What is the recommended dosage for Maitake Mushroom?

General: 1-3 g/day; Md Fraction: 35-70 mg/day MD-Fraction extract

What are the side effects of Maitake Mushroom?

Potential side effects include: Generally well tolerated, Mild gastrointestinal effects at high doses, Potential hypoglycemia.

What is maitake and how does it support immune health?

Maitake (Grifola frondosa) is an edible mushroom containing D-fraction beta-glucans that have been studied for their potential to activate macrophages, dendritic cells, and natural killer cells. It is one of the more researched medicinal mushrooms for immune support.

What dosage of maitake has been used in clinical trials?

Studies have used maitake D-fraction extract at doses of 35–100 mg per day, or whole maitake powder at 3–7 g per day. Clinical data in humans remains limited compared to preclinical studies.

What are the potential side effects of maitake?

Maitake is generally well tolerated as a food and supplement. Mild gastrointestinal effects may occur. It may lower blood sugar and blood pressure, so individuals on diabetes or blood pressure medications should consult a healthcare provider.

Maitake Mushroom

mushroom

Also known as: Grifola frondosa, Hen of the Woods, D-Fraction, MD-Fraction

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About

Maitake (Grifola frondosa) contains MD-Fraction (beta-1,6/1,3-glucan) that activates macrophages, dendritic cells, and NK cells via Dectin-1 and complement receptor 3. It enhances Th1 cytokine response while modulating Th2 response. Licensed as a cancer adjunctive treatment in Japan.

How It Works

MD-Fraction (beta-1,6/1,3-glucan) activates macrophages, dendritic cells, and NK cells via Dectin-1 and complement receptor 3; enhances Th1 cytokine response (IL-12, IFN-gamma) while modulating Th2 response.

Evidence For Conditions

Condition	Grade	Studies	Participants
Immune Aging (Immunosenescence)	C	3	100	View →

Side Effects

Generally well tolerated
Mild gastrointestinal effects at high doses
Potential hypoglycemia

Drug & Supplement Interactions

Diabetes medications (may lower blood sugar)
Anticoagulants (may increase bleeding risk)
Immunosuppressant medications (may counteract immunosuppression)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Chaga Mushroom Cordyceps Reishi Mushroom Turkey Tail Mushroom

Quick Facts

Dosage: General: 1-3 g/day; Md_Fraction: 35-70 mg/day MD-Fraction extract
Forms: capsule powder liquid extract whole mushroom
Natural Sources: Wild or cultivated Grifola frondosa
Upper Limit: No established UL
Best Time: With or without food

Evidence Summary

Immune Aging (Immunosenescence) C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.