Zinc için Upper Respiratory Tract Infections

Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day showed 40% duration reduction. Doses below 75 mg/day showed no effect.

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Key Study Findings

Observational Study n=107 Open-label

Additive effect of free-choice olfactory training combined with pharmacotherapy: A retrospective analysis of post-viral olfactory …

Dose: tokishakuyakusan, zinc sulfate, methylcobalamin vs: medication alone Outcome: olfactory function improvement via T&T olfactometry Etki: OR=4.96 p=0.009

Popülasyon: patients with post-viral olfactory dysfunction (non-COVID)

Review

Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a …

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: None

Review

UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses …

Dose: None vs: None Outcome: None Etki: None None

Popülasyon: Elite/professional cyclists nutrition review

Meta-Analysis

Effect of Oral Nutritional Supplementation on Health-Related Outcomes and Nutritional Biomarkers in Children and Adolescents …

Dose: Various oral nutritional supplements vs: Standard diet or placebo Outcome: Health outcomes and nutritional biomarkers Etki: None None

Popülasyon: Children/adolescents with undernutrition

Controlled Clinical Trial n=120 5 weeks Single-blind

Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, …

Dose: 20 or 30 days treatment vs: Standard treatment only (nasal aerosol) Outcome: Otoscopy, impedance, fibroscopy, pure auditory test Etki: None None

Popülasyon: Children with otitis media

Review

Associations of fine particulate matter and constituents with pediatric emergency room visits for respiratory diseases …

Dose: 31 μg vs: None Outcome: None Etki: None None

Popülasyon: respiratory disease

Key Statistics

Çalışmalar

1500

Katılımcılar

↑

Positive

Derece

Referenced Papers

Additive effect of free-choice olfactory training combined with pharmacotherapy: A retrospective analysis of post-viral olfactory dysfunction. Other

Auris, nasus, larynx 2026

UCI Sports Nutrition Project: The Role of Nutrition in the Prevention and Management of Illnesses and Injuries in Elite Cycling. Other

International journal of … 2025 2 atıf

Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a narrative review. Review

Nutrition research reviews 2025

Effect of Oral Nutritional Supplementation on Health-Related Outcomes and Nutritional Biomarkers in Children and Adolescents with Undernutrition: A Systematic Review … Meta-Analysis

Nutrients 2024 2 atıf

Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, Magnesium, Honey, Tyndallized Lactobacillus Acidophilus … Other

Healthcare (Basel, Switzerland) 2022 7 atıf

Diversity and genomic determinants of the microbiomes associated with COVID-19 and non-COVID respiratory diseases. Other

Gene reports 2021 33 atıf

Associations of fine particulate matter and constituents with pediatric emergency room visits for respiratory diseases in Shanghai, China. Review

International journal of … 2021 26 atıf

Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer. Review

Archivio italiano di … 2019 117 atıf

Infection Status of Rural Schoolchildren and its Relationship with Vitamin D Concentrations. RCT

Indian journal of … 2019 3 atıf

Management of minor ailments in a community pharmacy setting: Findings from simulated visits and qualitative study in Gondar town, Ethiopia. Other

PloS one 2018 48 atıf

Non-prescribed sale of antibiotics for acute childhood diarrhea and upper respiratory tract infection in community pharmacies: a 2 phase mixed-methods … Other

Antimicrobial resistance and … 2018 46 atıf

Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies. Review

Journal of evidence-based … 2017 134 atıf

Intake of vitamin C, vitamin E, selenium, zinc and polyunsaturated fatty acids and upper respiratory tract infection-a prospective cohort study. Other

European journal of … 2017 18 atıf

Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: A 12-month randomised … RCT

Allergologia et immunopathologia 2016 31 atıf

Association between serum vitamin D, retinol and zinc status, and acute respiratory infections in underweight and normal-weight children aged 6-24 … Other

Epidemiology and infection 2016 13 atıf

Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials. Other

mBio 2015 414 atıf

Pharmacy-based dispensing of antimicrobial agents without prescription in India: appropriateness and cost burden in the private sector. Other

Antimicrobial resistance and … 2015 113 atıf

Discovery of human zinc deficiency: its impact on human health and disease. Review

Advances in nutrition … 2013 807 atıf

Serum Zinc Level in Children Presenting with Febrile Seizures. Other

Pakistan journal of … 2013 33 atıf

Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia. RCT

The British journal … 2012 40 atıf

New actions for old nutrients. Review

Acta scientiarum polonorum. … 2012 11 atıf

Zinc and vitamin A for prevention of upper respiratory tract infection in children. Other

The British journal … 2012 2 atıf

Treatment of the common cold in children and adults. Review

American family physician 2012

Vitamin D and tonsil disease--preliminary observations. Other

International journal of … 2011 49 atıf

Ingestion of micronutrient fortified breakfast cereal has no influence on immune function in healthy children: a randomized controlled trial. RCT

Nutrition journal 2011 12 atıf

Zinc supplementation and TNF-α levels in vaccinated cardiac patients. RCT

Journal of trace … 2011 11 atıf

Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and … Review

Arthritis research & … 2010 17 atıf

[Clinical analysis of hyposmia-associated taste dysfunction]. Other

Nihon Jibiinkoka Gakkai … 2009 1 atıf

Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Review

Alternative medicine review … 2007 163 atıf

WITHDRAWN: Zinc for the common cold. Systematic Review

The Cochrane database … 2007 24 atıf

Complementary and alternative medicine for upper-respiratory-tract infection in children. Review

American journal of … 2006 51 atıf

Nutritional formula enhanced immune function and reduced days of symptoms of upper respiratory tract infection in seniors. RCT

Journal of the … 2004 74 atıf

Upper respiratory tract infection. Review

Clinical evidence 2003

Upper respiratory tract infection. Review

Clinical evidence 2003

Respiratory and allergic diseases: from upper respiratory tract infections to asthma. Review

Primary care 2002 56 atıf

Upper respiratory tract infection. Other

American family physician 2002

Exercise immunology: nutritional countermeasures. Review

Canadian journal of … 2001 72 atıf

Sudden infant death syndrome Part 2: the response of the reticuloendothelial system to hypoxemia and infection. Other

Medical hypotheses 2001 8 atıf

Zinc for the common cold. Systematic Review

The Cochrane database … 2000 294 atıf

Hypozincaemia in febrile convulsion. Other

European journal of … 1996 54 atıf

[Acrodermatitis enteropathica; a literature review]. Review

Nederlands tijdschrift voor … 1991

Subacute zinc deficiency in children with recurrent upper respiratory tract infection. Other

European journal of … 1987 14 atıf

Zinc in hair and urine of paediatric patients. Other

Clinica chimica acta; … 1986 15 atıf

Disorders of taste and smell. Review

Southern medical journal 1978 3 atıf

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

general:: 8-11 mg/day
coldtreatment:: 75-100 mg/day elemental zinc (lozenges, within 24h of onset, up to 2 weeks)
immunesupport:: 15-30 mg/day

Üst sınır: 40 mg/day (long-term)

Araştırmalarda İncelenen Dozajlar

Dozaj	Süre	Etki	N
tokishakuyakusan, zinc sulfate, methylcobalamin	--	Positive	107
None	--	Mixed	--
None	--	Mixed	--
Various oral nutritional supplements	--	Positive	--
20 or 30 days treatment	5 weeks	Positive	120
31 μg	--	Neutral	--
94.57%	--	Mixed	--
None	--	Mixed	387

En iyi alım zamanı: Lozenges: dissolve slowly in mouth every 2-3h at cold onset; Supplements: with food to minimize nausea

Safety & Side Effects

Bildirilen Yan Etkiler

⚠ Nausea and vomiting (especially on an empty stomach)
⚠ Metallic taste in the mouth
⚠ Copper depletion with chronic high-dose use (>40 mg/day)
⚠ Headache and diarrhea

Bilinen Etkileşimler

● Copper supplements (zinc inhibits copper absorption at doses >40 mg/day)
● Tetracycline and quinolone antibiotics (mutual absorption reduction)
● Penicillamine (zinc reduces absorption of this rheumatoid arthritis drug)
● Iron supplements (mutual absorption interference when taken together)

Tolere edilebilir üst alım: 40 mg/day (long-term)

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does Zinc help with Upper Respiratory Tract Infections?

Based on 15 studies with 1,500 participants, there is strong evidence from multiple clinical trials that Zinc may support Upper Respiratory Tract Infections management. Our evidence grade is A (Strong Evidence).

How much Zinc should I take for Upper Respiratory Tract Infections?

Studies have used various dosages. A commonly studied range is 8-11 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Zinc?

Reported side effects may include Nausea and vomiting (especially on an empty stomach), Metallic taste in the mouth, Copper depletion with chronic high-dose use (>40 mg/day), Headache and diarrhea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Zinc and Upper Respiratory Tract Infections?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 15 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

Şu durum için diğer içerikler: Upper Respiratory Tract Infections

Vitamin D A Beta-Glucan A Vitamin C B Echinacea B Andrographis B Garlic B

Hızlı Değerlendirme

Meta-analysis of 7 trials demonstrates zinc lozenges at 75+ mg/day may reduce cold duration by 33% when started within 24 hours of symptom onset. Zinc acetate lozenges at 80-92 mg/day …

Evidence Strength92%

High confidence

Çalışma Dağılımı

RCT (6)Meta (1)Other (8)

Alternatifleri Karşılaştır

Bu durum için diğer bileşenlerin nasıl karşılaştırıldığını görün.Diğer içeriklerin bu sağlık durumu için nasıl karşılaştırıldığını görün.

Şu durum için tüm içerikleri görüntüle: Upper Respiratory Tract Infections

Daha Fazla Bilgi

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