What is the recommended dosage for Resveratrol?

General: 150-500 mg/day; Immune Support: 250-500 mg/day trans-resveratrol

What are the side effects of Resveratrol?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Headache, Joint pain at very high doses (>2.5 g/day), Kidney issues at extremely high doses (case reports).

What is resveratrol and how does it relate to immune health?

Resveratrol is a polyphenol found in grapes, red wine, and berries. It has been studied for its antioxidant and anti-inflammatory effects, including modulation of NF-kB and SIRT1 pathways that influence immune cell function and inflammatory responses.

What dosage of resveratrol has been studied in clinical trials?

Clinical studies have used resveratrol at doses of 150–2,000 mg per day. For immune and anti-inflammatory outcomes, doses of 250–500 mg per day of trans-resveratrol are commonly studied over periods of 4 to 12 weeks.

What are the potential side effects of resveratrol?

Resveratrol is generally well tolerated at moderate doses. Higher doses may cause gastrointestinal discomfort, nausea, and diarrhea. It may interact with blood thinners and medications metabolized by cytochrome P450 enzymes.

Resveratrol

antioxidant

Also known as: trans-Resveratrol

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About

Resveratrol is a polyphenol that modulates SIRT1 and AMPK signaling pathways, exhibits anti-inflammatory effects by inhibiting NF-kB, enhances macrophage function, and supports regulatory T-cell activity. Human trials show reduction in inflammatory markers, though low oral bioavailability remains a challenge.

How It Works

Modulates SIRT1 and AMPK signaling pathways; inhibits NF-kB; enhances macrophage function and supports regulatory T-cell activity; promotes immune homeostasis.

Evidence For Conditions

Condition	Grade	Studies	Participants
Chronic Inflammation	C	5	300	View →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Headache
Joint pain at very high doses (>2.5 g/day)
Kidney issues at extremely high doses (case reports)

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk)
CYP1A2, CYP3A4 substrates (may inhibit metabolism)
Estrogen-sensitive conditions (weak estrogenic activity)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Astaxanthin Curcumin Glutathione Quercetin

Quick Facts

Dosage: General: 150-500 mg/day; Immune_Support: 250-500 mg/day trans-resveratrol
Forms: capsule softgel powder liquid
Natural Sources: Red grapes, Red wine, Blueberries, Peanuts, Dark chocolate
Upper Limit: No established UL; generally well-tolerated up to 1,500 mg/day
Best Time: With meals

Evidence Summary

Chronic Inflammation C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.