Vitamin D для Autoimmune Conditions
AThe VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
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A
Итог
The VITAL trial (25,871 participants over 5 years) demonstrated vitamin D supplementation at 2,000 IU/day may reduce autoimmune disease risk by 22%. This represents one of the largest and longest randomized trials of vitamin D for autoimmune disease prevention.
Key Study Findings
Review
Impact of Nutritional Diet Therapy on Rheumatoid Arthritis Disease Activity.
Dose: None
или: None
Outcome: rheumatoid arthritis disease activity modulation through diet
Эффект: None
None
Популяция: patients with rheumatoid arthritis
Review
The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive …
Dose: None
или: None
Outcome: RA risk and disease activity
Эффект: None
None
Популяция: Patients with rheumatoid arthritis
Review
Hypoparathyroidism: diagnosis, management and emerging therapies.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: None
Systematic Review
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: Systematic review of nutraceuticals in rheumatoid arthritis
Controlled Clinical Trial
26 weeks
Effects of Vitamin D Supplementation on Fatigue and Disease Activity in Systemic Lupus Erythematosus.
Dose: 4000 IU or 8000 IU daily
или: No supplementation
Outcome: Fatigue (FACIT-Fatigue, FSS) and disease activity (SELENA-SLEDAI)
Эффект: None
None
Популяция: SLE patients (EULAR/ACR 2019 criteria)
Review
Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.
Dose: None
или: None
Outcome: Neuroprotection
Эффект: None
None
Популяция: None
Key Statistics
3
Исследования
25871
Участники
↑
Positive
A
Оценка
Referenced Papers
Nutrients
2026
Nature reviews. Endocrinology
2025
14 цитирований
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions.
Systematic Review
Inflammopharmacology
2025
1 цитирований
Nutrients
2025
Cureus
2025
Arthritis & rheumatology …
2024
25 цитирований
Immunity & ageing …
2024
12 цитирований
Frontiers in immunology
2024
9 цитирований
Autoimmunity reviews
2024
6 цитирований
Biochemical pharmacology
2024
6 цитирований
Indian dermatology online …
2024
3 цитирований
The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patient-Driven, Multistep-Approach Study.
Systematic Review
Nutrients
2024
2 цитирований
Biomolecules
2023
70 цитирований
Autoimmunity reviews
2023
65 цитирований
The American journal …
2023
37 цитирований
Frontiers in immunology
2023
33 цитирований
Nutrients
2023
24 цитирований
Seminars in arthritis …
2023
17 цитирований
Mini reviews in …
2023
9 цитирований
Journal of cosmetic …
2023
4 цитирований
Journal of Nepal …
2023
BMJ (Clinical research …
2022
307 цитирований
International journal of …
2022
102 цитирований
Endocrine connections
2022
50 цитирований
Nutrients
2022
29 цитирований
Pathophysiology : the …
2022
24 цитирований
Frontiers in bioscience …
2022
17 цитирований
Evaluation of several immune and inflammatory indicators and their association with alopecia areata.
Other
Journal of cosmetic …
2022
11 цитирований
BMJ (Clinical research …
2022
9 цитирований
Nederlands tijdschrift voor …
2022
1 цитирований
Medical sciences (Basel, …
2021
157 цитирований
International journal of …
2021
6 цитирований
JAAD international
2021
5 цитирований
Nutrients
2020
229 цитирований
Calcified tissue international
2020
185 цитирований
Nutrients
2020
41 цитирований
Acta biochimica Polonica
2020
10 цитирований
Advances in experimental …
2020
8 цитирований
Journal of autoimmunity
2019
604 цитирований
International journal of …
2019
109 цитирований
The genetics of vitamin D.
Review
Bone
2019
62 цитирований
Therapeutics and clinical …
2019
4 цитирований
Journal of research …
2018
48 цитирований
[Early reumatoid arthritis].
Review
Wiadomosci lekarskie (Warsaw, …
2018
2 цитирований
Thyroid : official …
2017
170 цитирований
The Israel Medical …
2017
117 цитирований
Cholesterolomics: An update.
Review
Analytical biochemistry
2017
47 цитирований
Clinical reviews in …
2017
46 цитирований
Postepy dermatologii i …
2017
31 цитирований
Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands.
Review
Current medicinal chemistry
2017
14 цитирований
Serum Vitamin D Level and Rheumatoid Arthritis Disease Activity: Review and Meta-Analysis.
Meta-Analysis
PloS one
2016
152 цитирований
Vitamin D and autoimmunity.
Review
Scandinavian journal of …
2016
81 цитирований
Postepy dermatologii i …
2016
59 цитирований
Indian dermatology online …
2016
51 цитирований
Current gastroenterology reports
2016
22 цитирований
Nutrients
2015
210 цитирований
Frontiers in immunology
2015
102 цитирований
Journal of drugs …
2015
50 цитирований
The Proceedings of …
2015
46 цитирований
Clinica chimica acta; …
2015
43 цитирований
Healthcare (Basel, Switzerland)
2015
7 цитирований
Vitamin D and immunity.
Review
F1000prime reports
2014
79 цитирований
Pediatric vitiligo.
Review
Pediatric clinics of …
2014
25 цитирований
Clinical reviews in …
2013
259 цитирований
British journal of …
2013
156 цитирований
Dermato-endocrinology
2013
62 цитирований
Clinics and research …
2013
56 цитирований
Multiple sclerosis.
Review
Global advances in …
2013
19 цитирований
Presse medicale (Paris, …
2013
4 цитирований
Journal of investigative …
2011
563 цитирований
Vitamins and hormones
2011
25 цитирований
Melanoma and vitamin D.
Review
Molecular oncology
2011
Nature clinical practice. …
2009
154 цитирований
Acta medica Indonesiana
2007
4 цитирований
Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.
Review
Journal of the …
2006
45 цитирований
Chronic plaque psoriasis.
Review
American family physician
2006
Proceedings of the …
2000
281 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 600-800 IU/day
- immunesupport:
- 1,000-2,000 IU/day
- deficiencycorrection:
- 4,000-5,000 IU/day (under medical supervision)
Верхний предел: 4,000 IU/day (100 mcg)
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4000 IU or 8000 IU daily | 26 weeks | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Neutral | -- |
Лучшее время приёма: With a meal containing fat for better absorption
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Hypercalcemia at very high doses (nausea, vomiting, weakness)
- ⚠ Kidney stones with excessive long-term use
- ⚠ Constipation
- ⚠ Metallic taste
Известные взаимодействия
- ● Thiazide diuretics (may increase risk of hypercalcemia)
- ● Corticosteroids (reduce vitamin D absorption and metabolism)
- ● Orlistat and cholestyramine (reduce fat-soluble vitamin absorption)
- ● Statins (vitamin D may affect statin metabolism)
Допустимый верхний уровень потребления: 4,000 IU/day (100 mcg)
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Vitamin D help with Autoimmune Conditions?
Based on 3 studies with 25,871 participants, there is strong evidence from multiple clinical trials that Vitamin D may support Autoimmune Conditions management. Our evidence grade is A (Strong Evidence).
How much Vitamin D should I take for Autoimmune Conditions?
Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin D?
Reported side effects may include Hypercalcemia at very high doses (nausea, vomiting, weakness), Kidney stones with excessive long-term use, Constipation, Metallic taste. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin D and Autoimmune Conditions?
We rate the evidence as Grade A (Strong Evidence). This rating is based on 3 peer-reviewed studies with 25,871 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Autoimmune Conditions
Vitamin D для других состояний
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