Vitamin D cho Autoimmune Conditions

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'immunecited.com'; const params = 'ingredient\u003Dvitamin\u002Dd\u0026condition\u003Dautoimmune\u002Dconditions'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Kết luận

Key Study Findings

Review

Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.

Dose: None so với: None Outcome: rheumatoid arthritis disease activity modulation through diet Hiệu quả: None None

Đối tượng nghiên cứu: patients with rheumatoid arthritis

Review

The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …

Dose: None so với: None Outcome: RA risk and disease activity Hiệu quả: None None

Đối tượng nghiên cứu: Patients with rheumatoid arthritis

Review

Hypoparathyroidism: diagnosis, management and emerging therapies.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: None

Systematic Review

Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: Systematic review of nutraceuticals in rheumatoid arthritis

Controlled Clinical Trial 26 weeks

Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.

Dose: 4000 IU or 8000 IU daily so với: No supplementation Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI) Hiệu quả: None None

Đối tượng nghiên cứu: SLE patients (EULAR/ACR 2019 criteria)

Review

Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.

Dose: None so với: None Outcome: Neuroprotection Hiệu quả: None None

Đối tượng nghiên cứu: None

Key Statistics

Nghiên cứu

25871

Người tham gia

↑

Positive

Xếp hạng

Referenced Papers

Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity. Review

Nutrients 2026

Hypoparathyroidism: diagnosis, management and emerging therapies. Review

Nature reviews. Endocrinology 2025 14 trích dẫn

Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions. Systematic Review

Inflammopharmacology 2025 1 trích dẫn

The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review. Review

Nutrients 2025

Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus. Other

Cureus 2025

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled … RCT

Arthritis & rheumatology … 2024 25 trích dẫn

Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity. Review

Immunity & ageing … 2024 12 trích dẫn

Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Review

Frontiers in immunology 2024 9 trích dẫn

Auto-immuno-deficiency syndromes. Review

Autoimmunity reviews 2024 6 trích dẫn

Vitamin D and systemic lupus erythematosus: Causality and association with disease activity and therapeutics. Review

Biochemical pharmacology 2024 6 trích dẫn

Efficacy and Safety of Topical Tofacitinib for the Treatment of Alopecia Areata. Other

Indian dermatology online … 2024 3 trích dẫn

The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study. Systematic Review

Nutrients 2024 2 trích dẫn

Vitamin D and Autoimmune Rheumatic Diseases. Review

Biomolecules 2023 70 trích dẫn

Nutrition and its role in prevention and management of rheumatoid arthritis. Review

Autoimmunity reviews 2023 65 trích dẫn

Vitamin D and Microbiome: Molecular Interaction in Inflammatory Bowel Disease Pathogenesis. Review

The American journal … 2023 37 trích dẫn

Differential impact of environmental factors on systemic and localized autoimmunity. Review

Frontiers in immunology 2023 33 trích dẫn

Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice. Review

Nutrients 2023 24 trích dẫn

Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Other

Seminars in arthritis … 2023 17 trích dẫn

The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases. Review

Mini reviews in … 2023 9 trích dẫn

Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study. Other

Journal of cosmetic … 2023 4 trích dẫn

Determination of Serum 25-Hydroxyvitamin D Levels in Patients with Alopecia Areata. Other

Journal of Nepal … 2023

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. RCT

BMJ (Clinical research … 2022 307 trích dẫn

Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. Review

International journal of … 2022 102 trích dẫn

Autoimmune disease and interconnections with vitamin D. Review

Endocrine connections 2022 50 trích dẫn

Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL … RCT

Nutrients 2022 29 trích dẫn

Tuberculosis and Autoimmunity. Review

Pathophysiology : the … 2022 24 trích dẫn

Vitamin D in Prevention of Autoimmune Diseases. Review

Frontiers in bioscience … 2022 17 trích dẫn

Evaluation of several immune and inflammatory indicators and their association with alopecia areata. Other

Journal of cosmetic … 2022 11 trích dẫn

Vitamin D and fish oil supplements and risk of autoimmune disease. Other

BMJ (Clinical research … 2022 9 trích dẫn

[Vitamin D like one of few prevention possibilities for autoimmune diseases?]. RCT

Nederlands tijdschrift voor … 2022 1 trích dẫn

Epidemiology of Non-Hodgkin's Lymphoma. Review

Medical sciences (Basel, … 2021 157 trích dẫn

Alopecia Universalis Occurring after Alemtuzumab Treatment for Multiple Sclerosis. A Two-Year Follow-Up of Two Patients. Case Report

International journal of … 2021 6 trích dẫn

Determination of serum 25-hydroxyvitamin D levels in patients with alopecia areata and their comparison with levels in healthy controls: A … Other

JAAD international 2021 5 trích dẫn

Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations? Review

Nutrients 2020 229 trích dẫn

Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Review

Calcified tissue international 2020 185 trích dẫn

Vitamin D and Autoimmune Thyroid Disease-Cause, Consequence, or a Vicious Cycle? Review

Nutrients 2020 41 trích dẫn

Vitamin D in autoimmune bullous disease. Review

Acta biochimica Polonica 2020 10 trích dẫn

Epigenetics in Multiple Sclerosis. Review

Advances in experimental … 2020 8 trích dẫn

Systemic lupus erythematosus: Diagnosis and clinical management. Review

Journal of autoimmunity 2019 604 trích dẫn

Vitamin D and Human Health. Other

International journal of … 2019 109 trích dẫn

The genetics of vitamin D. Review

Bone 2019 62 trích dẫn

Vitamin D supplementation for the prevention or depletion of side effects of therapy with alemtuzumab in multiple sclerosis. Other

Therapeutics and clinical … 2019 4 trích dẫn

Vitamin D, the gut microbiome and inflammatory bowel disease. Review

Journal of research … 2018 48 trích dẫn

[Early reumatoid arthritis]. Review

Wiadomosci lekarskie (Warsaw, … 2018 2 trích dẫn

Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis. Review

Thyroid : official … 2017 170 trích dẫn

Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Review

The Israel Medical … 2017 117 trích dẫn

Cholesterolomics: An update. Review

Analytical biochemistry 2017 47 trích dẫn

Vitamin D Deficiency and Rheumatoid Arthritis. Review

Clinical reviews in … 2017 46 trích dẫn

25-hydroxyvitamin D status in patients with alopecia areata. Other

Postepy dermatologii i … 2017 31 trích dẫn

Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands. Review

Current medicinal chemistry 2017 14 trích dẫn

Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis. Meta-Analysis

PloS one 2016 152 trích dẫn

Vitamin D and autoimmunity. Review

Scandinavian journal of … 2016 81 trích dẫn

The role of serum vitamin D levels in vitiligo. Other

Postepy dermatologii i … 2016 59 trích dẫn

Serum Vitamin D in patients with alopecia areata. Other

Indian dermatology online … 2016 51 trích dẫn

Vitamin D and the Pathogenesis of Inflammatory Bowel Disease. Review

Current gastroenterology reports 2016 22 trích dẫn

Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Meta-Analysis

Nutrients 2015 210 trích dẫn

Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease. Review

Frontiers in immunology 2015 102 trích dẫn

Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study. Other

Journal of drugs … 2015 50 trích dẫn

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn? Review

The Proceedings of … 2015 46 trích dẫn

Vitamin D and immune function in chronic kidney disease. Review

Clinica chimica acta; … 2015 43 trích dẫn

The Role of Vitamin D in Inflammatory Bowel Disease. Review

Healthcare (Basel, Switzerland) 2015 7 trích dẫn

Vitamin D and immunity. Review

F1000prime reports 2014 79 trích dẫn

Pediatric vitiligo. Review

Pediatric clinics of … 2014 25 trích dẫn

Vitamin D in systemic and organ-specific autoimmune diseases. Review

Clinical reviews in … 2013 259 trích dẫn

Vitamin D in health and disease: a literature review. Review

British journal of … 2013 156 trích dẫn

Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata. Other

Dermato-endocrinology 2013 62 trích dẫn

Vitamin D in autoimmune liver disease. Review

Clinics and research … 2013 56 trích dẫn

Multiple sclerosis. Review

Global advances in … 2013 19 trích dẫn

[Vitamin D and autoimmunity]. Review

Presse medicale (Paris, … 2013 4 trích dẫn

Vitamin D and the immune system. Review

Journal of investigative … 2011 563 trích dẫn

Vitamin D and inflammatory bowel disease. Review

Vitamins and hormones 2011 25 trích dẫn

Melanoma and vitamin D. Review

Molecular oncology 2011

The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. Review

Nature clinical practice. … 2009 154 trích dẫn

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 trích dẫn

Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature. Review

Journal of the … 2006 45 trích dẫn

Chronic plaque psoriasis. Review

American family physician 2006

Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Review

Proceedings of the … 2000 281 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 600-800 IU/day
immunesupport:: 1,000-2,000 IU/day
deficiencycorrection:: 4,000-5,000 IU/day (under medical supervision)

Giới hạn trên: 4,000 IU/day (100 mcg)

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
4000 IU or 8000 IU daily	26 weeks	Positive	--
None	--	Positive	--
None	--	Neutral	--
None	--	Neutral	--

Thời điểm dùng tốt nhất: With a meal containing fat for better absorption

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
⚠ Kidney stones with excessive long-term use
⚠ Constipation
⚠ Metallic taste

Tương tác đã biết

● Thiazide diuretics (may increase risk of hypercalcemia)
● Corticosteroids (reduce vitamin D absorption and metabolism)
● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
● Statins (vitamin D may affect statin metabolism)

Mức hấp thụ tối đa cho phép: 4,000 IU/day (100 mcg)

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Vitamin D help with Autoimmune Conditions?

Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).

How much Vitamin D should I take for Autoimmune Conditions?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Autoimmune Conditions?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Autoimmune Conditions

Omega-3 Fatty Acids (EPA/DHA) B

Vitamin D cho các tình trạng khác

Upper Respiratory Tract Infections A Immune Aging (Immunosenescence) B

Đánh giá nhanh

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest …

Evidence Strength92%

High confidence

Phân tích nghiên cứu

RCT (4)Meta (2)Other (0)

So sánh lựa chọn thay thế

Xem các thành phần khác so sánh như thế nào cho tình trạng này.

Xem tất cả thành phần cho Autoimmune Conditions

Tìm hiểu thêm

Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.