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Lactoferrin لـ Recurrent Infections

A

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

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الخلاصة

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

Key Study Findings

Case Reports n=1
Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Patient with specific granule deficiency

Randomized Controlled Trial n=48 26.0 weeks Double-blind
Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, …
Dose: 500 mg مقابل: Placebo Outcome: Disease remission التأثير: None None

المجتمع المدروس: None

In Vitro
Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus.
Dose: None مقابل: Conventional antibiotics Outcome: Killing efficacy against extra- and intracellular S. aureus التأثير: None None

المجتمع المدروس: In vitro S. aureus cultures

Observational Study
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.
Dose: None مقابل: Healthy controls Outcome: Antibacterial peptide levels in Crohn's disease التأثير: Decreased defensin and LL-37 in Crohn's patients None

المجتمع المدروس: Crohn's disease patients

In Vitro
Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10.
Dose: None مقابل: None Outcome: immune function التأثير: None None

المجتمع المدروس: animal model

Other n=14 52.0 weeks
Abnormal nasal glandular secretion in recurrent sinusitis.
Dose: 25 mg مقابل: baseline Outcome: oxidative stress markers التأثير: or 2 None

المجتمع المدروس: general population

Key Statistics

8

الدراسات

2000

المشاركون

Positive

A

التقييم

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:
100-200 mg/day
immunesupport:
200-600 mg/day

الحد الأعلى: No established UL; well-tolerated up to 1,200 mg/day

الجرعات المدروسة في الأبحاث

الجرعة المدة التأثير ن
None -- Mixed 1
500 mg 26.0 weeks Positive 48
None -- Positive --
None -- Negative --
None -- Neutral --
25 mg 52.0 weeks Mixed 14
None -- Positive 60
None 468.0 weeks Mixed --

أفضل وقت للتناول: On empty stomach

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

  • Generally very well tolerated
  • Mild gastrointestinal effects at high doses
  • Allergic reactions in those with cow's milk allergy
  • Constipation (rare, due to iron-binding)

التفاعلات المعروفة

  • May enhance absorption of certain antibiotics
  • May interact with iron supplements (iron-binding properties)

الحد الأقصى المسموح به: No established UL; well-tolerated up to 1,200 mg/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Lactoferrin help with Recurrent Infections?
Based on 8 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Lactoferrin may support Recurrent Infections management. Our evidence grade is A (Strong Evidence).
How much Lactoferrin should I take for Recurrent Infections?
Studies have used various dosages. A commonly studied range is 100-200 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactoferrin?
Reported side effects may include Generally very well tolerated, Mild gastrointestinal effects at high doses, Allergic reactions in those with cow's milk allergy, Constipation (rare, due to iron-binding). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactoferrin and Recurrent Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Recurrent Infections

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.