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ImmuneCited

Quercetin Allergic Rhinitis

C

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

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C

結論

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

Key Study Findings

Review
Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Observational Study
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics …
Dose: None vs: None Outcome: HMOX1 causal relationship with airway diseases 効果: CRSwNP OR 0.945, AR OR 0.997, AS OR 0.935 p=0.044, p=0.007, p=0.003

対象集団: CRSwNP, allergic rhinitis, asthma (MR analysis)

Meta-Analysis n=823
Clinical Effects of Polyphenolic Compounds on Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Dose: None vs: Placebo or control Outcome: Total nasal symptom scores in allergic rhinitis 効果: SMD=0.75 0.0001

対象集団: Patients with seasonal or perennial allergic rhinitis

In Vitro
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum …
Dose: None vs: None Outcome: Binding affinity to NFKB1, TRAF6, IL5, IL6 効果: Predicted IC50 <50 nM None

対象集団: In silico/computational models

Other
Network pharmacology analysis of the Huangqi-Gancao herb pair reveals quercetin as a therapeutics for allergic …
Dose: None vs: OVA-induced AR mice without treatment Outcome: Allergic rhinitis symptoms and histopathology 効果: None None

対象集団: OVA-induced allergic rhinitis mouse model

Key Statistics

5

研究数

400

参加者数

Positive

C

グレード

Referenced Papers

Pharmaceuticals (Basel, Switzerland) 2024 14 件の引用
Medicines (Basel, Switzerland) 2021 16 件の引用
Allergy, asthma, and … 2020 152 件の引用
Medicines (Basel, Switzerland) 2020 24 件の引用
Molecules (Basel, Switzerland) 2016 395 件の引用
In vivo (Athens, … 2016 14 件の引用
Evidence-based complementary and … 2013 33 件の引用
Alternative medicine review … 2000

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:
500-1,000 mg/day
immunesupport:
500-1,500 mg/day

上限量: No established UL; GRAS up to 500 mg/day per FDA

研究で検討された用量

用量 期間 効果 N
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Positive 823
None -- Positive --
None -- Positive --
None -- Positive --
Quertal + antihistamines 12 weeks Positive 100

推奨摂取タイミング: With meals (fat-containing meals improve absorption); often paired with vitamin C or bromelain for enhanced bioavailability

Safety & Side Effects

報告されている副作用

  • Headache
  • Tingling in extremities
  • Gastrointestinal discomfort
  • Low oral bioavailability (addressed by phytosome formulations)

既知の相互作用

  • Cyclosporine (may increase drug levels)
  • Fluoroquinolone antibiotics (may interfere with bacterial target)
  • CYP3A4 and CYP2C8 substrates (may inhibit metabolism)

耐容上限摂取量: No established UL; GRAS up to 500 mg/day per FDA

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Quercetin help with Allergic Rhinitis?
Based on 5 studies with 400 participants, there is limited but promising evidence that Quercetin may support Allergic Rhinitis management. Our evidence grade is C (Some Evidence).
How much Quercetin should I take for Allergic Rhinitis?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Headache, Tingling in extremities, Gastrointestinal discomfort, Low oral bioavailability (addressed by phytosome formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and Allergic Rhinitis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分: Allergic Rhinitis

FDAに関する免責事項: これらの記述は米国食品医薬品局(FDA)による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。