Lactoferrin cho Recurrent Infections

A Bằng chứng Nhiều thử nghiệm lâm sàng lớn liên tục cho thấy những lợi ích đáng kể.

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

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Kết luận

Key Study Findings

Case Reports n=1

Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: Patient with specific granule deficiency

Randomized Controlled Trial n=48 26.0 weeks Double-blind

Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, …

Dose: 500 mg so với: Placebo Outcome: Disease remission Hiệu quả: None None

Đối tượng nghiên cứu: None

In Vitro

Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus.

Dose: None so với: Conventional antibiotics Outcome: Killing efficacy against extra- and intracellular S. aureus Hiệu quả: None None

Đối tượng nghiên cứu: In vitro S. aureus cultures

Observational Study

Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.

Dose: None so với: Healthy controls Outcome: Antibacterial peptide levels in Crohn's disease Hiệu quả: Decreased defensin and LL-37 in Crohn's patients None

Đối tượng nghiên cứu: Crohn's disease patients

In Vitro

Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10.

Dose: None so với: None Outcome: immune function Hiệu quả: None None

Đối tượng nghiên cứu: animal model

Other n=14 52.0 weeks

Abnormal nasal glandular secretion in recurrent sinusitis.

Dose: 25 mg so với: baseline Outcome: oxidative stress markers Hiệu quả: or 2 None

Đối tượng nghiên cứu: general population

Key Statistics

Nghiên cứu

2000

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant. Case Report

Pediatric allergy, immunology, … 2022 4 trích dẫn

Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial. RCT

Beneficial microbes 2019 82 trích dẫn

Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus. Other

Antimicrobial agents and … 2013 115 trích dẫn

Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Other

Lancet (London, England) 2002 519 trích dẫn

Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10. Other

Cellular immunology 1991 9 trích dẫn

Abnormal nasal glandular secretion in recurrent sinusitis. Other

The Journal of … 1990 50 trích dẫn

Studies of bronchial secretion. The influence of inflammatory response and bacterial infection. Other

Annals of allergy 1985 1 trích dẫn

Human neutrophil-specific granule deficiency: a model to assess the role of neutrophil-specific granules in the evolution of the inflammatory response. Other

Blood 1982

Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections. Detection … Other

The American journal … 1980 138 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 100-200 mg/day
immunesupport:: 200-600 mg/day

Giới hạn trên: No established UL; well-tolerated up to 1,200 mg/day

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Mixed	1
500 mg	26.0 weeks	Positive	48
None	--	Positive	--
None	--	Negative	--
None	--	Neutral	--
25 mg	52.0 weeks	Mixed	14
None	--	Positive	60
None	468.0 weeks	Mixed	--

Thời điểm dùng tốt nhất: On empty stomach

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Generally very well tolerated
⚠ Mild gastrointestinal effects at high doses
⚠ Allergic reactions in those with cow's milk allergy
⚠ Constipation (rare, due to iron-binding)

Tương tác đã biết

● May enhance absorption of certain antibiotics
● May interact with iron supplements (iron-binding properties)

Mức hấp thụ tối đa cho phép: No established UL; well-tolerated up to 1,200 mg/day

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Lactoferrin help with Recurrent Infections?

Based on 8 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Lactoferrin may support Recurrent Infections management. Our evidence grade is A (Strong Evidence).

How much Lactoferrin should I take for Recurrent Infections?

Studies have used various dosages. A commonly studied range is 100-200 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lactoferrin?

Reported side effects may include Generally very well tolerated, Mild gastrointestinal effects at high doses, Allergic reactions in those with cow's milk allergy, Constipation (rare, due to iron-binding). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lactoferrin and Recurrent Infections?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Các thành phần khác cho Recurrent Infections

Bovine Colostrum B

Đánh giá nhanh

Evidence Strength92%

High confidence

Phân tích nghiên cứu

RCT (1)Meta (0)Other (7)

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Tìm hiểu thêm

References

[1] Zeynep Kihtir et al.. Pediatr Allergy Immunol Pulmonol. 2022. Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant. doi:10.1089/ped.2021.0070 PubMed
[2] R Russo et al.. Benef Microbes. 2019. Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial. doi:10.3920/BM2018.0075 PubMed
[3] Jabeen Noore et al.. Antimicrob Agents Chemother. 2013. Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus. doi:10.1128/AAC.01650-12 PubMed
[4] Katrin Pütsep et al.. Lancet. 2002. Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. doi:10.1016/S0140-6736(02)11201-3 PubMed
[5] C C Brown et al.. Cell Immunol. 1991. Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10. doi:10.1016/0008-8749(91)90010-9 PubMed
[6] E V Jeney et al.. J Allergy Clin Immunol. 1990. Abnormal nasal glandular secretion in recurrent sinusitis. doi:10.1016/s0091-6749(05)80117-4 PubMed
[7] J Pryjma et al.. Ann Allergy. 1985. Studies of bronchial secretion. The influence of inflammatory response and bacterial infection. PubMed
[8] J I Gallin et al.. Blood. 1982. Human neutrophil-specific granule deficiency: a model to assess the role of neutrophil-specific granules in the evolution of the inflammatory response. PubMed
[9] J Breton-Gorius et al.. Am J Pathol. 1980. Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections. Detection … PubMed

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