Omega-3 Fatty Acids (EPA/DHA) ： Chronic Inflammation
AThe VITAL trial and multiple randomized controlled trials demonstrate omega-3 fatty acids may help reduce CRP and modulate inflammatory cytokines. DHA showed stronger anti-inflammatory effects than EPA, lowering 4 pro-inflammatory proteins versus 1 in a randomized study.
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A
結論
The VITAL trial and multiple randomized controlled trials demonstrate omega-3 fatty acids may help reduce CRP and modulate inflammatory cytokines. DHA showed stronger anti-inflammatory effects than EPA, lowering 4 pro-inflammatory proteins versus 1 in a randomized study.
Key Study Findings
Review
Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle.
Dose: None
vs: None
Outcome: Immunosenescence and inflammaging modulation
効果: None
None
対象集団: Aging adults (review)
Observational Study
n=21
4 weeks
Single-blind
Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with …
Dose: None
vs: None
Outcome: Associations between omega-3 SPMs and inflammatory markers
効果: None
None
対象集団: Older adults with low-grade chronic inflammation (CRP>2)
Review
The Impact of Flavonoids and Omega-3 in Mitigating Frailty Syndrome to Improve Treatment Outcomes in …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of flavonoids and omega-3 in PAD with frailty
Review
Proresolving Lipid Mediators in the Respiratory System.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches.
Dose: None
vs: None
Outcome: Sarcopenia progression and muscle function
効果: None
None
対象集団: Older adults with sarcopenia (review)
Review
Immunomodulatory Effects of Omega-3 Fatty Acids: Mechanistic Insights and Health Implications.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of omega-3 fatty acids' immunomodulatory effects
Key Statistics
30
研究数
30000
参加者数
↑
Positive
A
グレード
Referenced Papers
Immunomodulatory Effects of Omega-3 Fatty Acids: Mechanistic Insights and Health Implications.
Review
Molecular nutrition & …
2025
44 件の引用
Nutrients
2025
22 件の引用
Annual review of …
2025
13 件の引用
Specialized pro-resolving mediators and autoimmunity: Recent insights and future perspectives.
Review
Autoimmunity reviews
2025
10 件の引用
Nutrients
2025
6 件の引用
Frontiers in immunology
2025
5 件の引用
Prostaglandins & other …
2025
3 件の引用
Lipids in health …
2025
3 件の引用
International journal of …
2025
3 件の引用
Nutrients
2025
2 件の引用
Atherosclerosis
2025
Current obesity reports
2025
The effects of ω-3 fatty acids on inflammatory and oxidative stress markers in patients with Type 2 diabetes mellitus: A …
Meta-Analysis
Prostaglandins & other …
2024
7 件の引用
Prostaglandins, leukotrienes, and …
2024
6 件の引用
Effect of Omega-3 Fatty Acid Supplementation on Periodontal Inflammation and Pocket Depth Reduction.
Other
Journal of pharmacy …
2024
1 件の引用
Advances in rheumatology …
2024
European review for …
2023
67 件の引用
A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation.
Review
Biochemistry and biophysics …
2023
66 件の引用
Cancer metastasis reviews
2023
28 件の引用
Brain, behavior, and …
2023
18 件の引用
Frontiers in nutrition
2023
17 件の引用
International immunopharmacology
2023
8 件の引用
Nutrients
2022
29 件の引用
Toxicology and applied …
2022
20 件の引用
Effect of omega-3 fatty acids on the telomere length: A mini meta-analysis of clinical trials.
Meta-Analysis
Biomolecular concepts
2022
18 件の引用
The American journal …
2022
1 件の引用
American heart journal …
2022
Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other?
Review
Nutrients
2020
50 件の引用
Reproductive medicine and …
2020
11 件の引用
Clinical nutrition (Edinburgh, …
2020
10 件の引用
Redox modulatory protective effects of ω-3 fatty acids rich fish oil against experimental colitis.
Other
Toxicology mechanisms and …
2019
33 件の引用
Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on lipid profile: A systematic review and meta-analysis.
Meta-Analysis
Diabetes & metabolic …
2019
28 件の引用
Journal of renal …
2019
7 件の引用
Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids.
RCT
Prostaglandins, leukotrienes, and …
2018
38 件の引用
Frontiers in immunology
2017
74 件の引用
European journal of …
2016
102 件の引用
International journal of …
2016
56 件の引用
The association of dietary intake and supplementation of specific polyunsaturated fatty acids with inflammation and functional capacity in chronic obstructive …
Systematic Review
International journal of …
2016
20 件の引用
Clinical journal of …
2016
4 件の引用
Allergology international : …
2015
205 件の引用
Prostaglandins & other …
2015
182 件の引用
Blood cells, molecules …
2015
53 件の引用
Prostaglandins & other …
2015
35 件の引用
Journal of Alzheimer's …
2015
8 件の引用
European journal of …
2014
Nutrition research (New …
2013
90 件の引用
Acta medica Indonesiana
2011
37 件の引用
Journal of the …
2010
11 件の引用
Current atherosclerosis reports
2004
464 件の引用
Prevention of strokes.
Review
Current atherosclerosis reports
2001
2 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 250-500 mg combined EPA/DHA/day
- antiinflammatory:
- 1,000-3,000 mg combined EPA/DHA/day
上限量： 3,000 mg/day EPA+DHA (FDA-recognized as safe)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | 4 weeks | Positive | 21 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： With meals
Safety & Side Effects
報告されている副作用
- ⚠ Fishy aftertaste and burping
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Increased bleeding risk at high doses
- ⚠ Potential LDL cholesterol increase at very high doses
既知の相互作用
- ● Anticoagulants and antiplatelet drugs (may increase bleeding risk)
- ● Blood pressure medications (additive blood pressure lowering)
- ● Orlistat (may reduce omega-3 absorption)
- ● Cyclosporine (may modify immunosuppressive effects)
耐容上限摂取量： 3,000 mg/day EPA+DHA (FDA-recognized as safe)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Omega-3 Fatty Acids (EPA/DHA) help with Chronic Inflammation?
Based on 30 studies with 30,000 participants, there is strong evidence from multiple clinical trials that Omega-3 Fatty Acids (EPA/DHA) may support Chronic Inflammation management. Our evidence grade is A (Strong Evidence).
How much Omega-3 Fatty Acids (EPA/DHA) should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 250-500 mg combined EPA/DHA/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
Reported side effects may include Fishy aftertaste and burping, Gastrointestinal discomfort (nausea, diarrhea), Increased bleeding risk at high doses, Potential LDL cholesterol increase at very high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and Chronic Inflammation?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 30 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Chronic Inflammation
Omega-3 Fatty Acids (EPA/DHA) 他の症状・状態について
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