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ImmuneCited

Conjugated Linoleic Acid для Chronic Inflammation

D

Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.

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D

Итог

Animal studies show CLA may have immunomodulatory effects via PPAR-gamma activation. Human evidence for immune-specific outcomes is limited and inconsistent, with some studies showing no significant benefit.

Key Study Findings

Review
A perspective on the chemical structures and molecular mechanisms of curcumin and its derivatives and …
Dose: None или: None Outcome: None Эффект: None None

Популяция: Review of curcumin derivatives in cancer treatment

Review
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Dose: None или: None Outcome: None Эффект: None None

Популяция: review of dietary polyphenols in type 2 diabetes mellitus management

Review
Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects …
Dose: None или: None Outcome: Musculoskeletal aging and cellular senescence Эффект: None None

Популяция: Aging adults with musculoskeletal decline (review)

Review
Retracted: Chronic Epipharyngitis Treated with Epipharyngeal Abrasion Therapy: Symptoms, Diagnosis, Pathogenesis, and Treatment Outcomes.
Dose: 1% zinc chloride solution или: None Outcome: Chronic epipharyngitis symptom improvement Эффект: None None

Популяция: Patients with chronic epipharyngitis (retracted publication)

Systematic Review
Research progress on traditional Chinese medicine compounds in autoimmune-related skin diseases.
Dose: None или: None Outcome: None Эффект: None None

Популяция: Review of TCM compounds in autoimmune skin diseases

Other
The omega effect: Harnessing fish oil for health.
Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Key Statistics

3

Исследования

150

Участники

Mixed

D

Оценка

Referenced Papers

Frontiers in immunology 2025 1 цитирований
Newborn (Clarksville, Md.) 2024 9 цитирований
International immunopharmacology 2023 8 цитирований
Biomolecular concepts 2022 18 цитирований
Frontiers in medicine 2021 6 цитирований
Prostaglandins, leukotrienes, and … 2018 38 цитирований
Medicines (Basel, Switzerland) 2018 23 цитирований
Current pharmaceutical design 2017 168 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
1.5-3 g/day

Верхний предел: No established UL

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Mixed --
None -- Positive --
None -- Positive --
1% zinc chloride solution -- Positive --
None -- Mixed --
None -- Mixed --
200 mg 5 weeks Positive --
None -- Positive --

Лучшее время приёма: With meals

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Gastrointestinal discomfort (nausea, diarrhea)
  • Fatigue
  • May worsen insulin sensitivity in some individuals
  • Liver fat accumulation (some formulations)

Известные взаимодействия

  • Diabetes medications (may affect insulin sensitivity)
  • Anticoagulants (may have additive effects)

Допустимый верхний уровень потребления: No established UL

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Conjugated Linoleic Acid help with Chronic Inflammation?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that Conjugated Linoleic Acid may support Chronic Inflammation management. Our evidence grade is D (Very Early Research).
How much Conjugated Linoleic Acid should I take for Chronic Inflammation?
Studies have used various dosages. A commonly studied range is 1.5-3 g/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Conjugated Linoleic Acid?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Fatigue, May worsen insulin sensitivity in some individuals, Liver fat accumulation (some formulations). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Conjugated Linoleic Acid and Chronic Inflammation?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

Related Evidence

Другие ингредиенты для Chronic Inflammation

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.