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ImmuneCited

Lactoferrin para Recurrent Infections

A

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

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A

Conclusão

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

Key Study Findings

Case Reports n=1
Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant.
Dose: None vs: None Outcome: None Efeito: None None

População: Patient with specific granule deficiency

Randomized Controlled Trial n=48 26.0 weeks Double-blind
Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, …
Dose: 500 mg vs: Placebo Outcome: Disease remission Efeito: None None

População: None

In Vitro
Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus.
Dose: None vs: Conventional antibiotics Outcome: Killing efficacy against extra- and intracellular S. aureus Efeito: None None

População: In vitro S. aureus cultures

Observational Study
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.
Dose: None vs: Healthy controls Outcome: Antibacterial peptide levels in Crohn's disease Efeito: Decreased defensin and LL-37 in Crohn's patients None

População: Crohn's disease patients

In Vitro
Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10.
Dose: None vs: None Outcome: immune function Efeito: None None

População: animal model

Other n=14 52.0 weeks
Abnormal nasal glandular secretion in recurrent sinusitis.
Dose: 25 mg vs: baseline Outcome: oxidative stress markers Efeito: or 2 None

População: general population

Key Statistics

8

Estudos

2000

Participantes

Positive

A

Nota

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:
100-200 mg/day
immunesupport:
200-600 mg/day

Limite superior: No established UL; well-tolerated up to 1,200 mg/day

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
None -- Mixed 1
500 mg 26.0 weeks Positive 48
None -- Positive --
None -- Negative --
None -- Neutral --
25 mg 52.0 weeks Mixed 14
None -- Positive 60
None 468.0 weeks Mixed --

Melhor horário: On empty stomach

Safety & Side Effects

Efeitos Colaterais Relatados

  • Generally very well tolerated
  • Mild gastrointestinal effects at high doses
  • Allergic reactions in those with cow's milk allergy
  • Constipation (rare, due to iron-binding)

Interações Conhecidas

  • May enhance absorption of certain antibiotics
  • May interact with iron supplements (iron-binding properties)

Ingestão máxima tolerável: No established UL; well-tolerated up to 1,200 mg/day

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Lactoferrin help with Recurrent Infections?
Based on 8 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Lactoferrin may support Recurrent Infections management. Our evidence grade is A (Strong Evidence).
How much Lactoferrin should I take for Recurrent Infections?
Studies have used various dosages. A commonly studied range is 100-200 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactoferrin?
Reported side effects may include Generally very well tolerated, Mild gastrointestinal effects at high doses, Allergic reactions in those with cow's milk allergy, Constipation (rare, due to iron-binding). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactoferrin and Recurrent Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Recurrent Infections

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.