What is the recommended dosage for Omega-3 Fatty Acids (EPA/DHA)?

General: 250-500 mg combined EPA/DHA/day; Anti Inflammatory: 1,000-3,000 mg combined EPA/DHA/day

What are the side effects of Omega-3 Fatty Acids (EPA/DHA)?

Potential side effects include: Fishy aftertaste and burping, Gastrointestinal discomfort (nausea, diarrhea), Increased bleeding risk at high doses, Potential LDL cholesterol increase at very high doses.

What is omega-3 and how does it support immune function?

Omega-3 fatty acids (EPA and DHA) are essential polyunsaturated fats found in fish oil and algae. They play a role in resolving inflammation through specialized pro-resolving mediators (SPMs) and have been studied for their effects on immune cell membrane function.

What dosage of omega-3 has been studied for immune-related outcomes?

Clinical trials have used omega-3 doses of 1–4 g per day of combined EPA and DHA. For immune and anti-inflammatory outcomes, doses of 2–3 g per day are common, typically studied over periods of 8 to 16 weeks.

What are the potential side effects of omega-3 supplementation?

Common side effects include fishy aftertaste, burping, and mild gastrointestinal effects. High doses (above 3 g per day) may increase bleeding risk and should be discussed with a healthcare provider, especially before surgery or if taking anticoagulants.

Omega-3 Fatty Acids (EPA/DHA)
Omega-3 Fatty Acids (EPA/DHA)

fatty_acid

Aussi connu sous le nom de: Fish Oil, Eicosapentaenoic Acid, Docosahexaenoic Acid, Marine Omega-3

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About

EPA and DHA alter cell membrane phospholipid composition and give rise to specialized pro-resolving mediators (resolvins, protectins, maresins) that actively resolve inflammation. The VITAL trial showed a 15% reduction in autoimmune disease risk. DHA showed stronger anti-inflammatory effects than EPA in randomized studies.

How It Works

EPA and DHA alter cell membrane phospholipid composition and give rise to specialized pro-resolving mediators (resolvins, protectins, maresins); EPA inhibits NF-kB activation; DHA suppresses pro-inflammatory gene expression.

Evidence For Conditions

Pathologie	Note	Études	Participants
Chronic Inflammation	A	30	30000	Voir →
Autoimmune Conditions	B	10	25000	Voir →

Side Effects

Fishy aftertaste and burping
Gastrointestinal discomfort (nausea, diarrhea)
Increased bleeding risk at high doses
Potential LDL cholesterol increase at very high doses

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk)
Blood pressure medications (additive blood pressure lowering)
Orlistat (may reduce omega-3 absorption)
Cyclosporine (may modify immunosuppressive effects)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Conjugated Linoleic Acid

En bref

Posologie: General: 250-500 mg combined EPA/DHA/day; Anti_Inflammatory: 1,000-3,000 mg combined EPA/DHA/day
Formes: softgel liquid capsule
Sources naturelles: Salmon, Mackerel, Sardines, Anchovies, Walnuts, Flaxseed
Limite supérieure: 3,000 mg/day EPA+DHA (FDA-recognized as safe)
Meilleur moment: With meals

Synthèse des preuves

Chronic Inflammation A

Autoimmune Conditions B

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.