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Quercetin 관련 Allergic Rhinitis

C

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

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C

결론

Research suggests quercetin may inhibit mast cell degranulation and histamine release, providing natural antihistamine-like effects. It also acts as a zinc ionophore, potentially enhancing intracellular zinc concentration. Clinical evidence is emerging but still limited.

Key Study Findings

Review
Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
Dose: None vs: None Outcome: None 효과: None None

대상 집단: None

Observational Study
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics …
Dose: None vs: None Outcome: HMOX1 causal relationship with airway diseases 효과: CRSwNP OR 0.945, AR OR 0.997, AS OR 0.935 p=0.044, p=0.007, p=0.003

대상 집단: CRSwNP, allergic rhinitis, asthma (MR analysis)

Meta-Analysis n=823
Clinical Effects of Polyphenolic Compounds on Allergic Rhinitis: A Systematic Review and Meta-Analysis.
Dose: None vs: Placebo or control Outcome: Total nasal symptom scores in allergic rhinitis 효과: SMD=0.75 0.0001

대상 집단: Patients with seasonal or perennial allergic rhinitis

In Vitro
In-silico exploring pathway and mechanism-based therapeutics for allergic rhinitis: Network pharmacology, molecular docking, ADMET, quantum …
Dose: None vs: None Outcome: Binding affinity to NFKB1, TRAF6, IL5, IL6 효과: Predicted IC50 <50 nM None

대상 집단: In silico/computational models

Other
Network pharmacology analysis of the Huangqi-Gancao herb pair reveals quercetin as a therapeutics for allergic …
Dose: None vs: OVA-induced AR mice without treatment Outcome: Allergic rhinitis symptoms and histopathology 효과: None None

대상 집단: OVA-induced allergic rhinitis mouse model

Key Statistics

5

연구

400

참여자

Positive

C

등급

Referenced Papers

Allergy, asthma, and … 2020 152 인용
Medicines (Basel, Switzerland) 2020 24 인용
Molecules (Basel, Switzerland) 2016 395 인용
Evidence-based complementary and … 2013 33 인용
Alternative medicine review … 2000

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

일반적으로 사용되는 용량

general:
500-1,000 mg/day
immunesupport:
500-1,500 mg/day

상한량: No established UL; GRAS up to 500 mg/day per FDA

연구에서 사용된 용량

용량 기간 효과 N
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Positive 823
None -- Positive --
None -- Positive --
None -- Positive --
Quertal + antihistamines 12 weeks Positive 100

권장 복용 시간: With meals (fat-containing meals improve absorption); often paired with vitamin C or bromelain for enhanced bioavailability

Safety & Side Effects

보고된 부작용

  • Headache
  • Tingling in extremities
  • Gastrointestinal discomfort
  • Low oral bioavailability (addressed by phytosome formulations)

알려진 상호작용

  • Cyclosporine (may increase drug levels)
  • Fluoroquinolone antibiotics (may interfere with bacterial target)
  • CYP3A4 and CYP2C8 substrates (may inhibit metabolism)

일일 최대 섭취 허용량: No established UL; GRAS up to 500 mg/day per FDA

건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.

Frequently Asked Questions

Does Quercetin help with Allergic Rhinitis?
Based on 5 studies with 400 participants, there is limited but promising evidence that Quercetin may support Allergic Rhinitis management. Our evidence grade is C (Some Evidence).
How much Quercetin should I take for Allergic Rhinitis?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Headache, Tingling in extremities, Gastrointestinal discomfort, Low oral bioavailability (addressed by phytosome formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and Allergic Rhinitis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

관련 다른 성분: Allergic Rhinitis

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.