Cordyceps para Immune Aging (Immunosenescence)
C Evidencia Evidencia limitada de estudios pequeños, pero existen algunas señales positivas.A double-blind randomized controlled trial found Cordyceps mycelium extract showed 38.8% enhancement of NK cell cytotoxic activity after 8 weeks in healthy adults. Supports cell-mediated immunity and may enhance immune surveillance capacity.
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C
Conclusión
A double-blind randomized controlled trial found Cordyceps mycelium extract showed 38.8% enhancement of NK cell cytotoxic activity after 8 weeks in healthy adults. Supports cell-mediated immunity and may enhance immune surveillance capacity.
Key Study Findings
Review
n=321
Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: healthy individuals aged 16-35 from 5 intervention studies (2017-2024)
Other
The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo.
Dose: None
vs: LPS-induced lung injury mouse model vs control
Outcome: Immune cell infiltration and inflammatory cytokines
Efecto: None
None
Población: LPS-induced lung injury mouse model
Controlled Clinical Trial
n=24
3 weeks
Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota …
Dose: 60 mg/kg in basal diet
vs: LPS-challenged control (basal diet only)
Outcome: Colonic morphology and microbiota composition
Efecto: None
None
Población: Weaned castrated piglets challenged with LPS
Review
Ergogenic Aid by Cordyceps: Does It Work??
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Review of Cordyceps as ergogenic aid in human studies
In Vitro
n=24
Transcriptomic and Metabolomic Analyses Reveal the Attenuating Role of Cordycepin and Cordyceps militaris Extract on …
Dose: Cordycepin (CPN) or C. militaris extract (CME)
vs: Basal diet + LPS challenge
Outcome: Liver injury markers and transcriptome changes
Efecto: None
None
Población: Weaned piglets (4 groups, n=6)
Randomized Controlled Trial
2 weeks
Double-blind
Beet supplementation mitigates post-exercise inflammation.
Dose: 212 mg
vs: Placebo
Outcome: Inflammatory markers
Efecto: None
p < 0.001
Población: None
Key Statistics
3
Estudios
100
Participantes
↑
Positive
C
Calificación
Referenced Papers
Nutrients
2026
Journal of microbiology …
2025
2 citas
Current nutrition reports
2025
2 citas
Frontiers in immunology
2025
1 citas
Frontiers in nutrition
2024
8 citas
BMC veterinary research
2024
7 citas
Animals : an …
2024
1 citas
International journal of …
2023
40 citas
Molecules (Basel, Switzerland)
2023
40 citas
Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies.
Systematic Review
Current oncology reports
2023
27 citas
Frontiers in pharmacology
2023
26 citas
Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation.
Other
Cureus
2023
5 citas
Integrative medicine (Encinitas, …
2023
2 citas
Molecules (Basel, Switzerland)
2022
34 citas
Integrative medicine considerations for convalescence from mild-to-moderate COVID-19 disease.
Review
Explore (New York, …
2022
34 citas
Molecules (Basel, Switzerland)
2020
153 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 1-3 g/day extract
- immunesupport:
- 1,000-3,000 mg standardized extract/day
Límite superior: No established UL
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Mixed | 321 |
| None | -- | Positive | -- |
| 60 mg/kg in basal diet | 3 weeks | Positive | 24 |
| None | -- | Mixed | -- |
| Cordycepin (CPN) or C. militaris extract (CME) | -- | Positive | 24 |
| 212 mg | 2 weeks | Neutral | -- |
| None | -- | Positive | -- |
| Mushroom extracts (various species) | -- | Positive | -- |
Mejor momento para tomar: Morning or early afternoon; with or without food
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Mild gastrointestinal discomfort
- ⚠ Dry mouth
- ⚠ Nausea (rare)
- ⚠ Potential interaction with autoimmune conditions
Interacciones conocidas
- ● Immunosuppressant medications (may counteract immunosuppression)
- ● Anticoagulants (may increase bleeding risk)
- ● Diabetes medications (may enhance blood sugar lowering)
Ingesta máxima tolerable: No established UL
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Cordyceps help with Immune Aging (Immunosenescence)?
Based on 3 studies with 100 participants, there is limited but promising evidence that Cordyceps may support Immune Aging (Immunosenescence) management. Our evidence grade is C (Some Evidence).
How much Cordyceps should I take for Immune Aging (Immunosenescence)?
Studies have used various dosages. A commonly studied range is 1-3 g/day extract. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Cordyceps?
Reported side effects may include Mild gastrointestinal discomfort, Dry mouth, Nausea (rare), Potential interaction with autoimmune conditions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Cordyceps and Immune Aging (Immunosenescence)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Immune Aging (Immunosenescence)
References
- [1] Maciej Jędrejko et al.. Nutrients. 2026. Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans-A Narrative Review. doi:10.3390/nu18050781 PubMed
- [2] Hye Kang Seong et al.. J Microbiol Biotechnol. 2025. The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo. doi:10.4014/jmb.2412.12043 PubMed
- [3] Luthfia Dewi et al.. Curr Nutr Rep. 2025. Ergogenic Aid by Cordyceps: Does It Work?? doi:10.1007/s13668-025-00690-9 PubMed
- [4] Shijie Xiong et al.. Front Immunol. 2025. Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota and metabolite profiles. doi:10.3389/fimmu.2025.1530098 PubMed
- [5] David C Nieman et al.. Front Nutr. 2024. Beet supplementation mitigates post-exercise inflammation. doi:10.3389/fnut.2024.1408804 PubMed
- [6] Chia-Chen Pi et al.. BMC Vet Res. 2024. Synergistic fermentation of Cordyceps militaris and herbal substrates boosts grower pig antioxidant and immune function. doi:10.1186/s12917-024-04338-8 PubMed
- [7] Ding Tan et al.. Animals (Basel). 2024. Transcriptomic and Metabolomic Analyses Reveal the Attenuating Role of Cordycepin and Cordyceps militaris Extract on Acute Liver Injury Induced by … doi:10.3390/ani14192873 PubMed
- [8] Marzia Bruna Gariboldi et al.. Int J Mol Sci. 2023. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. doi:10.3390/ijms241210120 PubMed
- [9] Mohammad Zaki Shamim et al.. Molecules. 2023. Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment. doi:10.3390/molecules28062837 PubMed
- [10] Santhosshi Narayanan et al.. Curr Oncol Rep. 2023. Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies. doi:10.1007/s11912-023-01408-2 PubMed
- [11] Xinyuan Liu et al.. Front Pharmacol. 2023. Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites. doi:10.3389/fphar.2023.1134429 PubMed
- [12] Siddharth Dubhashi et al.. Cureus. 2023. Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation. doi:10.7759/cureus.43731 PubMed
- [13] Allison Thompson et al.. Integr Med (Encinitas). 2023. A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease. PubMed
- [14] Yu Zhang et al.. Molecules. 2022. Medicinal Fungi with Antiviral Effect. doi:10.3390/molecules27144457 PubMed
- [15] Lise Alschuler et al.. Explore (NY). 2022. Integrative medicine considerations for convalescence from mild-to-moderate COVID-19 disease. doi:10.1016/j.explore.2020.12.005 PubMed
- [16] Syed Amir Ashraf et al.. Molecules. 2020. Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic … doi:10.3390/molecules25122735 PubMed
Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.