Glutathione için Post-Viral Fatigue
D Araştırma Yalnızca ön araştırmalar mevcuttur (laboratuvar çalışmaları, olgu raporları).Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.
Sonuç
Intracellular glutathione depletion is observed in chronic illness and post-viral states. Liposomal glutathione forms show better bioavailability than standard oral supplements. Direct supplementation studies for post-viral fatigue are still in early stages.
Key Study Findings
Popülasyon: Pacific white shrimp (L. vannamei) at high stocking density
Popülasyon: Aged C57BL/6J mice (73 weeks old)
Popülasyon: Unfit adult thoroughbred geldings (6.7+/-1.6 yr)
Popülasyon: ME/CFS (n=27) and Long COVID (n=20) vs healthy controls
Popülasyon: CFS patients (106, 2021-2023)
Popülasyon: 16 healthy, 15 ME/CFS, 15 Long COVID donors
Key Statistics
3
Çalışmalar
100
Katılımcılar
Positive
Derece
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Yaygın Kullanılan Dozajlar
- general:
- 250-500 mg/day
- immunesupport:
- 500-1,000 mg/day (liposomal preferred)
Üst sınır: No established UL
Araştırmalarda İncelenen Dozajlar
| Dozaj | Süre | Etki | N |
|---|---|---|---|
| 0.2% supplementation | 8 weeks | Positive | 270 |
| 400 mg/kg/day | 8 weeks | Positive | -- |
| 21 g/day for 30 days | 4 weeks | Positive | 10 |
| None | -- | Positive | 72 |
| Qiye Shen'an Pian + glutathione + vitamin B1 | -- | Positive | 106 |
| None | -- | Negative | 46 |
| 34 g | -- | Positive | -- |
| SELENOP autoantibodies (measured) | -- | Positive | -- |
En iyi alım zamanı: On empty stomach; liposomal forms have superior absorption
Safety & Side Effects
Bildirilen Yan Etkiler
- ⚠ Generally well tolerated
- ⚠ Bloating and cramping (oral form)
- ⚠ Allergic reactions (rare)
- ⚠ Zinc depletion with chronic high-dose use (theoretical)
Bilinen Etkileşimler
- ● Chemotherapy agents (may modify oxidative mechanisms; consult oncologist)
- ● Nitroglycerin (may enhance hypotensive effects)
Tolere edilebilir üst alım: No established UL
Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
Frequently Asked Questions
Does Glutathione help with Post-Viral Fatigue?
How much Glutathione should I take for Post-Viral Fatigue?
Are there side effects of Glutathione?
How strong is the evidence for Glutathione and Post-Viral Fatigue?
Related Evidence
Şu durum için diğer içerikler: Post-Viral Fatigue
References
- [1] Vishnu Shankar et al.. Proc Natl Acad Sci U S A. 2025. Oxidative stress is a shared characteristic of ME/CFS and Long COVID. doi:10.1073/pnas.2426564122 PubMed
- [2] Shafaq Fatima. PLoS One. 2025. N-acetyl-L-cysteine and lauric acid; effective antioxidant and antimicrobial feed additives for juvenile Pacific white shrimp (Litopenaeus vannamei) cultured at high … doi:10.1371/journal.pone.0315819 PubMed
- [3] Madison R Barshick et al.. Animals (Basel). 2025. Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. doi:10.3390/ani15020215 PubMed
- [4] Duo Zhang et al.. Antioxidants (Basel). 2025. Protective Effect of Methyl Sulfonyl Methane on the Progression of Age-Induced Bone Loss by Regulating Oxidative Stress-Mediated Bone Resorption. doi:10.3390/antiox14020216 PubMed
- [5] Vishnu Shankar et al.. bioRxiv. 2024. Oxidative Stress is a shared characteristic of ME/CFS and Long COVID. doi:10.1101/2024.05.04.592477 PubMed
- [6] Jingxin Ouyang et al.. Poult Sci. 2024. Dietary vitamin B6 supplementation alleviates heat stress-induced intestinal barrier impairment by regulating the gut microbiota and metabolites in broilers. doi:10.1016/j.psj.2024.104202 PubMed
- [7] Jun Liu et al.. Altern Ther Health Med. 2024. Effects of Qiye Shen'an Pian Combined with Glutamate and Vitamin B1 on Fatigue State, Immune Function and Quality of Life … PubMed
- [8] Qian Sun et al.. Redox Biol. 2023. Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone. doi:10.1016/j.redox.2023.102796 PubMed
- [9] Xiaoyao Miao et al.. Biomed Chromatogr. 2022. Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome. doi:10.1002/bmc.5379 PubMed
- [10] Leonard A Jason et al.. Mol Omics. 2022. Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious … doi:10.1039/d2mo00124a PubMed
- [11] Beata R Godlewska et al.. Psychopharmacology (Berl). 2022. Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla. doi:10.1007/s00213-021-05986-6 PubMed
- [12] Andrew McCaddon et al.. Med Hypotheses. 2021. COVID-19: A methyl-group assault? doi:10.1016/j.mehy.2021.110543 PubMed
- [13] Da-Ae Kwon et al.. Pharm Biol. 2021. Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora. doi:10.1080/13880209.2021.1900878 PubMed
- [14] Yan-Hui Li et al.. Zhen Ci Yan Jiu. 2021. [Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome]. doi:10.13702/j.1000-0607.200998 PubMed
- [15] Robert Naclerio et al.. World Allergy Organ J. 2020. International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients … doi:10.1016/j.waojou.2020.100106 PubMed
- [16] Sushil K Jain et al.. J Am Coll Nutr. 2020. Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans? doi:10.1080/07315724.2020.1789518 PubMed
- [17] Rajesh Parsanathan et al.. Nutrients. 2020. l-Cysteine and Vitamin D Co-Supplementation Alleviates Markers of Musculoskeletal Disorders in Vitamin D-Deficient High-Fat Diet-Fed Mice. doi:10.3390/nu12113406 PubMed
- [18] Akram Zarbalizadeh-Saed et al.. Biol Trace Elem Res. 2020. Effect of Slow-Release Pellets of Selenium and Iodine on Performance and Some Blood Metabolites of Pregnant Moghani Ewes and Their … doi:10.1007/s12011-019-01853-w PubMed
- [19] Vandana Thakur et al.. Neurotox Res. 2020. Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters. doi:10.1007/s12640-020-00231-y PubMed
- [20] Xue Wang et al.. Oxid Med Cell Longev. 2018. Antifatigue Potential Activity of Sarcodon imbricatus in Acute Excise-Treated and Chronic Fatigue Syndrome in Mice via Regulation of Nrf2-Mediated Oxidative … doi:10.1155/2018/9140896 PubMed
- [21] Hyun-Jung Park et al.. BMC Complement Altern Med. 2018. Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats. doi:10.1186/s12906-018-2193-x PubMed
- [22] Gerwyn Morris et al.. Mol Neurobiol. 2017. Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome. doi:10.1007/s12035-016-9975-2 PubMed
- [23] Benjamin H Natelson et al.. J Neurol Sci. 2017. Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity. doi:10.1016/j.jns.2017.02.046 PubMed
- [24] Kuldeep Sarvaiya et al.. Brain Res Bull. 2016. Investigation of the effects of vanilloids in chronic fatigue syndrome. doi:10.1016/j.brainresbull.2016.09.015 PubMed
- [25] Gerwyn Morris et al.. BMC Med. 2015. The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. doi:10.1186/s12916-015-0310-y PubMed
- [26] Aiping Chi et al.. Carbohydr Polym. 2015. Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats. doi:10.1016/j.carbpol.2014.12.082 PubMed
- [27] Gerwyn Morris et al.. Mol Neurobiol. 2014. The glutathione system: a new drug target in neuroimmune disorders. doi:10.1007/s12035-014-8705-x PubMed
- [28] Mamta Sachdeva Dhingra et al.. Pharmacol Rep. 2014. Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice. doi:10.1016/j.pharep.2014.01.004 PubMed
- [29] Robert E Click. J Immunol Methods. 2014. Review: 2-mercaptoethanol alteration of in vitro immune functions of species other than murine. doi:10.1016/j.jim.2013.11.007 PubMed
- [30] Jia Wang et al.. Arch Pharm Res. 2014. The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome. doi:10.1007/s12272-013-0235-y PubMed
- [31] N Sivaranjani et al.. J Clin Diagn Res. 2013. Role of reactive oxygen species and antioxidants in atopic dermatitis. doi:10.7860/JCDR/2013/6635.3732 PubMed
- [32] Dikoma C Shungu et al.. NMR Biomed. 2012. Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder … doi:10.1002/nbm.2772 PubMed
- [33] D Lackeyram et al.. J Anim Sci. 2012. The in vivo infusion of hydrogen peroxide induces oxidative stress and differentially affects the activities of small intestinal carbohydrate digestive … doi:10.2527/jas.54011 PubMed
- [34] Chang-Zheng Liu et al.. Zhen Ci Yan Jiu. 2012. [Effect of acupuncture on serum malonaldehyde content, superoxide dismutase and glutathione peroxidase activity in chronic fatigue syndrome rats]. PubMed
- [35] Chiara De Luca et al.. Int J Environ Res Public Health. 2011. The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. doi:10.3390/ijerph8072770 PubMed
- [36] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
- [37] Michael Maes et al.. Neuro Endocrinol Lett. 2011. Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway … PubMed
- [38] Amit Gupta et al.. J Neuroimmunol. 2010. Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive … doi:10.1016/j.jneuroim.2010.05.021 PubMed
- [39] Chang-Zheng Liu et al.. Zhongguo Zhen Jiu. 2010. [Effect of Tuina on oxygen free radicals metabolism in patients with chronic fatigue syndrome]. PubMed
- [40] Anil Kumar et al.. Fundam Clin Pharmacol. 2009. Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations. doi:10.1111/j.1472-8206.2008.00638.x PubMed
- [41] Anand Kamal Sachdeva et al.. Behav Brain Res. 2009. Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence. doi:10.1016/j.bbr.2009.07.020 PubMed
- [42] B K Puri et al.. Prostaglandins Leukot Essent Fatty Acids. 2009. An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome). doi:10.1016/j.plefa.2009.10.002 PubMed
- [43] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
- [44] Ross S Richards et al.. Arch Med Res. 2007. Erythrocyte oxidative damage in chronic fatigue syndrome. doi:10.1016/j.arcmed.2006.06.008 PubMed
- [45] Y Jammes et al.. J Intern Med. 2005. Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. doi:10.1111/j.1365-2796.2005.01452.x PubMed
- [46] Anjali Singal et al.. J Med Food. 2005. Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice. doi:10.1089/jmf.2005.8.47 PubMed
- [47] Ravi Kumar Kurup et al.. Int J Neurosci. 2003. Hypothalamic digoxin, cerebral chemical dominance and myalgic encephalomyelitis. doi:10.1080/00207450390200026 PubMed
- [48] Ravi Kumar Kurup et al.. Acta Neuropsychiatr. 2003. Isoprenoid pathway dysfunction in chronic fatigue syndrome. doi:10.1034/j.1601-5215.2003.00045.x PubMed
- [49] Amanpreet Singh et al.. J Med Food. 2002. Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. doi:10.1089/109662002763003366 PubMed
- [50] Amanpreet Singh et al.. Indian J Exp Biol. 2002. Role of antioxidants in chronic fatigue syndrome in mice. PubMed
- [51] A C Bested et al.. Med Hypotheses. 2001. Chronic fatigue syndrome: neurological findings may be related to blood--brain barrier permeability. doi:10.1054/mehy.2001.1306 PubMed
- [52] A C Logan et al.. Altern Med Rev. 2001. Chronic fatigue syndrome: oxidative stress and dietary modifications. PubMed
- [53] S Fulle et al.. Free Radic Biol Med. 2000. Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome. doi:10.1016/s0891-5849(00)00419-6 PubMed
- [54] B Manuel y Keenoy et al.. J Am Coll Nutr. 2000. Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. doi:10.1080/07315724.2000.10718934 PubMed
- [55] R S Richards et al.. Redox Rep. 2000. Free radicals in chronic fatigue syndrome: cause or effect? doi:10.1179/135100000101535519 PubMed
- [56] L C Heap et al.. J R Soc Med. 1999. Vitamin B status in patients with chronic fatigue syndrome. doi:10.1177/014107689909200405 PubMed
- [57] G Bounous et al.. Med Hypotheses. 1999. Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome. doi:10.1054/mehy.1998.0780 PubMed
- [58] W Dröge et al.. FASEB J. 1997. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. doi:10.1096/fasebj.11.13.9367343 PubMed
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