Spirulina ： Allergic Rhinitis
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。A 2020 comparative trial found spirulina was more effective than cetirizine (a standard antihistamine) in improving allergic rhinitis symptoms. Earlier studies show enhancement of NK cell function in a majority of subjects.
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C
結論
A 2020 comparative trial found spirulina was more effective than cetirizine (a standard antihistamine) in improving allergic rhinitis symptoms. Earlier studies show enhancement of NK cell function in a majority of subjects.
Key Study Findings
Controlled Clinical Trial
6 weeks
Supplementation With Spirulina platensis Improves Tracheal Reactivity in Wistar Rats by Modulating Inflammation and Oxidative …
Dose: 50 mg/kg/day
vs: OVA-sensitized control without Spirulina
Outcome: Tracheal reactivity to acetylcholine and citric acid
効果: None
None
対象集団: OVA-sensitized Wistar rats
Other
12 weeks
Can selenium-enriched spirulina supplementation ameliorate sepsis outcomes in selenium-deficient animals?
Dose: 92%
vs: None
Outcome: by ICPMS
効果: or 4
None
対象集団: None
Randomized Controlled Trial
n=76
Open-label
Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK …
Dose: None
vs: Control group
Outcome: symptom control, assessed by the control of allergic …
効果: None
p = 0.035
対象集団: Allergic rhinitis patients
In Vitro
Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 …
Dose: None
vs: None
Outcome: IgE-mediated TNF-alpha and histamine release
効果: None
None
対象集団: RBL-2H3 mast cells
Review
Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Otorhinolaryngology patients (phytotherapy)
Review
Recent Patents of Complementary and Alternative Medicine for Allergic Rhinitis.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: allergic rhinitis patients
Key Statistics
3
研究数
150
参加者数
↑
Positive
C
グレード
Referenced Papers
Frontiers in pharmacology
2022
5 件の引用
Physiological reports
2021
3 件の引用
Clinical and translational …
2020
20 件の引用
Acta otorhinolaryngologica Italica …
2020
11 件の引用
Plants (Basel, Switzerland)
2018
23 件の引用
European annals of …
2017
16 件の引用
Recent patents on …
2015
16 件の引用
ISRN allergy
2013
19 件の引用
Current opinion in …
2009
26 件の引用
European archives of …
2008
91 件の引用
'Complementary ENT': a systematic review of commonly used supplements.
Systematic Review
The Journal of …
2007
39 件の引用
Journal of medicinal …
2005
195 件の引用
Zhong nan da …
2005
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 1-3 g/day
- immunesupport:
- 3-10 g/day
上限量： No established UL; 10 g/day widely studied
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| 50 mg/kg/day | 6 weeks | Positive | -- |
| 92% | 12 weeks | Positive | -- |
| None | -- | Positive | 76 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | 230 |
| None | -- | Positive | -- |
推奨摂取タイミング： With or without food
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort
- ⚠ Headache
- ⚠ Allergic reactions (rare)
- ⚠ Contamination risk from wild-harvested sources (microcystins, heavy metals)
- ⚠ May exacerbate autoimmune conditions (immunostimulatory)
既知の相互作用
- ● Immunosuppressant medications (may counteract immunosuppression)
- ● Anticoagulants (may have additive effects)
- ● Diabetes medications (may lower blood sugar)
耐容上限摂取量： No established UL; 10 g/day widely studied
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Spirulina help with Allergic Rhinitis?
Based on 3 studies with 150 participants, there is limited but promising evidence that Spirulina may support Allergic Rhinitis management. Our evidence grade is C (Some Evidence).
How much Spirulina should I take for Allergic Rhinitis?
Studies have used various dosages. A commonly studied range is 1-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Spirulina?
Reported side effects may include Gastrointestinal discomfort, Headache, Allergic reactions (rare), Contamination risk from wild-harvested sources (microcystins, heavy metals). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Spirulina and Allergic Rhinitis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Allergic Rhinitis
References
- [1] Aline de F Brito et al.. Front Pharmacol. 2022. Supplementation With Spirulina platensis Improves Tracheal Reactivity in Wistar Rats by Modulating Inflammation and Oxidative Stress. doi:10.3389/fphar.2022.826649 PubMed
- [2] Thomas Castel et al.. Physiol Rep. 2021. Can selenium-enriched spirulina supplementation ameliorate sepsis outcomes in selenium-deficient animals? doi:10.14814/phy2.14933 PubMed
- [3] Dimitrios I Mitsias et al.. Clin Transl Allergy. 2020. Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes. doi:10.1186/s13601-020-00313-2 PubMed
- [4] Morteza Nourollahian et al.. Acta Otorhinolaryngol Ital. 2020. Clinical comparison of the efficacy of spirulina platensis and cetirizine for treatment of allergic rhinitis. doi:10.14639/0392-100X-N0139 PubMed
- [5] Kurt Appel et al.. Plants (Basel). 2018. Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in … doi:10.3390/plants7010013 PubMed
- [6] O Laccourreye et al.. Eur Ann Otorhinolaryngol Head Neck Dis. 2017. Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology. doi:10.1016/j.anorl.2016.11.001 PubMed
- [7] Kam L Hon et al.. Recent Pat Inflamm Allergy Drug Discov. 2015. Recent Patents of Complementary and Alternative Medicine for Allergic Rhinitis. doi:10.2174/1872213x10666151119144718 PubMed
- [8] Ibrahim Sayin et al.. ISRN Allergy. 2013. Complementary therapies in allergic rhinitis. doi:10.1155/2013/938751 PubMed
- [9] Li-Xing Man. Curr Opin Otolaryngol Head Neck Surg. 2009. Complementary and alternative medicine for allergic rhinitis. doi:10.1097/MOO.0b013e3283295791 PubMed
- [10] Cemal Cingi et al.. Eur Arch Otorhinolaryngol. 2008. The effects of spirulina on allergic rhinitis. doi:10.1007/s00405-008-0642-8 PubMed
- [11] P D Karkos et al.. J Laryngol Otol. 2007. 'Complementary ENT': a systematic review of commonly used supplements. doi:10.1017/S002221510600449X PubMed
- [12] T K Mao et al.. J Med Food. 2005. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. doi:10.1089/jmf.2005.8.27 PubMed
- [13] Li-lan Chen et al.. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005. [Experimental study of spirulina platensis in treating allergic rhinitis in rats]. PubMed
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