Conjugated Linoleic Acid per Chronic Inflammation

Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.

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In sintesi

Key Study Findings

Review

A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and …

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Review of curcumin derivatives in cancer treatment

Review

Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: review of dietary polyphenols in type 2 diabetes mellitus management

Review

Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects …

Dose: None vs: None Outcome: Musculoskeletal aging and cellular senescence Effetto: None None

Popolazione: Aging adults with musculoskeletal decline (review)

Review

Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes.

Dose: 1% zinc chloride solution vs: None Outcome: Chronic epipharyngitis symptom improvement Effetto: None None

Popolazione: Patients with chronic epipharyngitis (retracted publication)

Systematic Review

Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Review of TCM compounds in autoimmune skin diseases

Other

The omega effect: Harnessing fish oil for health.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: None

Key Statistics

Studi

150

Partecipanti

↔

Mixed

Grado

Referenced Papers

Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. Review

Nutrients 2025 32 citazioni

Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise. Review

International journal of … 2025 5 citazioni

A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and analogs in cancer treatment (Review). Review

International journal of … 2025 2 citazioni

Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases. Systematic Review

Frontiers in immunology 2025 1 citazioni

The omega effect: Harnessing fish oil for health. Other

Atherosclerosis 2025

Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes. Review

JMA journal 2025

Oral Lichen Planus: A Narrative Review Navigating Etiologies, Clinical Manifestations, Diagnostics, and Therapeutic Approaches. Review

Journal of clinical … 2024 29 citazioni

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS-Induced Colitis Mice. Other

Molecular nutrition & … 2024 15 citazioni

Milk Fat Globules: 2024 Updates. Other

Newborn (Clarksville, Md.) 2024 9 citazioni

From Structure to Function: How Prebiotic Diversity Shapes Gut Integrity and Immune Balance. Review

Nutrients 2024 7 citazioni

Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. RCT

Advances in rheumatology … 2024

Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage Polarization in Inflammatory Diseases. Review

Current molecular pharmacology 2023 72 citazioni

Sodium Butyrate Protects Against Intestinal Oxidative Damage and Neuroinflammation in the Prefrontal Cortex of Ulcerative Colitis Mice Model. Other

Immunological investigations 2023 13 citazioni

Maresin1: A multifunctional regulator in inflammatory bone diseases. Review

International immunopharmacology 2023 8 citazioni

Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass. Review

International journal of … 2022 26 citazioni

Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials. Meta-Analysis

Biomolecular concepts 2022 18 citazioni

Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile. Other

Foods (Basel, Switzerland) 2022 9 citazioni

Obesity-Associated Inflammation: Does Curcumin Exert a Beneficial Role? Review

Nutrients 2021 36 citazioni

Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. Other

Frontiers in medicine 2021 6 citazioni

Resveratrol prevents diabetic nephropathy by reducing chronic inflammation and improving the blood glucose memory effect in non-obese diabetic mice. Other

Naunyn-Schmiedeberg's archives of … 2020 37 citazioni

Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis. Other

Toxicology mechanisms and … 2019 33 citazioni

Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. RCT

Prostaglandins, leukotrienes, and … 2018 38 citazioni

MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol. Review

Medicines (Basel, Switzerland) 2018 23 citazioni

Curcumin: An Effective Inhibitor of Interleukin-6. Review

Current pharmaceutical design 2017 168 citazioni

A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model. Other

Lipids 2017 21 citazioni

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. Other

BMC medicine 2015 230 citazioni

Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-κB) gene and blood cell adhesion molecule expression in patients with … RCT

Blood cells, molecules … 2015 53 citazioni

Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes. Other

Lipids 2012 28 citazioni

Individual isomers of conjugated linoleic acid reduce inflammation associated with established collagen-induced arthritis in DBA/1 mice. Other

The Journal of … 2010 32 citazioni

In vitro study of the effect of diesterified alkoxyglycerols with conjugated linoleic acid on adipocyte inflammatory mediators. Other

Lipids in health … 2010 7 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 1.5-3 g/day

Limite massimo: No established UL

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--
1% zinc chloride solution	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
200 mg	5 weeks	Positive	--
None	--	Positive	--

Momento migliore per l'assunzione: With meals

Safety & Side Effects

Effetti collaterali segnalati

⚠ Gastrointestinal discomfort (nausea, diarrhea)
⚠ Fatigue
⚠ May worsen insulin sensitivity in some individuals
⚠ Liver fat accumulation (some formulations)

Interazioni note

● Diabetes medications (may affect insulin sensitivity)
● Anticoagulants (may have additive effects)

Livello di assunzione massimo tollerabile: No established UL

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Conjugated Linoleic Acid help with Chronic Inflammation?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that Conjugated Linoleic Acid may support Chronic Inflammation management. Our evidence grade is D (Very Early Research).

How much Conjugated Linoleic Acid should I take for Chronic Inflammation?

Studies have used various dosages. A commonly studied range is 1.5-3 g/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Conjugated Linoleic Acid?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Conjugated Linoleic Acid and Chronic Inflammation?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

Related Evidence

Altri ingredienti per Chronic Inflammation

Omega-3 Fatty Acids (EPA/DHA) A Curcumin A Resveratrol C Chaga Mushroom D

Verdetto rapido

Evidence Strength30%

Low confidence

Analisi degli studi

RCT (3)Meta (1)Other (0)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Chronic Inflammation

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.