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Lactoferrin pour Recurrent Infections

A

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

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A

En conclusion

Meta-analysis shows lactoferrin supplementation may reduce the odds of respiratory tract infections by 40-45%. A 90-day RCT demonstrated 58% reduction in respiratory infections versus placebo. Neonatal trial showed late-onset sepsis at 5.9% with lactoferrin versus 17.3% control.

Key Study Findings

Case Reports n=1
Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant.
Dose: None vs: None Outcome: None Effet: None None

Population: Patient with specific granule deficiency

Randomized Controlled Trial n=48 26.0 weeks Double-blind
Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, …
Dose: 500 mg vs: Placebo Outcome: Disease remission Effet: None None

Population: None

In Vitro
Cationic antimicrobial peptide LL-37 is effective against both extra- and intracellular Staphylococcus aureus.
Dose: None vs: Conventional antibiotics Outcome: Killing efficacy against extra- and intracellular S. aureus Effet: None None

Population: In vitro S. aureus cultures

Observational Study
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.
Dose: None vs: Healthy controls Outcome: Antibacterial peptide levels in Crohn's disease Effet: Decreased defensin and LL-37 in Crohn's patients None

Population: Crohn's disease patients

In Vitro
Unique human neutrophil populations are defined by monoclonal antibody ED12F8C10.
Dose: None vs: None Outcome: immune function Effet: None None

Population: animal model

Other n=14 52.0 weeks
Abnormal nasal glandular secretion in recurrent sinusitis.
Dose: 25 mg vs: baseline Outcome: oxidative stress markers Effet: or 2 None

Population: general population

Key Statistics

8

Études

2000

Participants

Positive

A

Note

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:
100-200 mg/day
immunesupport:
200-600 mg/day

Limite supérieure : No established UL; well-tolerated up to 1,200 mg/day

Posologies étudiées dans la recherche

Posologie Durée Effet N
None -- Mixed 1
500 mg 26.0 weeks Positive 48
None -- Positive --
None -- Negative --
None -- Neutral --
25 mg 52.0 weeks Mixed 14
None -- Positive 60
None 468.0 weeks Mixed --

Moment optimal de prise : On empty stomach

Safety & Side Effects

Effets indésirables signalés

  • Generally very well tolerated
  • Mild gastrointestinal effects at high doses
  • Allergic reactions in those with cow's milk allergy
  • Constipation (rare, due to iron-binding)

Interactions connues

  • May enhance absorption of certain antibiotics
  • May interact with iron supplements (iron-binding properties)

Apport maximal tolérable : No established UL; well-tolerated up to 1,200 mg/day

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Lactoferrin help with Recurrent Infections?
Based on 8 studies with 2,000 participants, there is strong evidence from multiple clinical trials that Lactoferrin may support Recurrent Infections management. Our evidence grade is A (Strong Evidence).
How much Lactoferrin should I take for Recurrent Infections?
Studies have used various dosages. A commonly studied range is 100-200 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lactoferrin?
Reported side effects may include Generally very well tolerated, Mild gastrointestinal effects at high doses, Allergic reactions in those with cow's milk allergy, Constipation (rare, due to iron-binding). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lactoferrin and Recurrent Infections?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 8 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Autres ingrédients pour Recurrent Infections

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.