Lactoferrin for Recurrent Infections
AMeta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.
The Bottom Line
Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.
Key Study Findings
Population: Patient with specific granule deficiency
Population: None
Population: In vitro S. aureus cultures
Population: Crohn's disease patients
Population: animal model
Population: general population
Key Statistics
8
Studies
2000
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 100-200 mg/day
- immunesupport:
- 200-600 mg/day
Upper limit: No established UL; well-tolerated up to 1,200 mg/day
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Mixed | 1 |
| 500 mg | 26.0 weeks | Positive | 48 |
| None | -- | Positive | -- |
| None | -- | Negative | -- |
| None | -- | Neutral | -- |
| 25 mg | 52.0 weeks | Mixed | 14 |
| None | -- | Positive | 60 |
| None | 468.0 weeks | Mixed | -- |
Best taken: On empty stomach
Safety & Side Effects
Reported Side Effects
- ⚠ Generally very well tolerated
- ⚠ Mild gastrointestinal effects at high doses
- ⚠ Allergic reactions in those with cow's milk allergy
- ⚠ Constipation (rare, due to iron-binding)
Known Interactions
- ● May enhance absorption of certain antibiotics
- ● May interact with iron supplements (iron-binding properties)
Tolerable upper intake: No established UL; well-tolerated up to 1,200 mg/day
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Lactoferrin help with Recurrent Infections?
How much Lactoferrin should I take for Recurrent Infections?
Are there side effects of Lactoferrin?
How strong is the evidence for Lactoferrin and Recurrent Infections?
Related Evidence
Other ingredients for Recurrent Infections
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.