Selenium 用于 Vaccine Response Support
CAdequate selenium status is associated with enhanced natural killer cell activity and improved vaccine response, particularly in elderly populations. Supplementation in deficient individuals may help restore optimal immune responses to vaccination.
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C
结论
Adequate selenium status is associated with enhanced natural killer cell activity and improved vaccine response, particularly in elderly populations. Supplementation in deficient individuals may help restore optimal immune responses to vaccination.
Key Study Findings
Systematic Review and Meta-Analysis
n=7014
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Dose: None
vs: Placebo
效果: Standardized mean differences reported for each element and disease combination (specific values not
None
Review
A scoping review: the impact of nutritional status on the efficacy, effectiveness, and immunogenicity of …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Scoping review: nutritional status and COVID-19 vaccine
Review
Potential Applications and Risks of Supranutritional Selenium Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: A …
Dose: None
vs: None
Outcome: MASLD treatment and prevention
效果: None
None
研究人群: Patients with metabolic steatotic liver disease (review)
Observational Study
n=44
Unveiling the micronutrient-immunity puzzle in inactivated COVID-19 vaccination: A comprehensive analysis of circulating micronutrient levels …
Dose: Fe, Zn, Cu, Se, vitamins A, D, E (measured)
vs: Pre-vaccination vs post-booster
Outcome: Antibody response association with micronutrients
效果: None
None
研究人群: Healthy adults post-COVID-19 vaccination
Other
Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviate dextran sulfate sodium-induced colitis in …
Dose: None
vs: None
Outcome: Colitis severity
效果: None
None
研究人群: Mouse model
Other
Effect of parenteral micronutrient supplementation at birth on immunity, growth, and health in preweaning dairy …
Dose: 4 g
vs: None
Outcome: Oxidative stress markers
效果: None
None
研究人群: None
Key Statistics
5
研究数量
400
受试者
↑
Positive
C
等级
Referenced Papers
Nutrients
2025
3 次引用
Tropical diseases, travel …
2025
1 次引用
Trace Elements and Risk of Immune-Mediated Skin Disease: A Systematic Review and Meta-analysis.
Meta-Analysis
Nutrition reviews
2025
Food & function
2024
6 次引用
Journal of dairy …
2024
4 次引用
Journal of medical …
2024
Selenium and immune function: a systematic review and meta-analysis of experimental human studies.
Meta-Analysis
The American journal …
2023
57 次引用
Selenium status and immunity.
Systematic Review
The Proceedings of …
2023
27 次引用
European thyroid journal
2023
4 次引用
Nutrients
2022
5 次引用
Clinical nutrition ESPEN
2021
27 次引用
BMC veterinary research
2021
24 次引用
Physiological reports
2021
3 次引用
Biological trace element …
2020
10 次引用
Biological trace element …
2015
1 次引用
Annual review of …
2014
9 次引用
International journal of …
2013
104 次引用
European journal of …
2012
225 次引用
Minerva urologica e …
2012
Current opinion in …
2010
18 次引用
Journal of the …
2010
11 次引用
Archives of internal …
2007
8 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 55 mcg/day
- immunesupport:
- 100-200 mcg/day
上限： 400 mcg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | 7014 |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Fe, Zn, Cu, Se, vitamins A, D, E (measured) | -- | Positive | 44 |
| None | -- | Positive | -- |
| 4 g | -- | Positive | -- |
| Selenium supplement (dose not specified) | -- | Neutral | 105 |
| Various inorganic and organic selenium forms; dose-response assessed via plasma selenium concentrati | -- | Mixed | -- |
最佳服用时间： With meals
Safety & Side Effects
已报告的副作用
- ⚠ Selenosis at chronic high doses (hair loss, nail brittleness, garlic breath odor)
- ⚠ Nausea and diarrhea
- ⚠ Fatigue and irritability
- ⚠ Nerve damage (peripheral neuropathy) at very high chronic doses
已知相互作用
- ● Cisplatin and other chemotherapy agents (selenium may modify effects)
- ● Statins (selenium may affect cholesterol metabolism)
- ● Birth control pills (may lower selenium levels)
- ● Gold salts (mutual reduction of effectiveness)
可耐受最高摄入量： 400 mcg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Selenium help with Vaccine Response Support?
Based on 5 studies with 400 participants, there is limited but promising evidence that Selenium may support Vaccine Response Support management. Our evidence grade is C (Some Evidence).
How much Selenium should I take for Vaccine Response Support?
Studies have used various dosages. A commonly studied range is 55 mcg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Selenium?
Reported side effects may include Selenosis at chronic high doses (hair loss, nail brittleness, garlic breath odor), Nausea and diarrhea, Fatigue and irritability, Nerve damage (peripheral neuropathy) at very high chronic doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Selenium and Vaccine Response Support?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
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