Vitamin D per Autoimmune Conditions
AThe VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'immunecited.com';
const params = 'ingredient\u003Dvitamin\u002Dd\u0026condition\u003Dautoimmune\u002Dconditions';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
A
In sintesi
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
vs: None
Outcome: rheumatoid arthritis disease activity modulation through diet
Effetto: None
None
Popolazione: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
vs: None
Outcome: RA risk and disease activity
Effetto: None
None
Popolazione: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
vs: None
Outcome: None
Effetto: None
None
Popolazione: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
vs: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
Effetto: None
None
Popolazione: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
vs: None
Outcome: Neuroprotection
Effetto: None
None
Popolazione: None
Key Statistics
3
Studi
25871
Partecipanti
↑
Positive
A
Grado
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 citazioni
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 citazioni
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 citazioni
Immunity & ageing …
2024
12 citazioni
Frontiers in immunology
2024
9 citazioni
Autoimmunity reviews
2024
6 citazioni
Biochemical pharmacology
2024
6 citazioni
Indian dermatology online …
2024
3 citazioni
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 citazioni
Biomolecules
2023
70 citazioni
Autoimmunity reviews
2023
65 citazioni
The American journal …
2023
37 citazioni
Frontiers in immunology
2023
33 citazioni
Nutrients
2023
24 citazioni
Seminars in arthritis …
2023
17 citazioni
Mini reviews in …
2023
9 citazioni
Journal of cosmetic …
2023
4 citazioni
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 citazioni
International journal of …
2022
102 citazioni
Endocrine connections
2022
50 citazioni
Nutrients
2022
29 citazioni
Pathophysiology : the …
2022
24 citazioni
Frontiers in bioscience …
2022
17 citazioni
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
2022
11 citazioni
BMJ (Clinical research …
2022
9 citazioni
Nederlands tijdschrift voor …
2022
1 citazioni
Medical sciences (Basel, …
2021
157 citazioni
International journal of …
2021
6 citazioni
JAAD international
2021
5 citazioni
Nutrients
2020
229 citazioni
Calcified tissue international
2020
185 citazioni
Nutrients
2020
41 citazioni
Acta biochimica Polonica
2020
10 citazioni
Advances in experimental …
2020
8 citazioni
Journal of autoimmunity
2019
604 citazioni
International journal of …
2019
109 citazioni
The genetics of vitamin D.
Review
Bone
2019
62 citazioni
Therapeutics and clinical …
2019
4 citazioni
Journal of research …
2018
48 citazioni
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 citazioni
Thyroid : official …
2017
170 citazioni
The Israel Medical …
2017
117 citazioni
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 citazioni
Clinical reviews in …
2017
46 citazioni
Postepy dermatologii i …
2017
31 citazioni
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 citazioni
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 citazioni
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 citazioni
Postepy dermatologii i …
2016
59 citazioni
Indian dermatology online …
2016
51 citazioni
Current gastroenterology reports
2016
22 citazioni
Nutrients
2015
210 citazioni
Frontiers in immunology
2015
102 citazioni
Journal of drugs …
2015
50 citazioni
The Proceedings of …
2015
46 citazioni
Clinica chimica acta; …
2015
43 citazioni
Healthcare (Basel, Switzerland)
2015
7 citazioni
Vitamin D and immunity.
Review
F1000prime reports
2014
79 citazioni
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 citazioni
Clinical reviews in …
2013
259 citazioni
British journal of …
2013
156 citazioni
Dermato-endocrinology
2013
62 citazioni
Clinics and research …
2013
56 citazioni
Multiple sclerosis.
Review
Global advances in …
2013
19 citazioni
Presse medicale (Paris, …
2013
4 citazioni
Journal of investigative …
2011
563 citazioni
Vitamins and hormones
2011
25 citazioni
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 citazioni
Acta medica Indonesiana
2007
4 citazioni
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 citazioni
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Limite massimo: 4,000 IU/day (100 mcg)
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
Momento migliore per l'assunzione: With a meal containing fat for better absorption
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Interazioni note
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Livello di assunzione massimo tollerabile: 4,000 IU/day (100 mcg)
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Autoimmune Conditions
Vitamin D per altre condizioni
Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.