Vitamin D para Autoimmune Conditions
AThe VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
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A
Conclusión
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
vs: None
Outcome: rheumatoid arthritis disease activity modulation through diet
Efecto: None
None
Población: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
vs: None
Outcome: RA risk and disease activity
Efecto: None
None
Población: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
vs: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
Efecto: None
None
Población: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
vs: None
Outcome: Neuroprotection
Efecto: None
None
Población: None
Key Statistics
3
Estudios
25871
Participantes
↑
Positive
A
Calificación
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 citas
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 citas
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 citas
Immunity & ageing …
2024
12 citas
Frontiers in immunology
2024
9 citas
Autoimmunity reviews
2024
6 citas
Biochemical pharmacology
2024
6 citas
Indian dermatology online …
2024
3 citas
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 citas
Biomolecules
2023
70 citas
Autoimmunity reviews
2023
65 citas
The American journal …
2023
37 citas
Frontiers in immunology
2023
33 citas
Nutrients
2023
24 citas
Seminars in arthritis …
2023
17 citas
Mini reviews in …
2023
9 citas
Journal of cosmetic …
2023
4 citas
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 citas
International journal of …
2022
102 citas
Endocrine connections
2022
50 citas
Nutrients
2022
29 citas
Pathophysiology : the …
2022
24 citas
Frontiers in bioscience …
2022
17 citas
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
2022
11 citas
BMJ (Clinical research …
2022
9 citas
Nederlands tijdschrift voor …
2022
1 citas
Medical sciences (Basel, …
2021
157 citas
International journal of …
2021
6 citas
JAAD international
2021
5 citas
Nutrients
2020
229 citas
Calcified tissue international
2020
185 citas
Nutrients
2020
41 citas
Acta biochimica Polonica
2020
10 citas
Advances in experimental …
2020
8 citas
Journal of autoimmunity
2019
604 citas
International journal of …
2019
109 citas
The genetics of vitamin D.
Review
Bone
2019
62 citas
Therapeutics and clinical …
2019
4 citas
Journal of research …
2018
48 citas
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 citas
Thyroid : official …
2017
170 citas
The Israel Medical …
2017
117 citas
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 citas
Clinical reviews in …
2017
46 citas
Postepy dermatologii i …
2017
31 citas
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 citas
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 citas
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 citas
Postepy dermatologii i …
2016
59 citas
Indian dermatology online …
2016
51 citas
Current gastroenterology reports
2016
22 citas
Nutrients
2015
210 citas
Frontiers in immunology
2015
102 citas
Journal of drugs …
2015
50 citas
The Proceedings of …
2015
46 citas
Clinica chimica acta; …
2015
43 citas
Healthcare (Basel, Switzerland)
2015
7 citas
Vitamin D and immunity.
Review
F1000prime reports
2014
79 citas
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 citas
Clinical reviews in …
2013
259 citas
British journal of …
2013
156 citas
Dermato-endocrinology
2013
62 citas
Clinics and research …
2013
56 citas
Multiple sclerosis.
Review
Global advances in …
2013
19 citas
Presse medicale (Paris, …
2013
4 citas
Journal of investigative …
2011
563 citas
Vitamins and hormones
2011
25 citas
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 citas
Acta medica Indonesiana
2007
4 citas
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 citas
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 citas
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Límite superior: 4,000 IU/day (100 mcg)
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
Mejor momento para tomar: With a meal containing fat for better absorption
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Interacciones conocidas
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Ingesta máxima tolerable: 4,000 IU/day (100 mcg)
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Autoimmune Conditions
Vitamin D para otras condiciones
Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.