Quercetin for Allergic Rhinitis
CResearch suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.
The Bottom Line
Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.
Key Study Findings
Population: None
Population: CRSwNP, allergic rhinitis, asthma (MR analysis)
Population: None
Population: Patients with seasonal or perennial allergic rhinitis
Population: In silico/computational models
Population: OVA-induced allergic rhinitis mouse model
Key Statistics
5
Studies
400
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 500-1,000 mg/day
- immunesupport:
- 500-1,500 mg/day
Upper limit: No established UL; GRAS up to 500 mg/day per FDA
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | 823 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| Quertal + antihistamines | 12 weeks | Positive | 100 |
Best taken: With meals (fat-containing meals improve absorption); often paired with vitamin C or bromelain for enhanced bioavailability
Safety & Side Effects
Reported Side Effects
- ⚠ Headache
- ⚠ Tingling in extremities
- ⚠ Gastrointestinal discomfort
- ⚠ Low oral bioavailability (addressed by phytosome formulations)
Known Interactions
- ● Cyclosporine (may increase drug levels)
- ● Fluoroquinolone antibiotics (may interfere with bacterial target)
- ● CYP3A4 and CYP2C8 substrates (may inhibit metabolism)
Tolerable upper intake: No established UL; GRAS up to 500 mg/day per FDA
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Quercetin help with Allergic Rhinitis?
How much Quercetin should I take for Allergic Rhinitis?
Are there side effects of Quercetin?
How strong is the evidence for Quercetin and Allergic Rhinitis?
Related Evidence
Other ingredients for Allergic Rhinitis
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.