Quercetin ： Allergic Rhinitis
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.
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C
結論
Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.
Key Study Findings
Review
Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Observational Study
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics …
Dose: None
vs: None
Outcome: HMOX1 causal relationship with airway diseases
効果: CRSwNP OR 0.945, AR OR 0.997, AS OR 0.935
p=0.044, p=0.007, p=0.003
対象集団: CRSwNP, allergic rhinitis, asthma (MR analysis)
Review
Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Meta-Analysis
n=823
Clinical Effects of Polyphenolic Compounds on Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Dose: None
vs: Placebo or control
Outcome: Total nasal symptom scores in allergic rhinitis
効果: SMD=0.75
0.0001
対象集団: Patients with seasonal or perennial allergic rhinitis
In Vitro
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum …
Dose: None
vs: None
Outcome: Binding affinity to NFKB1, TRAF6, IL5, IL6
効果: Predicted IC50 <50 nM
None
対象集団: In silico/computational models
Other
Network pharmacology analysis of the Huangqi-Gancao herb pair reveals quercetin as a therapeutics for allergic …
Dose: None
vs: OVA-induced AR mice without treatment
Outcome: Allergic rhinitis symptoms and histopathology
効果: None
None
対象集団: OVA-induced allergic rhinitis mouse model
Key Statistics
5
研究数
400
参加者数
↑
Positive
C
グレード
Referenced Papers
Nutrients
2025
9 件の引用
Respiratory research
2025
9 件の引用
Computers in biology …
2025
8 件の引用
Journal of clinical …
2025
7 件の引用
Naunyn-Schmiedeberg's archives of …
2025
3 件の引用
Clinical Effects of Polyphenolic Compounds on Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Meta-Analysis
The journal of …
2025
2 件の引用
Current computer-aided drug …
2025
2 件の引用
Minerva pediatrics
2025
1 件の引用
Nutrients
2025
Quercetin exhibits multi-target anti-allergic effects in animal models: a systematic review and meta-analysis of preclinical studies.
Systematic Review
Frontiers in pharmacology
2025
Medicine
2025
Current pharmaceutical design
2025
Scientific reports
2025
Scientific reports
2024
26 件の引用
Pharmaceuticals (Basel, Switzerland)
2024
14 件の引用
Acta pharmaceutica (Zagreb, …
2024
1 件の引用
Autoimmunity
2023
70 件の引用
Nutrients
2023
42 件の引用
Cells
2023
13 件の引用
Medicines (Basel, Switzerland)
2023
7 件の引用
Journal of ethnopharmacology
2022
21 件の引用
Asian Pacific journal …
2022
12 件の引用
Immunopharmacology and immunotoxicology
2022
9 件の引用
Evidence-based complementary and …
2022
7 件の引用
BioMed research international
2022
5 件の引用
Medicines (Basel, Switzerland)
2021
16 件の引用
Phytomedicine plus : …
2021
7 件の引用
Allergy, asthma, and …
2020
152 件の引用
Medicines (Basel, Switzerland)
2020
24 件の引用
Evidence-based complementary and …
2020
17 件の引用
Italian journal of …
2019
26 件の引用
Suppressive Effect of Quercetin on Nitric Oxide Production from Nasal Epithelial Cells In Vitro.
Other
Evidence-based complementary and …
2018
25 件の引用
Medicines (Basel, Switzerland)
2018
20 件の引用
European archives of …
2017
37 件の引用
Molecules (Basel, Switzerland)
2016
395 件の引用
BMC complementary and …
2016
30 件の引用
In vivo (Athens, …
2016
14 件の引用
The Journal of …
2015
21 件の引用
Acta bio-medica : …
2015
12 件の引用
Evidence-based complementary and …
2013
33 件の引用
International immunopharmacology
2013
31 件の引用
The Journal of …
2009
220 件の引用
Phytomedicine : international …
2004
55 件の引用
Primary care
2002
56 件の引用
Alternative medicine review …
2000
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-1,000 mg/day
- immunesupport:
- 500-1,500 mg/day
上限量： No established UL; GRAS up to 500 mg/day per FDA
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 823 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| Quertal + antihistamines | 12 weeks | Positive | 100 |
推奨摂取タイミング： With meals (fat-containing meals improve absorption); often paired with vitamin C or bromelain for enhanced bioavailability
Safety & Side Effects
報告されている副作用
- ⚠ Headache
- ⚠ Tingling in extremities
- ⚠ Gastrointestinal discomfort
- ⚠ Low oral bioavailability (addressed by phytosome formulations)
既知の相互作用
- ● Cyclosporine (may increase drug levels)
- ● Fluoroquinolone antibiotics (may interfere with bacterial target)
- ● CYP3A4 and CYP2C8 substrates (may inhibit metabolism)
耐容上限摂取量： No established UL; GRAS up to 500 mg/day per FDA
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Quercetin help with Allergic Rhinitis?
Based on 5 studies with 400 participants, there is limited but promising evidence that Quercetin may support Allergic Rhinitis management. Our evidence grade is C (Some Evidence).
How much Quercetin should I take for Allergic Rhinitis?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Headache, Tingling in extremities, Gastrointestinal discomfort, Low oral bioavailability (addressed by phytosome formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and Allergic Rhinitis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Allergic Rhinitis
References
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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。