Cordyceps untuk Immune Aging (Immunosenescence)
C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.A double-blind randomized controlled trial found Cordyceps mycelium extract showed 38.8% enhancement of NK cell cytotoxic activity after 8 weeks in healthy adults. Supports cell-mediated immunity and may enhance immune surveillance capacity.
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C
Kesimpulan
A double-blind randomized controlled trial found Cordyceps mycelium extract showed 38.8% enhancement of NK cell cytotoxic activity after 8 weeks in healthy adults. Supports cell-mediated immunity and may enhance immune surveillance capacity.
Key Study Findings
Review
n=321
Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in …
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: healthy individuals aged 16-35 from 5 intervention studies (2017-2024)
Other
The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo.
Dose: None
vs: LPS-induced lung injury mouse model vs control
Outcome: Immune cell infiltration and inflammatory cytokines
Efek: None
None
Populasi: LPS-induced lung injury mouse model
Controlled Clinical Trial
n=24
3 weeks
Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota …
Dose: 60 mg/kg in basal diet
vs: LPS-challenged control (basal diet only)
Outcome: Colonic morphology and microbiota composition
Efek: None
None
Populasi: Weaned castrated piglets challenged with LPS
Review
Ergogenic Aid by Cordyceps: Does It Work??
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: Review of Cordyceps as ergogenic aid in human studies
In Vitro
n=24
Transcriptomic and Metabolomic Analyses Reveal the Attenuating Role of Cordycepin and Cordyceps militaris Extract on …
Dose: Cordycepin (CPN) or C. militaris extract (CME)
vs: Basal diet + LPS challenge
Outcome: Liver injury markers and transcriptome changes
Efek: None
None
Populasi: Weaned piglets (4 groups, n=6)
Randomized Controlled Trial
2 weeks
Double-blind
Beet supplementation mitigates post-exercise inflammation.
Dose: 212 mg
vs: Placebo
Outcome: Inflammatory markers
Efek: None
p < 0.001
Populasi: None
Key Statistics
3
Studi
100
Peserta
↑
Positive
C
Peringkat
Referenced Papers
Nutrients
2026
Journal of microbiology …
2025
2 sitasi
Current nutrition reports
2025
2 sitasi
Frontiers in immunology
2025
1 sitasi
Frontiers in nutrition
2024
8 sitasi
BMC veterinary research
2024
7 sitasi
Animals : an …
2024
1 sitasi
International journal of …
2023
40 sitasi
Molecules (Basel, Switzerland)
2023
40 sitasi
Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies.
Systematic Review
Current oncology reports
2023
27 sitasi
Frontiers in pharmacology
2023
26 sitasi
Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation.
Other
Cureus
2023
5 sitasi
Integrative medicine (Encinitas, …
2023
2 sitasi
Molecules (Basel, Switzerland)
2022
34 sitasi
Integrative medicine considerations for convalescence from mild-to-moderate COVID-19 disease.
Review
Explore (New York, …
2022
34 sitasi
Molecules (Basel, Switzerland)
2020
153 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 1-3 g/day extract
- immunesupport:
- 1,000-3,000 mg standardized extract/day
Batas atas: No established UL
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Mixed | 321 |
| None | -- | Positive | -- |
| 60 mg/kg in basal diet | 3 weeks | Positive | 24 |
| None | -- | Mixed | -- |
| Cordycepin (CPN) or C. militaris extract (CME) | -- | Positive | 24 |
| 212 mg | 2 weeks | Neutral | -- |
| None | -- | Positive | -- |
| Mushroom extracts (various species) | -- | Positive | -- |
Waktu terbaik diminum: Morning or early afternoon; with or without food
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Mild gastrointestinal discomfort
- ⚠ Dry mouth
- ⚠ Nausea (rare)
- ⚠ Potential interaction with autoimmune conditions
Interaksi yang Diketahui
- ● Immunosuppressant medications (may counteract immunosuppression)
- ● Anticoagulants (may increase bleeding risk)
- ● Diabetes medications (may enhance blood sugar lowering)
Asupan atas yang dapat ditoleransi: No established UL
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Cordyceps help with Immune Aging (Immunosenescence)?
Based on 3 studies with 100 participants, there is limited but promising evidence that Cordyceps may support Immune Aging (Immunosenescence) management. Our evidence grade is C (Some Evidence).
How much Cordyceps should I take for Immune Aging (Immunosenescence)?
Studies have used various dosages. A commonly studied range is 1-3 g/day extract. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Cordyceps?
Reported side effects may include Mild gastrointestinal discomfort, Dry mouth, Nausea (rare), Potential interaction with autoimmune conditions. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Cordyceps and Immune Aging (Immunosenescence)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 3 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Immune Aging (Immunosenescence)
References
- [1] Maciej Jędrejko et al.. Nutrients. 2026. Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans-A Narrative Review. doi:10.3390/nu18050781 PubMed
- [2] Hye Kang Seong et al.. J Microbiol Biotechnol. 2025. The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo. doi:10.4014/jmb.2412.12043 PubMed
- [3] Luthfia Dewi et al.. Curr Nutr Rep. 2025. Ergogenic Aid by Cordyceps: Does It Work?? doi:10.1007/s13668-025-00690-9 PubMed
- [4] Shijie Xiong et al.. Front Immunol. 2025. Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota and metabolite profiles. doi:10.3389/fimmu.2025.1530098 PubMed
- [5] David C Nieman et al.. Front Nutr. 2024. Beet supplementation mitigates post-exercise inflammation. doi:10.3389/fnut.2024.1408804 PubMed
- [6] Chia-Chen Pi et al.. BMC Vet Res. 2024. Synergistic fermentation of Cordyceps militaris and herbal substrates boosts grower pig antioxidant and immune function. doi:10.1186/s12917-024-04338-8 PubMed
- [7] Ding Tan et al.. Animals (Basel). 2024. Transcriptomic and Metabolomic Analyses Reveal the Attenuating Role of Cordycepin and Cordyceps militaris Extract on Acute Liver Injury Induced by … doi:10.3390/ani14192873 PubMed
- [8] Marzia Bruna Gariboldi et al.. Int J Mol Sci. 2023. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. doi:10.3390/ijms241210120 PubMed
- [9] Mohammad Zaki Shamim et al.. Molecules. 2023. Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment. doi:10.3390/molecules28062837 PubMed
- [10] Santhosshi Narayanan et al.. Curr Oncol Rep. 2023. Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies. doi:10.1007/s11912-023-01408-2 PubMed
- [11] Xinyuan Liu et al.. Front Pharmacol. 2023. Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites. doi:10.3389/fphar.2023.1134429 PubMed
- [12] Siddharth Dubhashi et al.. Cureus. 2023. Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation. doi:10.7759/cureus.43731 PubMed
- [13] Allison Thompson et al.. Integr Med (Encinitas). 2023. A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease. PubMed
- [14] Yu Zhang et al.. Molecules. 2022. Medicinal Fungi with Antiviral Effect. doi:10.3390/molecules27144457 PubMed
- [15] Lise Alschuler et al.. Explore (NY). 2022. Integrative medicine considerations for convalescence from mild-to-moderate COVID-19 disease. doi:10.1016/j.explore.2020.12.005 PubMed
- [16] Syed Amir Ashraf et al.. Molecules. 2020. Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic … doi:10.3390/molecules25122735 PubMed
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