Vitamin D لـ Autoimmune Conditions

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.

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الخلاصة

Key Study Findings

Review

Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.

Dose: None مقابل: None Outcome: rheumatoid arthritis disease activity modulation through diet التأثير: None None

المجتمع المدروس: patients with rheumatoid arthritis

Review

The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …

Dose: None مقابل: None Outcome: RA risk and disease activity التأثير: None None

المجتمع المدروس: Patients with rheumatoid arthritis

Review

Hypoparathyroidism: diagnosis, management and emerging therapies.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Systematic Review

Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Systematic review of nutraceuticals in rheumatoid arthritis

Controlled Clinical Trial 26 weeks

Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.

Dose: 4000 IU or 8000 IU daily مقابل: No supplementation Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI) التأثير: None None

المجتمع المدروس: SLE patients (EULAR/ACR 2019 criteria)

Review

Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.

Dose: None مقابل: None Outcome: Neuroprotection التأثير: None None

المجتمع المدروس: None

Key Statistics

الدراسات

25871

المشاركون

↑

Positive

التقييم

Referenced Papers

Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity. Review

Nutrients 2026

Hypoparathyroidism: diagnosis, management and emerging therapies. Review

Nature reviews. Endocrinology 2025 14 اقتباسات

Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions. Systematic Review

Inflammopharmacology 2025 1 اقتباسات

The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review. Review

Nutrients 2025

Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus. Other

Cureus 2025

Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled … RCT

Arthritis & rheumatology … 2024 25 اقتباسات

Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity. Review

Immunity & ageing … 2024 12 اقتباسات

Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Review

Frontiers in immunology 2024 9 اقتباسات

Auto-immuno-deficiency syndromes. Review

Autoimmunity reviews 2024 6 اقتباسات

Vitamin D and systemic lupus erythematosus: Causality and association with disease activity and therapeutics. Review

Biochemical pharmacology 2024 6 اقتباسات

Efficacy and Safety of Topical Tofacitinib for the Treatment of Alopecia Areata. Other

Indian dermatology online … 2024 3 اقتباسات

The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study. Systematic Review

Nutrients 2024 2 اقتباسات

Vitamin D and Autoimmune Rheumatic Diseases. Review

Biomolecules 2023 70 اقتباسات

Nutrition and its role in prevention and management of rheumatoid arthritis. Review

Autoimmunity reviews 2023 65 اقتباسات

Vitamin D and Microbiome: Molecular Interaction in Inflammatory Bowel Disease Pathogenesis. Review

The American journal … 2023 37 اقتباسات

Differential impact of environmental factors on systemic and localized autoimmunity. Review

Frontiers in immunology 2023 33 اقتباسات

Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice. Review

Nutrients 2023 24 اقتباسات

Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Other

Seminars in arthritis … 2023 17 اقتباسات

The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases. Review

Mini reviews in … 2023 9 اقتباسات

Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study. Other

Journal of cosmetic … 2023 4 اقتباسات

Determination of Serum 25-Hydroxyvitamin D Levels in Patients with Alopecia Areata. Other

Journal of Nepal … 2023

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. RCT

BMJ (Clinical research … 2022 307 اقتباسات

Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. Review

International journal of … 2022 102 اقتباسات

Autoimmune disease and interconnections with vitamin D. Review

Endocrine connections 2022 50 اقتباسات

Effects of Vitamin D3 and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL … RCT

Nutrients 2022 29 اقتباسات

Tuberculosis and Autoimmunity. Review

Pathophysiology : the … 2022 24 اقتباسات

Vitamin D in Prevention of Autoimmune Diseases. Review

Frontiers in bioscience … 2022 17 اقتباسات

Evaluation of several immune and inflammatory indicators and their association with alopecia areata. Other

Journal of cosmetic … 2022 11 اقتباسات

Vitamin D and fish oil supplements and risk of autoimmune disease. Other

BMJ (Clinical research … 2022 9 اقتباسات

[Vitamin D like one of few prevention possibilities for autoimmune diseases?]. RCT

Nederlands tijdschrift voor … 2022 1 اقتباسات

Epidemiology of Non-Hodgkin's Lymphoma. Review

Medical sciences (Basel, … 2021 157 اقتباسات

Alopecia Universalis Occurring after Alemtuzumab Treatment for Multiple Sclerosis. A Two-Year Follow-Up of Two Patients. Case Report

International journal of … 2021 6 اقتباسات

Determination of serum 25-hydroxyvitamin D levels in patients with alopecia areata and their comparison with levels in healthy controls: A … Other

JAAD international 2021 5 اقتباسات

Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations? Review

Nutrients 2020 229 اقتباسات

Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Review

Calcified tissue international 2020 185 اقتباسات

Vitamin D and Autoimmune Thyroid Disease-Cause, Consequence, or a Vicious Cycle? Review

Nutrients 2020 41 اقتباسات

Vitamin D in autoimmune bullous disease. Review

Acta biochimica Polonica 2020 10 اقتباسات

Epigenetics in Multiple Sclerosis. Review

Advances in experimental … 2020 8 اقتباسات

Systemic lupus erythematosus: Diagnosis and clinical management. Review

Journal of autoimmunity 2019 604 اقتباسات

Vitamin D and Human Health. Other

International journal of … 2019 109 اقتباسات

The genetics of vitamin D. Review

Bone 2019 62 اقتباسات

Vitamin D supplementation for the prevention or depletion of side effects of therapy with alemtuzumab in multiple sclerosis. Other

Therapeutics and clinical … 2019 4 اقتباسات

Vitamin D, the gut microbiome and inflammatory bowel disease. Review

Journal of research … 2018 48 اقتباسات

[Early reumatoid arthritis]. Review

Wiadomosci lekarskie (Warsaw, … 2018 2 اقتباسات

Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis. Review

Thyroid : official … 2017 170 اقتباسات

Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Review

The Israel Medical … 2017 117 اقتباسات

Cholesterolomics: An update. Review

Analytical biochemistry 2017 47 اقتباسات

Vitamin D Deficiency and Rheumatoid Arthritis. Review

Clinical reviews in … 2017 46 اقتباسات

25-hydroxyvitamin D status in patients with alopecia areata. Other

Postepy dermatologii i … 2017 31 اقتباسات

Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands. Review

Current medicinal chemistry 2017 14 اقتباسات

Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis. Meta-Analysis

PloS one 2016 152 اقتباسات

Vitamin D and autoimmunity. Review

Scandinavian journal of … 2016 81 اقتباسات

The role of serum vitamin D levels in vitiligo. Other

Postepy dermatologii i … 2016 59 اقتباسات

Serum Vitamin D in patients with alopecia areata. Other

Indian dermatology online … 2016 51 اقتباسات

Vitamin D and the Pathogenesis of Inflammatory Bowel Disease. Review

Current gastroenterology reports 2016 22 اقتباسات

Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Meta-Analysis

Nutrients 2015 210 اقتباسات

Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease. Review

Frontiers in immunology 2015 102 اقتباسات

Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study. Other

Journal of drugs … 2015 50 اقتباسات

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn? Review

The Proceedings of … 2015 46 اقتباسات

Vitamin D and immune function in chronic kidney disease. Review

Clinica chimica acta; … 2015 43 اقتباسات

The Role of Vitamin D in Inflammatory Bowel Disease. Review

Healthcare (Basel, Switzerland) 2015 7 اقتباسات

Vitamin D and immunity. Review

F1000prime reports 2014 79 اقتباسات

Pediatric vitiligo. Review

Pediatric clinics of … 2014 25 اقتباسات

Vitamin D in systemic and organ-specific autoimmune diseases. Review

Clinical reviews in … 2013 259 اقتباسات

Vitamin D in health and disease: a literature review. Review

British journal of … 2013 156 اقتباسات

Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata. Other

Dermato-endocrinology 2013 62 اقتباسات

Vitamin D in autoimmune liver disease. Review

Clinics and research … 2013 56 اقتباسات

Multiple sclerosis. Review

Global advances in … 2013 19 اقتباسات

[Vitamin D and autoimmunity]. Review

Presse medicale (Paris, … 2013 4 اقتباسات

Vitamin D and the immune system. Review

Journal of investigative … 2011 563 اقتباسات

Vitamin D and inflammatory bowel disease. Review

Vitamins and hormones 2011 25 اقتباسات

Melanoma and vitamin D. Review

Molecular oncology 2011

The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. Review

Nature clinical practice. … 2009 154 اقتباسات

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 اقتباسات

Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature. Review

Journal of the … 2006 45 اقتباسات

Chronic plaque psoriasis. Review

American family physician 2006

Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Review

Proceedings of the … 2000 281 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 600-800 IU/day
immunesupport:: 1,000-2,000 IU/day
deficiencycorrection:: 4,000-5,000 IU/day (under medical supervision)

الحد الأعلى: 4,000 IU/day (100 mcg)

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
4000 IU or 8000 IU daily	26 weeks	Positive	--
None	--	Positive	--
None	--	Neutral	--
None	--	Neutral	--

أفضل وقت للتناول: With a meal containing fat for better absorption

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
⚠ Kidney stones with excessive long-term use
⚠ Constipation
⚠ Metallic taste

التفاعلات المعروفة

● Thiazide diuretics (may increase risk of hypercalcemia)
● Corticosteroids (reduce vitamin D absorption and metabolism)
● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
● Statins (vitamin D may affect statin metabolism)

الحد الأقصى المسموح به: 4,000 IU/day (100 mcg)

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Vitamin D help with Autoimmune Conditions?

Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).

How much Vitamin D should I take for Autoimmune Conditions?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Autoimmune Conditions?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.

Related Evidence

مكونات أخرى لـ Autoimmune Conditions

Omega-3 Fatty Acids (EPA/DHA) B

Vitamin D لحالات أخرى

Upper Respiratory Tract Infections A Immune Aging (Immunosenescence) B

الخلاصة السريعة

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest …

Evidence Strength92%

High confidence

تفصيل الدراسات

RCT (4)Meta (2)Other (0)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Autoimmune Conditions

اعرف المزيد

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.