What is the recommended dosage for Lactoferrin?

General: 100-200 mg/day; Immune Support: 200-600 mg/day

What are the side effects of Lactoferrin?

Potential side effects include: Generally very well tolerated, Mild gastrointestinal effects at high doses, Allergic reactions in those with cow's milk allergy, Constipation (rare, due to iron-binding).

What is lactoferrin and how does it relate to immune function?

Lactoferrin is an iron-binding glycoprotein found in milk, saliva, and mucosal secretions. It has been studied for its antimicrobial, anti-inflammatory, and immunomodulatory properties, including its ability to support natural killer cell and neutrophil function.

What dosage of lactoferrin has been used in clinical studies?

Clinical trials have used bovine lactoferrin at doses of 100–600 mg per day. For immune-related outcomes, 200–300 mg per day is a commonly studied range. Study durations vary from 4 weeks to 3 months.

What are the potential side effects of lactoferrin?

Lactoferrin is generally well tolerated. Mild gastrointestinal effects such as bloating or constipation may occur. Individuals with dairy allergies should exercise caution. Lactoferrin may interact with iron supplements by affecting iron absorption.

Lactoferrin

other

Also known as: Bovine Lactoferrin, Apolactoferrin, Lactotransferrin

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About

Lactoferrin is an iron-binding glycoprotein that sequesters iron from pathogens (bacteriostatic), modulates innate and adaptive immune responses, enhances NK cell and neutrophil activity, and supports intestinal immune barrier function. A meta-analysis showed 40-45% reduced odds of respiratory tract infections.

How It Works

Iron-binding glycoprotein that sequesters iron from pathogens (bacteriostatic); modulates innate and adaptive immune responses; enhances NK cell and neutrophil activity; supports intestinal immune barrier function.

Evidence For Conditions

Condition	Grade	Studies	Participants
Recurrent Infections	A	8	2000	View →

Side Effects

Generally very well tolerated
Mild gastrointestinal effects at high doses
Allergic reactions in those with cow's milk allergy
Constipation (rare, due to iron-binding)

Drug & Supplement Interactions

May enhance absorption of certain antibiotics
May interact with iron supplements (iron-binding properties)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Beta-Glucan Bovine Colostrum Spirulina

Quick Facts

Dosage: General: 100-200 mg/day; Immune_Support: 200-600 mg/day
Forms: capsule powder tablet
Natural Sources: Breast milk, Cow's milk, Colostrum
Upper Limit: No established UL; well-tolerated up to 1,200 mg/day
Best Time: On empty stomach

Evidence Summary

Recurrent Infections A

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.