Vitamin D için Autoimmune Conditions
AThe VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
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A
Sonuç
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
vs: None
Outcome: rheumatoid arthritis disease activity modulation through diet
Etki: None
None
Popülasyon: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
vs: None
Outcome: RA risk and disease activity
Etki: None
None
Popülasyon: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
vs: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
Etki: None
None
Popülasyon: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
vs: None
Outcome: Neuroprotection
Etki: None
None
Popülasyon: None
Key Statistics
3
Çalışmalar
25871
Katılımcılar
↑
Positive
A
Derece
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 atıf
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 atıf
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 atıf
Immunity & ageing …
2024
12 atıf
Frontiers in immunology
2024
9 atıf
Autoimmunity reviews
2024
6 atıf
Biochemical pharmacology
2024
6 atıf
Indian dermatology online …
2024
3 atıf
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 atıf
Biomolecules
2023
70 atıf
Autoimmunity reviews
2023
65 atıf
The American journal …
2023
37 atıf
Frontiers in immunology
2023
33 atıf
Nutrients
2023
24 atıf
Seminars in arthritis …
2023
17 atıf
Mini reviews in …
2023
9 atıf
Journal of cosmetic …
2023
4 atıf
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 atıf
International journal of …
2022
102 atıf
Endocrine connections
2022
50 atıf
Nutrients
2022
29 atıf
Pathophysiology : the …
2022
24 atıf
Frontiers in bioscience …
2022
17 atıf
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
2022
11 atıf
BMJ (Clinical research …
2022
9 atıf
Nederlands tijdschrift voor …
2022
1 atıf
Medical sciences (Basel, …
2021
157 atıf
International journal of …
2021
6 atıf
JAAD international
2021
5 atıf
Nutrients
2020
229 atıf
Calcified tissue international
2020
185 atıf
Nutrients
2020
41 atıf
Acta biochimica Polonica
2020
10 atıf
Advances in experimental …
2020
8 atıf
Journal of autoimmunity
2019
604 atıf
International journal of …
2019
109 atıf
The genetics of vitamin D.
Review
Bone
2019
62 atıf
Therapeutics and clinical …
2019
4 atıf
Journal of research …
2018
48 atıf
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 atıf
Thyroid : official …
2017
170 atıf
The Israel Medical …
2017
117 atıf
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 atıf
Clinical reviews in …
2017
46 atıf
Postepy dermatologii i …
2017
31 atıf
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 atıf
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 atıf
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 atıf
Postepy dermatologii i …
2016
59 atıf
Indian dermatology online …
2016
51 atıf
Current gastroenterology reports
2016
22 atıf
Nutrients
2015
210 atıf
Frontiers in immunology
2015
102 atıf
Journal of drugs …
2015
50 atıf
The Proceedings of …
2015
46 atıf
Clinica chimica acta; …
2015
43 atıf
Healthcare (Basel, Switzerland)
2015
7 atıf
Vitamin D and immunity.
Review
F1000prime reports
2014
79 atıf
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 atıf
Clinical reviews in …
2013
259 atıf
British journal of …
2013
156 atıf
Dermato-endocrinology
2013
62 atıf
Clinics and research …
2013
56 atıf
Multiple sclerosis.
Review
Global advances in …
2013
19 atıf
Presse medicale (Paris, …
2013
4 atıf
Journal of investigative …
2011
563 atıf
Vitamins and hormones
2011
25 atıf
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 atıf
Acta medica Indonesiana
2007
4 atıf
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 atıf
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 atıf
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Yaygın Kullanılan Dozajlar
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Üst sınır: 4,000 IU/day (100 mcg)
Araştırmalarda İncelenen Dozajlar
| Dozaj | Süre | Etki | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
En iyi alım zamanı: With a meal containing fat for better absorption
Safety & Side Effects
Bildirilen Yan Etkiler
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Bilinen Etkileşimler
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Tolere edilebilir üst alım: 4,000 IU/day (100 mcg)
Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
Şu durum için diğer içerikler: Autoimmune Conditions
Vitamin D diğer sağlık durumları için
FDA Sorumluluk Reddi: Bu ifadeler Gıda ve İlaç Dairesi (FDA) tarafından değerlendirilmemiştir. Bu web sitesindeki ürünler ve bilgiler herhangi bir hastalığı teşhis etmek, tedavi etmek, iyileştirmek veya önlemek amacıyla tasarlanmamıştır. Sunulan kanıt dereceleri, yayımlanmış hakemli araştırmalarımızın analizine dayanmaktadır ve tıbbi tavsiye niteliği taşımamaktadır. Herhangi bir takviye rejimine başlamadan önce her zaman sağlık uzmanınıza danışın.