicine : international …
2008
100 件の引用
Pelargonium sidoides extract for acute respiratory tract infections.
Systematic Review
The Cochrane database …
2008
71 件の引用
Planta medica
2008
40 件の引用
Current medical research …
2007
81 件の引用
Phytomedicine : international …
2007
71 件の引用
Phytomedicine : international …
2007
54 件の引用
Phytomedicine : international …
2007
39 件の引用
Wiener medizinische Wochenschrift …
2007
23 件の引用
Phytomedicine : international …
2007
12 件の引用
Explore (New York, …
2005
100 件の引用
Phytomedicine : international …
2003
104 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 30 drops (1.5 mL) liquid extract 3x/day or 20 mg EPs 7630 tablets 3x/day
- duration:
- 7-14 days
上限量： No established UL
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 1 weeks | Neutral | 240 |
| Ivy leaf extract + Coptidis rhizome | 1 weeks | Positive | -- |
| None | -- | Mixed | -- |
| 7.2% | 1.0 weeks | Positive | 591 |
| 83.6% | 10.4 weeks | Mixed | 505 |
| None | -- | Positive | 2195 |
推奨摂取タイミング： At onset of respiratory symptoms; 3x daily for up to 14 days
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (rare)
- ⚠ Allergic skin reactions (rare)
- ⚠ Nosebleeds (rare)
- ⚠ Hepatotoxicity (very rare, case reports)
既知の相互作用
- ● Anticoagulants (theoretical increased bleeding risk due to coumarin content)
- ● Immunosuppressant medications (may modulate immune function)
耐容上限摂取量： No established UL
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Pelargonium sidoides help with Acute Bronchitis?
Based on 8 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Pelargonium sidoides may support Acute Bronchitis management. Our evidence grade is A (Strong Evidence).
How much Pelargonium sidoides should I take for Acute Bronchitis?
Studies have used various dosages. A commonly studied range is 30 drops (1.5 mL) liquid extract 3x/day or 20 mg EPs 7630 tablets 3x/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Pelargonium sidoides?
Reported side effects may include Gastrointestinal discomfort (rare), Allergic skin reactions (rare), Nosebleeds (rare), Hepatotoxicity (very rare, case reports). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Pelargonium sidoides and Acute Bronchitis?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Acute Bronchitis
References
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- [2] Oksana Honchar et al.. Phytomedicine. 2026. Pelargonium sidoides - from ethnopharmacology to evidence-based medicine: a systematic review. doi:10.1016/j.phymed.2026.157880 PubMed
- [3] Chin Kook Rhee. Tuberc Respir Dis (Seoul). 2025. Efficacy and Safety of YJP-40 in Patients with Acute Bronchitis: A Randomized, Double-Blind, Parallel Group Study. doi:10.4046/trd.2024.0177 PubMed
- [4] Kyung-Il Han et al.. Curr Med Res Opin. 2024. Efficacy and safety of mixture of ivy leaf extract and coptidis rhizome in the treatment of acute bronchitis: multicenter, randomized, … doi:10.1080/03007995.2024.2362273 PubMed
- [5] Wolfgang Kamin et al.. Front Pediatr. 2023. Safety of Pelargonium extract EPs 7630 in young children with acute bronchitis. doi:10.3389/fped.2023.1107984 PubMed
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- [7] Neda Taner et al.. Adv Exp Med Biol. 2023. Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach. doi:10.1007/978-3-031-28012-2_23 PubMed
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- [13] Michael Roth et al.. PLoS One. 2019. Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells. doi:10.1371/journal.pone.0210702 PubMed
- [14] Georg Seifert et al.. BMC Pediatr. 2019. Faster recovery and reduced paracetamol use - a meta-analysis of EPs 7630 in children with acute respiratory tract infections. doi:10.1186/s12887-019-1473-z PubMed
- [15] David S Riley et al.. Integr Med (Encinitas). 2019. Treatment with EPs 7630, a Pelargonium Sidoides Root Extract, Is Effective and Safe in Patients with the Common Cold: Results … PubMed
- [16] Amy Whitehead et al.. Pilot Feasibility Stud. 2019. HATRIC: a study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for the treatment of acute cough due to lower respiratory … doi:10.1186/s40814-019-0478-6 PubMed
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- [23] Linda L Theisen et al.. Antiviral Res. 2012. EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo. doi:10.1016/j.antiviral.2012.03.006 PubMed
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- [25] Rolf Teschke et al.. Ann Hepatol. 2012. Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvement. PubMed
- [26] Stephanie Maxine Ross. Holist Nurs Pract. 2012. African Geranium (EPs 7630), part 2: the efficacy of Pelargonium sidoides (EPs 7630) in the treatment of acute bronchitis in … doi:10.1097/HNP.0b013e3182650c18 PubMed
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- [33] Taofikat B Agbabiaka et al.. Phytomedicine. 2008. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. doi:10.1016/j.phymed.2007.11.023 PubMed
- [34] Antje Timmer et al.. Cochrane Database Syst Rev. 2008. Pelargonium sidoides extract for acute respiratory tract infections. doi:10.1002/14651858.CD006323.pub2 PubMed
- [35] Heinrich Matthys et al.. Planta Med. 2008. EPs 7630 improves acute bronchitic symptoms and shortens time to remission. Results of a randomised, double-blind, placebo-controlled, multicentre trial. doi:10.1055/s-2008-1074519 PubMed
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- [38] W Beil et al.. Phytomedicine. 2007. EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. doi:10.1016/j.phymed.2006.11.024 PubMed
- [39] H Matthys et al.. Phytomedicine. 2007. EPs 7630-solution--an effective therapeutic option in acute and exacerbating bronchitis. doi:10.1016/j.phymed.2006.11.017 PubMed
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