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Vitamin D para Autoimmune Conditions

A

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.

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A

Conclusão

The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.

Key Study Findings

Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None vs: None Outcome: rheumatoid arthritis disease activity modulation through diet Efeito: None None

População: patients with rheumatoid arthritis

Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None vs: None Outcome: RA risk and disease activity Efeito: None None

População: Patients with rheumatoid arthritis

Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None vs: None Outcome: None Efeito: None None

População: None

Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None vs: None Outcome: None Efeito: None None

População: Systematic review of nutraceuticals in rheumatoid arthritis

Controlled Clinical Trial 26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily vs: No supplementation Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI) Efeito: None None

População: SLE patients (EULAR/ACR 2019 criteria)

Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None vs: None Outcome: Neuroprotection Efeito: None None

População: None

Key Statistics

3

Estudos

25871

Participantes

Positive

A

Nota

Referenced Papers

Nature reviews. Endocrinology 2025 14 citações
Autoimmunity reviews 2024 6 citações
Biomolecules 2023 70 citações
Mini reviews in … 2023 9 citações
Endocrine connections 2022 50 citações
Pathophysiology : the … 2022 24 citações
Frontiers in bioscience … 2022 17 citações
BMJ (Clinical research … 2022 9 citações
Nederlands tijdschrift voor … 2022 1 citações
Medical sciences (Basel, … 2021 157 citações
Calcified tissue international 2020 185 citações
Acta biochimica Polonica 2020 10 citações
Advances in experimental … 2020 8 citações
Journal of autoimmunity 2019 604 citações
International journal of … 2019 109 citações
Bone 2019 62 citações
Journal of research … 2018 48 citações
Wiadomosci lekarskie (Warsaw, … 2018 2 citações
Thyroid : official … 2017 170 citações
Analytical biochemistry 2017 47 citações
Clinical reviews in … 2017 46 citações
Postepy dermatologii i … 2017 31 citações
Scandinavian journal of … 2016 81 citações
Postepy dermatologii i … 2016 59 citações
Indian dermatology online … 2016 51 citações
Current gastroenterology reports 2016 22 citações
Frontiers in immunology 2015 102 citações
Clinica chimica acta; … 2015 43 citações
Healthcare (Basel, Switzerland) 2015 7 citações
F1000prime reports 2014 79 citações
Pediatric clinics of … 2014 25 citações
Clinical reviews in … 2013 259 citações
British journal of … 2013 156 citações
Clinics and research … 2013 56 citações
Global advances in … 2013 19 citações
Presse medicale (Paris, … 2013 4 citações
Journal of investigative … 2011 563 citações
Vitamins and hormones 2011 25 citações
Molecular oncology 2011
Acta medica Indonesiana 2007 4 citações
American family physician 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:
600-800 IU/day
immunesupport:
1,000-2,000 IU/day
deficiencycorrection:
4,000-5,000 IU/day (under medical supervision)

Limite superior: 4,000 IU/day (100 mcg)

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
None -- Positive --
None -- Positive --
None -- Mixed --
None -- Mixed --
4000 IU or 8000 IU daily 26 weeks Positive --
None -- Positive --
None -- Neutral --
None -- Neutral --

Melhor horário: With a meal containing fat for better absorption

Safety & Side Effects

Efeitos Colaterais Relatados

  • Hypercalcemia at very high doses (nausea, vomiting, weakness)
  • Kidney stones with excessive long-term use
  • Constipation
  • Metallic taste

Interações Conhecidas

  • Thiazide diuretics (may increase risk of hypercalcemia)
  • Corticosteroids (reduce vitamin D absorption and metabolism)
  • Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
  • Statins (vitamin D may affect statin metabolism)

Ingestão máxima tolerável: 4,000 IU/day (100 mcg)

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Autoimmune Conditions

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.