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ImmuneCited

Quercetin für Allergic Rhinitis

C

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

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C

Fazit

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

Key Study Findings

Review
Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
Dose: None vs.: None Outcome: None Wirkung: None None

Population: None

Observational Study
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics …
Dose: None vs.: None Outcome: HMOX1 causal relationship with airway diseases Wirkung: CRSwNP OR 0.945, AR OR 0.997, AS OR 0.935 p=0.044, p=0.007, p=0.003

Population: CRSwNP, allergic rhinitis, asthma (MR analysis)

Meta-Analysis n=823
Clinical Effects of Polyphenolic Compounds on Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Dose: None vs.: Placebo or control Outcome: Total nasal symptom scores in allergic rhinitis Wirkung: SMD=0.75 0.0001

Population: Patients with seasonal or perennial allergic rhinitis

In Vitro
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum …
Dose: None vs.: None Outcome: Binding affinity to NFKB1, TRAF6, IL5, IL6 Wirkung: Predicted IC50 <50 nM None

Population: In silico/computational models

Other
Network pharmacology analysis of the Huangqi-Gancao herb pair reveals quercetin as a therapeutics for allergic …
Dose: None vs.: OVA-induced AR mice without treatment Outcome: Allergic rhinitis symptoms and histopathology Wirkung: None None

Population: OVA-induced allergic rhinitis mouse model

Key Statistics

5

Studien

400

Teilnehmer

Positive

C

Bewertung

Referenced Papers

Pharmaceuticals (Basel, Switzerland) 2024 14 Zitierungen
Medicines (Basel, Switzerland) 2021 16 Zitierungen
Allergy, asthma, and … 2020 152 Zitierungen
Medicines (Basel, Switzerland) 2020 24 Zitierungen
Molecules (Basel, Switzerland) 2016 395 Zitierungen
In vivo (Athens, … 2016 14 Zitierungen
Evidence-based complementary and … 2013 33 Zitierungen
Alternative medicine review … 2000

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:
500-1,000 mg/day
immunesupport:
500-1,500 mg/day

Obergrenze: No established UL; GRAS up to 500 mg/day per FDA

In der Forschung untersuchte Dosierungen

Dosierung Dauer Wirkung N
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Positive 823
None -- Positive --
None -- Positive --
None -- Positive --
Quertal + antihistamines 12 weeks Positive 100

Beste Einnahmezeit: With meals (fat-containing meals improve absorption); often paired with vitamin C or bromelain for enhanced bioavailability

Safety & Side Effects

Gemeldete Nebenwirkungen

  • Headache
  • Tingling in extremities
  • Gastrointestinal discomfort
  • Low oral bioavailability (addressed by phytosome formulations)

Bekannte Wechselwirkungen

  • Cyclosporine (may increase drug levels)
  • Fluoroquinolone antibiotics (may interfere with bacterial target)
  • CYP3A4 and CYP2C8 substrates (may inhibit metabolism)

Tolerierbare Höchstaufnahmemenge: No established UL; GRAS up to 500 mg/day per FDA

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Quercetin help with Allergic Rhinitis?
Based on 5 studies with 400 participants, there is limited but promising evidence that Quercetin may support Allergic Rhinitis management. Our evidence grade is C (Some Evidence).
How much Quercetin should I take for Allergic Rhinitis?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Headache, Tingling in extremities, Gastrointestinal discomfort, Low oral bioavailability (addressed by phytosome formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and Allergic Rhinitis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Andere Inhaltsstoffe für Allergic Rhinitis

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