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ImmuneCited

Quercetin per Allergic Rhinitis

C

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

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C

In sintesi

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

Key Study Findings

Review
Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
Dose: None vs: None Outcome: None Effetto: None None

Popolazione: None

Observational Study
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics …
Dose: None vs: None Outcome: HMOX1 causal relationship with airway diseases Effetto: CRSwNP OR 0.945, AR OR 0.997, AS OR 0.935 p=0.044, p=0.007, p=0.003

Popolazione: CRSwNP, allergic rhinitis, asthma (MR analysis)

Meta-Analysis n=823
Clinical Effects of Polyphenolic Compounds on Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Dose: None vs: Placebo or control Outcome: Total nasal symptom scores in allergic rhinitis Effetto: SMD=0.75 0.0001

Popolazione: Patients with seasonal or perennial allergic rhinitis

In Vitro
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum …
Dose: None vs: None Outcome: Binding affinity to NFKB1, TRAF6, IL5, IL6 Effetto: Predicted IC50 <50 nM None

Popolazione: In silico/computational models

Other
Network pharmacology analysis of the Huangqi-Gancao herb pair reveals quercetin as a therapeutics for allergic …
Dose: None vs: OVA-induced AR mice without treatment Outcome: Allergic rhinitis symptoms and histopathology Effetto: None None

Popolazione: OVA-induced allergic rhinitis mouse model

Key Statistics

5

Studi

400

Partecipanti

Positive

C

Grado

Referenced Papers

Pharmaceuticals (Basel, Switzerland) 2024 14 citazioni
Medicines (Basel, Switzerland) 2021 16 citazioni
Allergy, asthma, and … 2020 152 citazioni
Medicines (Basel, Switzerland) 2020 24 citazioni
Molecules (Basel, Switzerland) 2016 395 citazioni
Evidence-based complementary and … 2013 33 citazioni
Alternative medicine review … 2000

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:
500-1,000 mg/day
immunesupport:
500-1,500 mg/day

Limite massimo: No established UL; GRAS up to 500 mg/day per FDA

Dosaggi studiati nella ricerca

Dosaggio Durata Effetto N
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Positive 823
None -- Positive --
None -- Positive --
None -- Positive --
Quertal + antihistamines 12 weeks Positive 100

Momento migliore per l'assunzione: With meals (fat-containing meals improve absorption); often paired with vitamin C or bromelain for enhanced bioavailability

Safety & Side Effects

Effetti collaterali segnalati

  • Headache
  • Tingling in extremities
  • Gastrointestinal discomfort
  • Low oral bioavailability (addressed by phytosome formulations)

Interazioni note

  • Cyclosporine (may increase drug levels)
  • Fluoroquinolone antibiotics (may interfere with bacterial target)
  • CYP3A4 and CYP2C8 substrates (may inhibit metabolism)

Livello di assunzione massimo tollerabile: No established UL; GRAS up to 500 mg/day per FDA

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Quercetin help with Allergic Rhinitis?
Based on 5 studies with 400 participants, there is limited but promising evidence that Quercetin may support Allergic Rhinitis management. Our evidence grade is C (Some Evidence).
How much Quercetin should I take for Allergic Rhinitis?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Headache, Tingling in extremities, Gastrointestinal discomfort, Low oral bioavailability (addressed by phytosome formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and Allergic Rhinitis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Allergic Rhinitis

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.