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ImmuneCited

Quercetin для Allergic Rhinitis

C

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

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C

Итог

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

Key Study Findings

Review
Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Observational Study
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics …
Dose: None или: None Outcome: HMOX1 causal relationship with airway diseases Эффект: CRSwNP OR 0.945, AR OR 0.997, AS OR 0.935 p=0.044, p=0.007, p=0.003

Популяция: CRSwNP, allergic rhinitis, asthma (MR analysis)

Review
Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review.
Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Meta-Analysis n=823
Clinical Effects of Polyphenolic Compounds on Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Dose: None или: Placebo or control Outcome: Total nasal symptom scores in allergic rhinitis Эффект: SMD=0.75 0.0001

Популяция: Patients with seasonal or perennial allergic rhinitis

In Vitro
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum …
Dose: None или: None Outcome: Binding affinity to NFKB1, TRAF6, IL5, IL6 Эффект: Predicted IC50 <50 nM None

Популяция: In silico/computational models

Other
Network pharmacology analysis of the Huangqi-Gancao herb pair reveals quercetin as a therapeutics for allergic …
Dose: None или: OVA-induced AR mice without treatment Outcome: Allergic rhinitis symptoms and histopathology Эффект: None None

Популяция: OVA-induced allergic rhinitis mouse model

Key Statistics

5

Исследования

400

Участники

Positive

C

Оценка

Referenced Papers

Pharmaceuticals (Basel, Switzerland) 2024 14 цитирований
Medicines (Basel, Switzerland) 2021 16 цитирований
Allergy, asthma, and … 2020 152 цитирований
Medicines (Basel, Switzerland) 2020 24 цитирований
Evidence-based complementary and … 2018 25 цитирований
Medicines (Basel, Switzerland) 2018 20 цитирований
European archives of … 2017 37 цитирований
Molecules (Basel, Switzerland) 2016 395 цитирований
BMC complementary and … 2016 30 цитирований
In vivo (Athens, … 2016 14 цитирований
Evidence-based complementary and … 2013 33 цитирований
Alternative medicine review … 2000

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
500-1,000 mg/day
immunesupport:
500-1,500 mg/day

Верхний предел: No established UL; GRAS up to 500 mg/day per FDA

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Positive 823
None -- Positive --
None -- Positive --
None -- Positive --
Quertal + antihistamines 12 weeks Positive 100

Лучшее время приёма: With meals (fat-containing meals improve absorption); often paired with vitamin C or bromelain for enhanced bioavailability

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Headache
  • Tingling in extremities
  • Gastrointestinal discomfort
  • Low oral bioavailability (addressed by phytosome formulations)

Известные взаимодействия

  • Cyclosporine (may increase drug levels)
  • Fluoroquinolone antibiotics (may interfere with bacterial target)
  • CYP3A4 and CYP2C8 substrates (may inhibit metabolism)

Допустимый верхний уровень потребления: No established UL; GRAS up to 500 mg/day per FDA

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Quercetin help with Allergic Rhinitis?
Based on 5 studies with 400 participants, there is limited but promising evidence that Quercetin may support Allergic Rhinitis management. Our evidence grade is C (Some Evidence).
How much Quercetin should I take for Allergic Rhinitis?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Headache, Tingling in extremities, Gastrointestinal discomfort, Low oral bioavailability (addressed by phytosome formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and Allergic Rhinitis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Allergic Rhinitis

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.